Mechanisms of trauma-induced coagulopathy

Current Opinion in Hematology

Volumn 21, Issue 5, 2014, Pages 404-409

  Cardenas, Jessica C ^a   Wade, Charles E ^a   Holcomb, John B ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

coagulopathy; hemorrhage; injury; trauma

Indexed keywords

ACTIVATED PROTEIN C; FIBRINOGEN; PROTEIN C;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; ENDOTHELIAL DYSFUNCTION; FIBRINOLYSIS; HEMORRHAGIC SHOCK; HUMAN; HYPERFIBRINOLYSIS; INJURY; NONHUMAN; OXIDATION; OXIDATIVE MODIFICATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN MODIFICATION; THROMBOCYTE DYSFUNCTION; TRAUMA INDUCED COAGULOPATHY; ANIMAL; BLEEDING; BLOOD COAGULATION DISORDERS; COMPLICATION; ENDOTHELIUM CELL; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; THROMBOCYTE;

ANIMALS; BLOOD COAGULATION DISORDERS; BLOOD PLATELETS; ENDOTHELIAL CELLS; HEMORRHAGE; HUMANS; OXIDATION-REDUCTION; PROTEIN C;

EID: 84906090774     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000063     Document Type: Article

References (50)

1. Norton R, Kobusingye O. Injuries. N Engl J Med 2013; 368:1723-1730
2. D'Angelo MR, Dutton RP. Management of trauma-induced coagulopathy: Trends and practices. AANA J 2010; 78:35-40
3. Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 2008; 64:1211-1217
4. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: Mechanism, identification and effect. Curr Opin Crit Care 2007; 13:680-685
5. Maegele M, Schochl H, Cohen MJ. An update on the coagulopathy of trauma. Shock 2014; 41 (Suppl 1):21-25
6. McNamara JJ, Burran EL, Stremple JF, Molot MD. Coagulopathy after major combat injury: Occurrence, management, and pathophysiology. Ann Surg 1972; 176:243-246
7. Holcomb JB, Minei KM, Scerbo ML, et al. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: Experience with 1974 consecutive trauma patients. Ann Surg 2012; 256:476-486
8. Johansson PI, Sorensen AM, Larsen CF, et al. Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets. Transfusion 2013; 53:3088-3099
9. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: A review of mechanisms. J Trauma 2008; 65:748-754
10. Cotton BA, McCarthy JJ, Holcomb JB. Acutely injured patients on dabigatran. N Engl J Med 2011; 365:2039-2040
11. Brown LM, Call MS, Margaret Knudson M, et al. A normal platelet count may not be enough: The impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma 2011; 71 (Suppl 3): S337-S342
12. Solomon C, Traintinger S, Ziegler B, et al. Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost 2011; 106:322-330
13. Wohlauer MV, Moore EE, Thomas S, et al. Early platelet dysfunction: An unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg 2012; 214:739-746
14. Kutcher ME, Redick BJ, McCreery RC, et al. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg 2012; 73:13-19
15. Sillesen M, Johansson PI, Rasmussen LS, et al. Platelet activation and dysfunction in a large-Animal model of traumatic brain injury and hemorrhage. J Trauma Acute Care Surg 2013; 74:1252-1259
16. Ortmann E, Klein AA, Sharples LD, et al. Point-of-care assessment of hypothermia and protamine-induced platelet dysfunction with multiple electrode aggregometry (Multiplate(R)) in patients undergoing cardiopulmonary bypass. Anesth Analg 2013; 116:533-540
17. Wolberg AS, Meng ZH, Monroe DM 3rd, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma 2004; 56:1221-1228
18. Mohr J, Ruchholtz S, Hildebrand F, et al. Induced hypothermia does not impair coagulation system in a swine multiple trauma model. J Trauma Acute Care Surg 2013; 74:1014-1020
19. Windelov NA, Sorensen AM, Perner A, et al. Platelet aggregation following trauma: A prospective study. Blood Coagul Fibrinolysis 2014; 25: 67-73
20. Ohto H, Nollet KE. Overview on platelet preservation: Better controls over storage lesion. Transfus Apher Sci 2011; 44:321-325
21. Wenzel F, Hohlfeld T, Giers G. Soluble CD40L release as test for functional platelet loss. Clin Lab 2012; 58:337-342
22. Reddoch KM, Pidcoke HF, Montgomery RK, et al. Hemostatic function of apheresis platelets stored at 48C and 228C. Shock 2014; 41 (Suppl 1):54-61
