-
1
-
-
79956077563
-
T cell exhaustion
-
Wherry EJ. T cell exhaustion. Nature Immunol 2011; 12:492-499.
-
(2011)
Nature Immunol
, vol.12
, pp. 492-499
-
-
Wherry, E.J.1
-
2
-
-
2442684151
-
Memory CD8 T-cell differentiation during viral infection
-
DOI 10.1128/JVI.78.11.5535-5545.2004
-
Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol 2004; 78:5535-5545. (Pubitemid 38661640)
-
(2004)
Journal of Virology
, vol.78
, Issue.11
, pp. 5535-5545
-
-
Wherry, E.J.1
Ahmed, R.2
-
3
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
DOI 10.1038/nature04444, PII NATURE04444
-
Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006; 439:682-687. (Pubitemid 43237609)
-
(2006)
Nature
, vol.439
, Issue.7077
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
Zhu, B.4
Allison, J.P.5
Sharpe, A.H.6
Freeman, G.J.7
Ahmed, R.8
-
4
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
DOI 10.1038/nature05115, PII NATURE05115
-
Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443:350-354. (Pubitemid 44435155)
-
(2006)
Nature
, vol.443
, Issue.7109
, pp. 350-354
-
-
Day, C.L.1
Kaufmann, D.E.2
Kiepiela, P.3
Brown, J.A.4
Moodley, E.S.5
Reddy, S.6
Mackey, E.W.7
Miller, J.D.8
Leslie, A.J.9
DePierres, C.10
Mncube, Z.11
Duraiswamy, J.12
Zhu, B.13
Eichbaum, Q.14
Altfeld, M.15
Wherry, E.J.16
Coovadia, H.M.17
Goulder, P.J.R.18
Klenerman, P.19
Ahmed, R.20
Freeman, G.J.21
Walker, B.D.22
more..
-
5
-
-
58149277359
-
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
-
Jones RB, Ndhlovu LC, Barbour JD, et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. Journal Exp Med 2008; 205:2763-2779.
-
(2008)
Journal Exp Med
, vol.205
, pp. 2763-2779
-
-
Jones, R.B.1
Ndhlovu, L.C.2
Barbour, J.D.3
-
6
-
-
34548680261
-
+ T cells correlates with disease progression and defines a reversible immune dysfunction
-
DOI 10.1038/ni1515, PII NI1515
-
Kaufmann DE, Kavanagh DG, Pereyra F, et al. Upregulation of CTLA-4 by HIVspecific CD4\+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007; 8:1246-1254. (Pubitemid 350011764)
-
(2007)
Nature Immunology
, vol.8
, Issue.11
, pp. 1246-1254
-
-
Kaufmann, D.E.1
Kavanagh, D.G.2
Pereyra, F.3
Zaunders, J.J.4
Mackey, E.W.5
Miura, T.6
Palmer, S.7
Brockman, M.8
Rathod, A.9
Piechocka-Trocha, A.10
Baker, B.11
Zhu, B.12
Le Gall, S.13
Waring, M.T.14
Ahern, R.15
Moss, K.16
Kelleher, A.D.17
Coffin, J.M.18
Freeman, G.J.19
Rosenberg, E.S.20
Walker, B.D.21
more..
