Possible mechanisms contributing to oxidative inactivation of activated protein C: Molecular dynamics study

Thrombosis and Haemostasis

Volumn 100, Issue 1, 2008, Pages 18-25

  Nalian, Armen ^b   Iakhiaev, Alexei V ^a  

^a SOUTH TEXAS COLLEGE OF LAW   (United States)

^b NONE

Author keywords

Gla domain proteins; Oxidative stress; Protein function activity

Indexed keywords

CARBOXYL GROUP; CHROMOGENIC SUBSTRATE; CYANOGEN BROMIDE; DROTRECOGIN; HISTIDINE; HYDROGEN PEROXIDE; HYPOCHLORITE; METHIONINE; NITROGEN; OXYGEN; SERINE;

ARTICLE; DRUG INHIBITION; MOLECULAR MODEL; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIMULATION;

ALLOSTERIC REGULATION; ASPARTIC ACID; BINDING SITES; COMPUTER SIMULATION; CYANOGEN BROMIDE; ENZYME ACTIVATION; ENZYME STABILITY; HISTIDINE; HUMANS; HYDROGEN BONDING; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; METHIONINE; MODELS, MOLECULAR; OXIDANTS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN C; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 46749093298     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-12-0750     Document Type: Article

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