23. Sillesen M, Rasmussen LS, Jin G, et al. Assessment of coagulopathy, endothelial injury, and inflammation after traumatic brain injury and hemorrhage in a porcine model. J Trauma Acute Care Surg 2014; 76:12-19
24. Rahbar E, Baer LA, Cotton BA, et al. Plasma colloid osmotic pressure is an early indicator of injury and hemorrhagic shock. Shock 2014; 41:181-187
25. Brown LM, Aro SO, Cohen MJ, et al. A high fresh frozen plasma: Packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio. J Trauma 2011; 71 (Suppl 3):S358-S363
26. Sadler JE, Lentz SR, Sheehan JP, et al. Structure-function relationships of the thrombin-thrombomodulin interaction. Haemostasis 1993; 23 (Suppl 1): 183-193
27. Shworak NW, Kobayashi T, De Agostini A, Smits NC. Anticoagulant heparan sulfate to not clot: Or not?. Prog Mol Biol Transl Sci 2010; 93:153-178
28. Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg 2012; 73:60-66
29. Torres LN, Sondeen JL, Ji L, et al. Evaluation of resuscitation fluids on endothelial glycocalyx, venular blood flow, and coagulation function after hemorrhagic shock in rats. J Trauma Acute Care Surg 2013; 75:759-766
30. Pati S, Matijevic N, Doursout MF, et al. Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. J Trauma 2010; 69 (Suppl 1):S55-S63
31. Sillesen M, Johansson PI, Rasmussen LS, et al. Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma. J Trauma Acute Care Surg 2014; 76:998-1007
32. Cohen MJ, Call M, Nelson M, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 2012; 255:379-385
33. Chesebro BB, Rahn P, Carles M, et al. Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock 2009; 32:659-665
34. Jansen JO, Scarpelini S, Pinto R, et al. Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity. J Trauma 2011; 71 (Suppl 1):S435-S440
35. Burney PR, White N, Pfaendtner J. Structural effects of methionine oxidation on isolated subdomains of human fibrin D and alphaC regions. PLoS One 2014; 9:e86981
36. Krotz F, SohnHY, Pohl U. Reactive oxygen species: Players in the platelet game. Arteriosclerosis, thrombosis, and vascular biology 2004; 24:1988-1996
37. Closa D, Folch-Puy E. Oxygen free radicals and the systemic inflammatory response. IUBMB Life 2004; 56:185-191
38. Askari AT, Brennan ML, Zhou X, et al. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med 2003; 197:615-624
39. Strandberg L, Lawrence DA, Johansson LB, Ny T. The oxidative inactivation of plasminogen activator inhibitor type 1 results from a conformational change in the molecule and does not require the involvement of the P1' methionine. J Biol Chem 1991; 266:13852-13858
40. Wood MJ, Helena Prieto J, Komives EA. Structural and functional consequences of methionine oxidation in thrombomodulin. Biochim Biophys Acta 2005; 1703:141-147
41. Nalian A, Iakhiaev AV. Possible mechanisms contributing to oxidative inactivation of activated protein C: Molecular dynamics study. Thromb Haemost 2008; 100:18-25
42. Cotton BA, Harvin JA, Kostousouv V, et al. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg 2012; 73:365-370
43. Chapman MP, Moore EE, Ramos CR, et al. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg 2013; 75:961-967
44. Raza I, Davenport R, Rourke C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 2013; 11:307-314
45. Cesarman-Maus G, Hajjar KA. Molecular mechanisms of fibrinolysis. Br J Haematol 2005; 129:307-321
46. Irigoyen JP, Munoz-Canoves P, Montero L, et al. The plasminogen activator system: Biology and regulation. Cell Mol Life Sci 1999; 56:104-132
47. Rijken DC, Lijnen HR. New insights into the molecular mechanisms of the fibrinolytic system. J Thromb Haemost 2009; 7:4-13
48. Cardenas JC, Matijevic N, Baer LA, et al. Elevated tissue plasminogen activator and reduced plasminogen activator inhibitor promote hyperfibrinolysis in trauma patients. Shock 2014; 41:514-521
49. Dirkmann D, Radu-Berlemann J, Gorlinger K, Peters J. Recombinant tissuetype plasminogen activator-evoked hyperfibrinolysis is enhanced by acidosis and inhibited by hypothermia but still can be blocked by tranexamic acid. J Trauma Acute Care Surg 2013; 74:482-488
50. Lustenberger T, Relja B, Puttkammer B, et al. Activated thrombin-Activatable fibrinolysis inhibitor (TAFIa) levels are decreased in patients with traumainduced coagulopathy. Thromb Res 2013; 131:e26-30.