-
7
-
-
33749338938
-
+ T cell survival in HIV infection
-
DOI 10.1084/jem.20061496
-
Petrovas C, Casazza JP, Brenchley JM, et al. PD-1 is a regulator of virus-specific CD8\+ T cell survival in HIV infection. J Exp Med 2006; 203:2281-2292. (Pubitemid 44498363)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.10
, pp. 2281-2292
-
-
Petrovas, C.1
Casazza, J.P.2
Brenchley, J.M.3
Price, D.A.4
Gostick, E.5
Adams, W.C.6
Precopio, M.L.7
Schacker, T.8
Roederer, M.9
Douek, D.C.10
Koup, R.A.11
-
8
-
-
34547931898
-
+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
-
DOI 10.1182/blood-2007-01-069112
-
Petrovas C, Price DA, Mattapallil J, et al. SIV-specific CD8\+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 2007; 110:928-936. (Pubitemid 47267431)
-
(2007)
Blood
, vol.110
, Issue.3
, pp. 928-936
-
-
Petrovas, C.1
Price, D.A.2
Mattapallil, J.3
Ambrozak, D.R.4
Geldmacher, C.5
Cecchinato, V.6
Vaccari, M.7
Tryniszewska, E.8
Gostick, E.9
Roederer, M.10
Douek, D.C.11
Morgan, S.H.12
Davis, S.J.13
Franchini, G.14
Koup, R.A.15
-
9
-
-
33749009709
-
+ T cells leads to reversible immune dysfunction
-
DOI 10.1038/nm1482, PII NM1482
-
Trautmann L, Janbazian L, Chomont N, et al. Upregulation of PD-1 expression on HIV-specific CD8\+ T cells leads to reversible immune dysfunction. Nat Med 2006; 12:1198-1202. (Pubitemid 44527357)
-
(2006)
Nature Medicine
, vol.12
, Issue.10
, pp. 1198-1202
-
-
Trautmann, L.1
Janbazian, L.2
Chomont, N.3
Said, E.A.4
Gimmig, S.5
Bessette, B.6
Boulassel, M.-R.7
Delwart, E.8
Sepulveda, H.9
Balderas, R.S.10
Routy, J.-P.11
Haddad, E.K.12
Sekaly, R.-P.13
-
10
-
-
34249829895
-
Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination
-
DOI 10.1128/JVI.00024-07
-
Velu V, Kannanganat S, Ibegbu C, et al. Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol 2007; 81:5819-5828. (Pubitemid 46847019)
-
(2007)
Journal of Virology
, vol.81
, Issue.11
, pp. 5819-5828
-
-
Velu, V.1
Kannanganat, S.2
Ibegbu, C.3
Chennareddi, L.4
Villinger, F.5
Freeman, G.J.6
Ahmed, R.7
Amara, R.R.8
-
11
-
-
0033137113
-
Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
-
Kuroda MJ, Schmitz JE, Charini WA, et al. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. J Immunol 1999; 162:5127-5133. (Pubitemid 29307114)
-
(1999)
Journal of Immunology
, vol.162
, Issue.9
, pp. 5127-5133
-
-
Kuroda, M.J.1
Schmitz, J.E.2
Charini, W.A.3
Nickerson, C.E.4
Lifton, M.A.5
Lord, C.I.6
Forman, M.A.7
Letvin, N.L.8
-
12
-
-
0035167278
-
+ T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques
-
DOI 10.1128/JVI.75.23.11483-11495.2001
-
Hel Z, Nacsa J, Kelsall B, et al. Impairment of Gag-specific CD8(\+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251-and simian-human immunodeficiency virus KU2-infected macaques. J Virol 2001; 75:11483-11495. (Pubitemid 33063240)
-
(2001)
Journal of Virology
, vol.75
, Issue.23
, pp. 11483-11495
-
-
Hel, Z.1
Nacsa, J.2
Kelsall, B.3
Tsai, W.-P.4
Letvin, N.5
Parks, R.W.6
Tryniszewska, E.7
Picker, L.8
Lewis, M.G.9
Edghill-Smith, Y.10
Moniuszko, M.11
Pal, R.12
Stevceva, L.13
Altman, J.D.14
Allen, T.M.15
Watkins, D.16
Torres, J.V.17
Berzofsky, J.A.18
Belyakov, I.M.19
Strober, W.20
Franchini, G.21
more..
-
13
-
-
0035130059
-
+ T cells during the chronic phase of infection
-
DOI 10.1128/JVI.75.5.2458-2461.2001
-
Vogel TU, Allen TM, Altman JD, Watkins DI. Functional impairment of simian immunodeficiency virus-specific CD8\+ T cells during the chronic phase of infection. J Virol 2001; 75:2458-2461. (Pubitemid 32147584)
-
(2001)
Journal of Virology
, vol.75
, Issue.5
, pp. 2458-2461
-
-
Vogel, T.U.1
Allen, T.M.2
Altman, J.D.3
Watkins, D.I.4
-
14
-
-
0035127132
-
+ T cells with a defect in effector function that is reversible on extended interleukin-2 incubation
-
DOI 10.1128/JVI.75.6.3028-3033.2001
-
Xiong Y, Luscher MA, Altman JD, et al. Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(\+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation. J Virol 2001; 75:3028-3033. (Pubitemid 32185070)
-
(2001)
Journal of Virology
, vol.75
, Issue.6
, pp. 3028-3033
-
-
Xiong, Y.1
Luscher, M.A.2
Altman, J.D.3
Hulsey, M.4
Robinson, H.L.5
Ostrowski, M.6
Barber, B.H.7
MacDonald, K.S.8
-
15
-
-
57849168934
-
Coregulation of CD8\+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
-
Blackburn SD, Shin H, Haining WN, et al. Coregulation of CD8\+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 2009; 10:29-37.
