Management of trauma-induced coagulopathy: Trends and practices

AANA Journal

Volumn 78, Issue 1, 2010, Pages 35-40

  D'Angelo, Matthew R ^a   Dutton, Richard P ^b  

^a UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

^b R ADAMS COWLEY SHOCK TRAUMA CENTER   (United States)

Author keywords

Coagulopathy; Trauma

Indexed keywords

ANTICOAGULANT PROTEIN; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; FIBRIN; FIBRINOGEN; FRESH FROZEN PLASMA; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN;

ACIDOSIS; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD VESSEL INJURY; CRYOPRECIPITATE; DRUG EFFECT; DRUG MECHANISM; FIBRINOLYSIS; FLUID RESUSCITATION; HEMORRHAGIC SHOCK; HUMAN; HYPOTHERMIA; INJURY; PERFUSION; REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTE TRANSFUSION; THROMBOEMBOLISM; TRAUMA INDUCED COAGULOPATHY; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ACIDOSIS; BLOOD COAGULATION DISORDERS; BRAIN INJURIES; FACTOR VIIA; FEVER; FLUID THERAPY; HUMANS; OFF-LABEL USE; RECOMBINANT PROTEINS; SHOCK, HEMORRHAGIC; WOUNDS AND INJURIES;

EID: 77949783052     PISSN: 00946354     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13 (6):680-685.
2. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. The Lancet. 2006;367(9524): 1747-1757.
3. Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64(5):1211-1217.
4. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38(2):185-193.
5. Stein DM, Dutton RP. Uses of recombinant factor VIIa in trauma. Curr Opin Crit Care. 2004;10(6):520-528.
6. Guyton AC, Hall JE. Textbook of Medical Physiology. 11th ed. Philadelphia, PA: WB Saunders; 2006.
7. Farkash U, Lynn M, Scope A, et al. Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties? Injury. 2002;33(2):103-110.
8. Shafi S, Elliott AC, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma. 2005;59(5):1081-1085.
9. Watts DD, Trask A, Soeken K, Perdue P, Dols S, Kaufmann C. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma. 1998;44(5):846-854.
10. Tsuei BJ, Kearney PA. Hypothermia in the trauma patient. Injury. 2004;35(1):7-15.
11. Dirkmann D, Hanke AA, Gorlinger K, Peters J. Hypothermia and acidosis synergistically impair coagulation in human whole blood. Anesth Analg. 2008;106(6):1627-1632.
12. Hessel EA 2nd, Schmer G, Dillard DH. Platelet kinetics during deep hypothermia. J Surg Res. 1980;28(1):23-34.
13. Kattlove HE, Gomez MH. Studies on the mechanism of ristocetin-induced platelet aggregation. Blood. 1975;45(1):91-96.
14. Hess JR. Blood and coagulation support in trauma care. Hematology/Am Soc Hematol Educ Program. 2007:187-191.
15. Advanced Trauma Life Support for Doctors: Student Course Manual. 7th ed. Chicago, IL: American College of Surgeons; 2004:32.
16. Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfusion Med Rev. 2003;17(3):223-231.
17. Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR. Blood transfusion rates in the care of acute trauma. Transfusion. 2004;44(6): 809-813.
18. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63(4):805-813.
19. Fresh-Frozen Plasma, Cryoprecipitate, and Platelets Administration Practice Guidelines Development Task Force of the College of American Pathologists. Practice parameter for the use of fresh-frozen plasma, cryoprecipitate, and platelets. JAMA. 1994;271(10):777-781.
20. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies. Anesthesiology. 2006;105:198-208. http://www.asahq.org/publicationsAndServices/BCTGuidesFinal.pdf. Accessed Dec 3, 2009.
21. Spahn DR, Cerny VC, Coats TJ, et al. Management of bleeding following major trauma: a European guideline. Crit Care. 2007;11(1):1-22.
22. Coronado VG, Johnson RL, Faul M, Kegler SR. Incidence rates of hospitalization related to traumatic brain injury - 12 states, 2002. MMWR. 2006;55(08):201-204. http://www.cdc.gov/mmwr/preview/mmwrhtml/ mm5508a2.htm Accessed June 7, 2002.
23. Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63(6):1254-1261.
24. Harhangi BS, Kompanje EJ, Leebeek FW, Maas AI. Coagulation disorders after traumatic brain injury. Acta Neurochir Wien. 2008;150(2):165-175.
25. Stein DM, Dutton RP. Kramer ME, Handley C, Scalea TM. Recombinant factor VIIa: decreasing time to intervention in coagulopathic patients with severe traumatic brain injury. J Trauma. 2008;64(3): 620-627.
26. Etemadrezaie H, Baharvahdat H, Shariati Z, Lari SM, Shaken MT, Ganjeifar B. The effect of fresh frozen plasma in severe closed head injury. Clin Neurol Neurosurg. 2007;109(2):166-171.
27. Klitgaard T, Tabanera y Palacios R, Boffard KD, et al, for NovoSeven Trauma Study Group. Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding. Crit Care. 2006;10(4):R104.
28. Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64(5):1211-1217.
29. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245(5):812-818.
30. Ganter MT, Brohi K, Cohen MJ, et al. Role of the alternative pathway in the early complement activation following major trauma. Shock. 2007;28(1):29-34.
31. Macias WL, Yan SB, Williams MD, et al. New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care. 2005;9(suppl 4):S38-S45.
32. Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331(17):1105-1109.
33. Shoemaker WC, Peitzman AB, Bellamy R, Bellomo R, Bruttig SP, Capone A, et al. Resuscitation from severe hemorrhage. Crit Care Med. 1996;24(2 suppl):S12-23.
34. Kenet G, Waiden R, Eldad A, Martinowitz U. Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1999;354(9193):1879.
35. Martinowitz U, Kenet G, Segal E, et al. Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma. 2001,51(3):431-438.
36. O'Neill PA, Bluth M, Gloster ES, et al. Successful use of recombinant activated factor VII for trauma-associated hemorrhage in a patient without preexisting coagulopathy. J Trauma. 2002;52(2):400-405.
37. Vlot AJ, Ton E, Mackaay AJ, Kramer MH, Gaillard CA. Treatment of a severely bleeding patient without preexisting coagulopathy with activated recombinant factor VII. Am J Med. 2001;108(5):421-423.
38. Dutton RP, Hess JR, Scalea TM. Recombinant factor VIIa for control of hemorrhage: early experience in critically ill trauma patients. J Clin Anesth. 2003;15(3):184-188.
39. Dutton RP. McCunn M, Hyder M, et al. Factor VIIa for correction of traumatic coagulopathy. J Trauma. 2004;57(4):709-719.
40. Boffard KD, Riou B, Warren B, et al, for NovoSeven Trauma Study Group. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma. 2005;59(1):8-15.
41. O'Connell KA, Wood JJ, Wise RP, et al. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006;295(3):293-298.
42. Stanworth SJ, Birchall J, Doree CJ, Hyde C. Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Systc Rev. 2007;(2):CD005011.
43. Thomas GO, Dutton RP, Hemlock B, et al. Thromboembolic complications associated with factor VIIa administration. J Trauma. 2007;62(3):564-569.