-
(2009)
Nat Immunol
, vol.10
, pp. 29-37
-
-
Blackburn, S.D.1
Shin, H.2
Haining, W.N.3
-
16
-
-
58149191881
-
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
-
Kinter AL, Godbout EJ, McNally JP, et al. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol 2008; 181:6738-6746.
-
(2008)
J Immunol
, vol.181
, pp. 6738-6746
-
-
Kinter, A.L.1
Godbout, E.J.2
McNally, J.P.3
-
17
-
-
73949113630
-
Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1
-
Salisch NC, Kaufmann DE, Awad AS, et al. Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1. J Immunol 2010; 184:476-487.
-
(2010)
J Immunol
, vol.184
, pp. 476-487
-
-
Salisch, N.C.1
Kaufmann, D.E.2
Awad, A.S.3
-
18
-
-
79955005750
-
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults
-
Duraiswamy J, Ibegbu CC, Masopust D, et al. Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. J Immunol 2011; 186:4200-4212.
-
(2011)
J Immunol
, vol.186
, pp. 4200-4212
-
-
Duraiswamy, J.1
Ibegbu, C.C.2
Masopust, D.3
-
19
-
-
84875538870
-
Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection
-
Hong JJ, Amancha PK, Rogers K, et al. Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection. PLoS One 2013; 8:e60186.
-
(2013)
PLoS One
, vol.8
-
-
Hong, J.J.1
Amancha, P.K.2
Rogers, K.3
-
20
-
-
0036114014
-
+ T cells and HIV-1-specific lymphoproliferation in HIV-1-infected subjects with active viral replication
-
DOI 10.1128/JVI.76.12.5925-5936.2002
-
Palmer BE, Boritz E, Blyveis N, Wilson CC. Discordance between frequency of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferonproducing CD4(\+) T cells and HIV-1-specific lymphoproliferation in HIV-1-infected subjects with active viral replication. J Virol 2002; 76:5925-5936. (Pubitemid 34556287)
-
(2002)
Journal of Virology
, vol.76
, Issue.12
, pp. 5925-5936
-
-
Palmer, B.E.1
Boritz, E.2
Blyveis, N.3
Wilson, C.C.4
-
21
-
-
0347911962
-
+ T Cells Endowed with Proliferative Capacity
-
DOI 10.1084/jem.20031598
-
Younes SA, Yassine-Diab B, Dumont AR, et al. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4\+ T cells endowed with proliferative capacity. J Exp Med 2003; 198:1909-1922. (Pubitemid 38032123)
-
(2003)
Journal of Experimental Medicine
, vol.198
, Issue.12
, pp. 1909-1922
-
-
Younes, S.-A.1
Yassine-Diab, B.2
Dumont, A.R.3
Boulassel, M.-R.4
Grossman, Z.5
Routy, J.-P.6
Sekaly, R.-P.7
-
22
-
-
34548637484
-
Programmed death 1 expression on HIV-specific CD4\+ T cells is driven by viral replication and associated with T cell dysfunction
-
D'Souza M, Fontenot AP, Mack DG, et al. Programmed death 1 expression on HIV-specific CD4\+ T cells is driven by viral replication and associated with T cell dysfunction. J Immunol 2007; 179:1979-1987.
-
(2007)
J Immunol
, vol.179
, pp. 1979-1987
-
-
D'Souza, M.1
Fontenot, A.P.2
MacK, D.G.3
-
23
-
-
78049401660
-
Regulation of virus-specific CD4\+ T cell function by multiple costimulatory receptors during chronic HIV infection
-
Kassu A, Marcus RA, D'Souza MB, et al. Regulation of virus-specific CD4\+ T cell function by multiple costimulatory receptors during chronic HIV infection. J Immunol 2010; 185:3007-3018.
-
(2010)
J Immunol
, vol.185
, pp. 3007-3018
-
-
Kassu, A.1
Marcus, R.A.2
D'Souza, M.B.3
-
24
-
-
84871844273
-
In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4\+ T cell levels in humanized mice
-
Palmer BE, Neff CP, Lecureux J, et al. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4\+ T cell levels in humanized mice. J Immunol 2013; 190:211-219.
-
(2013)
J Immunol
, vol.190
, pp. 211-219
-
-
Palmer, B.E.1
Neff, C.P.2
Lecureux, J.3
-
25
-
-
84886930547
-
PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads
-
Seung E, Dudek TE, Allen TM, et al. PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads. PLoS One 2013; 8:e77780.
-
(2013)
PLoS One
, vol.8
-
-
Seung, E.1
Dudek, T.E.2
Allen, T.M.3
-
26
-
-
84890331049
-
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4\+ and CD8\+ T cell responses but has limited clinical benefit
-
Amancha PK, Hong JJ, Rogers K, et al. In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4\+ and CD8\+ T cell responses but has limited clinical benefit. J Immunol 2013; 191:6060-6070.
-
(2013)
J Immunol
, vol.191
, pp. 6060-6070
-
-
Amancha, P.K.1
Hong, J.J.2
Rogers, K.3
-
27
-
-
62249172189
-
Enhancing SIV-specific immunity in vivo by PD-1 blockade
-
Velu V, Titanji K, Zhu B, et al. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 2009; 458:206-210.
-
(2009)
Nature
, vol.458
, pp. 206-210
-
-
Velu, V.1
Titanji, K.2
Zhu, B.3
-
28
-
-
84860584561
-
PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
-
Dyavar Shetty R, Velu V, Titanji K, et al. PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques. J Clin Invest 2012; 122:1712-1716.
-
(2012)
J Clin Invest
, vol.122
, pp. 1712-1716
-
-
Dyavar Shetty, R.1
Velu, V.2
Titanji, K.3
-
29
-
-
60549087784
-
PD-1 blockade in rhesus macaques: Impact on chronic infection and prophylactic vaccination
-
Finnefrock AC, Tang A, Li F, et al. PD-1 blockade in rhesus macaques: Impact on chronic infection and prophylactic vaccination. J Immunol 2009; 182:980-987.
-
(2009)
J Immunol
, vol.182
, pp. 980-987
-
-
Finnefrock, A.C.1
Tang, A.2
Li, F.3
-
30
-
-
47649115344
-
Species barrier of HIV-1 and its jumping by virus engineering
-
DOI 10.1002/rmv.576
-
Nomaguchi M, Doi N, Kamada K, Adachi A. Species barrier of HIV-1 and its jumping by virus engineering. Rev Med Virol 2008; 18:261-275. (Pubitemid 352018849)
-
(2008)
Reviews in Medical Virology
, vol.18
, Issue.4
, pp. 261-275
-
-
Nomaguchi, M.1
Doi, N.2
Kamada, K.3
Adachi, A.4
-
31
-
-
84867898654
-
Humanized mice for immune system investigation: Progress, promise and challenges
-
Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: Progress, promise and challenges. Nat Rev Immunol 2012; 12:786-798.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 786-798
-
-
Shultz, L.D.1
Brehm, M.A.2
Garcia-Martinez, J.V.3
Greiner, D.L.4
-
32
-
-
33751003823
-
HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/-(RAG-hu) mouse model
-
Berges BK, Wheat WH, Palmer BE, et al. HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/-(RAG-hu) mouse model. Retrovirology 2006; 3:76.
-
(2006)
Retrovirology
, vol.3
, pp. 76
-
-
Berges, B.K.1
Wheat, W.H.2
Palmer, B.E.3
-
33
-
-
67650410026
-
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virusinfected humanized BLT mice
-
Brainard DM, Seung E, Frahm N, et al. Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virusinfected humanized BLT mice. J Virol 2009; 83:7305-7321.
-
(2009)
J Virol
, vol.83
, pp. 7305-7321
-
-
Brainard, D.M.1
Seung, E.2
Frahm, N.3
-
34
-
-
33745959565
-
+ cell transplantation
-
DOI 10.1182/blood-2005-11-4388
-
Lan P, Tonomura N, Shimizu A, et al. Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34\+ cell transplantation. Blood 2006; 108:487-492 (Pubitemid 44061346)
-
(2006)
Blood
, vol.108
, Issue.2
, pp. 487-492
-
-
Lan, P.1
Tonomura, N.2
Shimizu, A.3
Wang, S.4
Yang, Y.-G.5
-
35
-
-
43249106514
-
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model
-
Tonomura N, Habiro K, Shimizu A, et al. Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 2008; 111:4293-4296.
-
(2008)
Blood
, vol.111
, pp. 4293-4296
-
-
Tonomura, N.1
Habiro, K.2
Shimizu, A.3
-
36
-
-
33846104485
-
null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses
-
DOI 10.1182/blood-2006-04-017681
-
Watanabe S, Terashima K, Ohta S, et al. Hematopoietic stem cell-engrafted NOD/SCID/IL2R gamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 2007; 109:212-218. (Pubitemid 46070123)
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 212-218
-
-
Watanabe, S.1
Terashima, K.2
Ohta, S.3
Horibata, S.4
Yajima, M.5
Shiozawa, Y.6
Zahidunnabi Dewan, M.7
Yu, Z.8
Ito, M.9
Morio, T.10
Shimizu, N.11
Honda, M.12
Yamamoto, N.13
-
37
-
-
1842588698
-
Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice
-
DOI 10.1126/science.1093933
-
Traggiai E, Chicha L, Mazzucchelli L, et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004; 304:104-107. (Pubitemid 38451466)
-
(2004)
Science
, vol.304
, Issue.5667
, pp. 104-107
-
-
Traggiai, E.1
Chicha, L.2
Mazzucchelli, L.3
Bronz, L.4
Piffaretti, J.-C.5
Lanzavecchia, A.6
Manz, M.G.7
-
38
-
-
49649114804
-
Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R, Rotem-Yehudar R, Slama G, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 2008; 14:3044-3051.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
-
39
-
-
77954899030
-
Phase i study of single-agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010; 28:3167-3175.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
40
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369:134-144.
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
-
41
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J MedV 366 2012; 2443-2454.
-
(2012)
N Engl J MedV
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
42
-
-
46349111534
-
Changes in the risk of death after HIV seroconversion compared with mortality in the general population
-
DOI 10.1001/jama.300.1.51
-
Bhaskaran K, Hamouda O, Sannes M, et al. Changes in the risk of death after HIV seroconversion compared with mortality in the general population. JAMAV 300 2008; 51-59. (Pubitemid 351920404)
-
(2008)
JAMA - Journal of the American Medical Association
, vol.300
, Issue.1
, pp. 51-59
-
-
Bhaskaran, K.1
Hamouda, O.2
Sannes, M.3
Boufassa, F.4
Johnson, A.M.5
Lambert, P.C.6
Porter, K.7
-
43
-
-
47649115323
-
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies
-
Hogg R, Lima V, Sterne JAC, et al. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies. Lancet 2008; 372:293-299.
-
(2008)
Lancet
, vol.372
, pp. 293-299
-
-
Hogg, R.1
Lima, V.2
Jac, S.3
-
44
-
-
84866498069
-
Redefining the viral reservoirs that prevent HIV-1 eradication
-
Eisele E, Siliciano RF. Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity 2012; 37:377-388.
-
(2012)
Immunity
, vol.37
, pp. 377-388
-
-
Eisele, E.1
Siliciano, R.F.2
-
45
-
-
62249095476
-
The challenge of finding a cure for HIV infection
-
Richman DD, Margolis DM, Delaney M, et al. The challenge of finding a cure for HIV infection. Science 2009; 323:1304-1307.
-
(2009)
Science
, vol.323
, pp. 1304-1307
-
-
Richman, D.D.1
Margolis, D.M.2
Delaney, M.3
-
46
-
-
84885195905
-
Immune targeting of PD-1(hi) expressing cells during and after antiretroviral therapy in SIV-infected rhesus macaques
-
Vargas-Inchaustegui DA, Xiao P, Hogg AE, et al. Immune targeting of PD-1(hi) expressing cells during and after antiretroviral therapy in SIV-infected rhesus macaques. Virology 2013; 447:274-284.
-
(2013)
Virology
, vol.447
, pp. 274-284
-
-
Vargas-Inchaustegui, D.A.1
Xiao, P.2
Hogg, A.E.3
-
47
-
-
84965033769
-
Dual approach to HIV-1 cure: Activation of latency and restoration of exhausted virus-specific T cell function
-
5 December 2013; Miami, Florida
-
Mason S, editor (2013). Dual approach to HIV-1 cure: Activation of latency and restoration of exhausted virus-specific T cell function. 6th HIV Persistence Workshop; 5 December 2013; Miami, Florida.
-
(2013)
6th HIV Persistence Workshop
-
-
Mason, S.1
-
48
-
-
84865416551
-
B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets
-
Mkrtichyan M, Najjar YG, Raulfs EC, et al. B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets. J Immunol 2012; 189:2338-2347.
-
(2012)
J Immunol
, vol.189
, pp. 2338-2347
-
-
Mkrtichyan, M.1
Najjar, Y.G.2
Raulfs, E.C.3
-
49
-
-
84875078589
-
Molecular signatures of T-cell inhibition in HIV-1 infection
-
Larsson M, Shankar EM, Che KF, et al. Molecular signatures of T-cell inhibition in HIV-1 infection. Retrovirology 2013; 10:31.
-
(2013)
Retrovirology
, vol.10
, pp. 31
-
-
Larsson, M.1
Shankar, E.M.2
Che, K.F.3
-
50
-
-
0036852170
-
CTLA-4-Ig regulates tryptophan catabolism in vivo
-
DOI 10.1038/ni846
-
Grohmann U, Orabona C, Fallarino F, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002; 3:1097-1101. (Pubitemid 35363664)
-
(2002)
Nature Immunology
, vol.3
, Issue.11
, pp. 1097-1101
-
-
Grohmann, U.1
Orabona, C.2
Fallarino, F.3
Vacca, C.4
Calcinaro, F.5
Falorni, A.6
Candeloro, P.7
Belladonna, M.L.8
Bianchi, R.9
Fioretti, M.C.10
Puccetti, P.11
-
51
-
-
0037040351
-
CTLA-4 upregulation during HIV infection: Association with anergy and possible target for therapeutic intervention
-
DOI 10.1097/00002030-200203080-00002
-
Leng Q, Bentwich Z, Magen E, et al. CTLA-4 upregulation during HIV infection: Association with anergy and possible target for therapeutic intervention. AIDS 2002; 16:519-529. (Pubitemid 34218846)
-
(2002)
AIDS
, vol.16
, Issue.4
, pp. 519-529
-
-
Leng, Q.1
Bentwich, Z.2
Magen, E.3
Kalinkovich, A.4
Borkow, G.5
-
52
-
-
0033564949
-
+ T cells in HIV-1-infected patients with progressing disease
-
Peritt D, Sesok-Pizzini DA, Schretzenmair R, et al. C1.7 antigen expression on CD8\+ T cells is activation dependent: Increased proportion of C1.7\+CD8\+ T cells in HIV-1-infected patients with progressing disease. J Immunol 1999; 162:7563-7568. (Pubitemid 29277738)
-
(1999)
Journal of Immunology
, vol.162
, Issue.12
, pp. 7563-7568
-
-
Peritt, D.1
Sesok-Pizzini, D.A.2
Schretzenmair, R.3
Macgregor, R.R.4
Valiante, N.M.5
Tu, X.6
Trinchieri, G.7
Kamoun, M.8
-
53
-
-
33846109307
-
CXCR4 or CCR5 tropism of human immunodeficiency virus type 1 isolates does not determine the immunological milieu in patients responding to antiretroviral therapy
-
DOI 10.1089/vim.2006.0055
-
Price P, Keane N, Gray L, et al. CXCR4 or CCR5 tropism of human immunodeficiency virus type 1 isolates does not determine the immunological milieu in patients responding to antiretroviral therapy. Viral Immunol 2006; 19:734-740. (Pubitemid 46068066)
-
(2006)
Viral Immunology
, vol.19
, Issue.4
, pp. 734-740
-
-
Price, P.1
Keane, N.2
Gray, L.3
Lee, S.4
Gorry, P.R.5
French, M.A.6
-
54
-
-
84863612769
-
Tim-3 negatively regulates cytotoxicity in exhausted CD8\+ T cells in HIV infection
-
Sakhdari A, Mujib S, Vali B, et al. Tim-3 negatively regulates cytotoxicity in exhausted CD8\+ T cells in HIV infection. PLoS One 2012; 7:e40146.
-
(2012)
PLoS One
, vol.7
-
-
Sakhdari, A.1
Mujib, S.2
Vali, B.3
-
55
-
-
84866176745
-
CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction
-
Peretz Y, He Z, Shi Y, et al. CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction. PLoS Pathog 2012; 8:e1002840.
-
(2012)
PLoS Pathog
, vol.8
-
-
Peretz, Y.1
He, Z.2
Shi, Y.3
-
56
-
-
84867609601
-
P38 mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells
-
Che KF, Shankar EM, Muthu S, et al. p38 mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells. Mol Med 2012; 18:1169-1182.
-
(2012)
Mol Med
, vol.18
, pp. 1169-1182
-
-
Che, K.F.1
Shankar, E.M.2
Muthu, S.3
-
57
-
-
56449128913
-
Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogenactivated protein kinase-dependent mechanism
-
Muthumani K, Choo AY, Shedlock DJ, et al. Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogenactivated protein kinase-dependent mechanism. J Virol 2008; 82:11536-11544.
-
(2008)
J Virol
, vol.82
, pp. 11536-11544
-
-
Muthumani, K.1
Choo, A.Y.2
Shedlock, D.J.3
-
58
-
-
58149314579
-
NFATc1 regulates PD-1 expression upon T cell activation
-
Oestreich KJ, Yoon H, Ahmed R, Boss JM. NFATc1 regulates PD-1 expression upon T cell activation. J Immunol 2008; 181:4832-4839.
-
(2008)
J Immunol
, vol.181
, pp. 4832-4839
-
-
Oestreich, K.J.1
Yoon, H.2
Ahmed, R.3
Boss, J.M.4
-
59
-
-
77957059176
-
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
-
Jin HT, Anderson AC, Tan WG, et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA 2010; 107:14733-14738.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14733-14738
-
-
Jin, H.T.1
Anderson, A.C.2
Tan, W.G.3
-
60
-
-
8644280556
-
+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
-
DOI 10.1182/blood-2004-01-0365
-
Weiss L, Donkova-Petrini V, Caccavelli L, et al. Human immunodeficiency virus-driven expansion of CD4\+CD25\+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004; 104:3249-3256. (Pubitemid 39507143)
-
(2004)
Blood
, vol.104
, Issue.10
, pp. 3249-3256
-
-
Weiss, L.1
Donkova-Petrini, V.2
Caccavelli, L.3
Balbo, M.4
Carbonneil, C.5
Levy, Y.6
-
61
-
-
35448968815
-
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
-
DOI 10.1128/JVI.00760-07
-
Boasso A, Vaccari M, Hryniewicz A, et al. Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. J Virol 2007; 81:11593-11603. (Pubitemid 47623791)
-
(2007)
Journal of Virology
, vol.81
, Issue.21
, pp. 11593-11603
-
-
Boasso, A.1
Vaccari, M.2
Hryniewicz, A.3
Fuchs, D.4
Nacsa, J.5
Cecchinato, V.6
Andersson, J.7
Franchini, G.8
Shearer, G.M.9
Chougnet, C.10
-
62
-
-
33750320502
-
Mucosal but not peripheral FOXP3\+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART
-
Epple HJ, Loddenkemper C, Kunkel D, et al. Mucosal but not peripheral FOXP3\+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 2006; 108:3072-3078.
-
(2006)
Blood
, vol.108
, pp. 3072-3078
-
-
Epple, H.J.1
Loddenkemper, C.2
Kunkel, D.3
-
63
-
-
33750310898
-
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
-
DOI 10.1182/blood-2006-05-021576
-
Nilsson J, Boasso A, Velilla PA, et al. HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood 2006; 108:3808-3817. (Pubitemid 44864563)
-
(2006)
Blood
, vol.108
, Issue.12
, pp. 3808-3817
-
-
Nilsson, J.1
Boasso, A.2
Velilla, P.A.3
Zhang, R.4
Vaccari, M.5
Franchini, G.6
Shearer, G.M.7
Andersson, J.8
Chougnet, C.9
-
64
-
-
22144487400
-
+ regulatory T cells in HIV infection
-
DOI 10.1016/j.micinf.2005.03.026, PII S1286457905001164
-
Nixon DF, Aandahl EM, Michaelsson J. CD4\+CD25\+ regulatory T cells in HIV infection. Microbes Infect 2005; 7:1063-1065. (Pubitemid 40982676)
-
(2005)
Microbes and Infection
, vol.7
, Issue.7-8
, pp. 1063-1065
-
-
Nixon, D.F.1
Aandahl, E.M.2
Michaelsson, J.3
-
65
-
-
20644434609
-
Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients
-
Tsunemi S, Iwasaki T, Imado T, et al. Relationship of CD4\+CD25\+ regulatory T cells to immune status in HIV-infected patients. AIDS 2005; 19:879-886. (Pubitemid 40834930)
-
(2005)
AIDS
, vol.19
, Issue.9
, pp. 879-886
-
-
Tsunemi, S.1
Iwasaki, T.2
Imado, T.3
Higasa, S.4
Kakishita, E.5
Shirasaka, T.6
Sano, H.7
-
66
-
-
45949087129
-
Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
-
Cecchinato V, Tryniszewska E, Ma ZM, et al. Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection. J Immunol 2008; 180:5439-5447.
-
(2008)
J Immunol
, vol.180
, pp. 5439-5447
-
-
Cecchinato, V.1
Tryniszewska, E.2
Ma, Z.M.3
-
67
-
-
79952294178
-
Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8\+ T cells and reduces chronic retroviral set points
-
Dietze KK, Zelinskyy G, Gibbert K, et al. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8\+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci USA 2011; 108:2420-2425.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 2420-2425
-
-
Dietze, K.K.1
Zelinskyy, G.2
Gibbert, K.3
-
68
-
-
84892856584
-
Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8\+ T cells and efficiently reduces chronic retroviral loads
-
Dietze KK, Zelinskyy G, Liu J, et al. Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8\+ T cells and efficiently reduces chronic retroviral loads. PLoS Pathog 2013; 9:e1003798.
-
(2013)
PLoS Pathog
, vol.9
-
-
Dietze, K.K.1
Zelinskyy, G.2
Liu, J.3
-
69
-
-
67651087322
-
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
-
Brockman MA, Kwon DS, Tighe DP, et al. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 2009; 114:346-356.
-
(2009)
Blood
, vol.114
, pp. 346-356
-
-
Brockman, M.A.1
Kwon, D.S.2
Tighe, D.P.3
-
70
-
-
0028267888
-
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus
-
Clerici M, Wynn TA, Berzofsky JA, et al. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994; 93:768-775. (Pubitemid 24072820)
-
(1994)
Journal of Clinical Investigation
, vol.93
, Issue.2
, pp. 768-775
-
-
Clerici, M.1
Wynn, T.A.2
Berzofsky, J.A.3
Blatt, S.P.4
Hendrix, C.W.5
Sher, A.6
Coffman, R.L.7
Shearer, G.M.8
-
71
-
-
84863993864
-
CD4\+ CD25\+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes
-
Kwon DS, Angin M, Hongo T, et al. CD4\+ CD25\+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes. J Virol 2012; 86:6586-6594.
-
(2012)
J Virol
, vol.86
, pp. 6586-6594
-
-
Kwon, D.S.1
Angin, M.2
Hongo, T.3
-
72
-
-
84896729257
-
Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions
-
Porichis F, Hart MG, Zupkosky J, et al. Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions. J Virol 2014; 88:2508-2518.
-
(2014)
J Virol
, vol.88
, pp. 2508-2518
-
-
Porichis, F.1
Hart, M.G.2
Zupkosky, J.3
|