The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo

Experimental Neurology

Volumn 261, Issue , 2014, Pages 501-509

  Wegleiter, Karina ^a   Hermann, Martin ^a   Posod, Anna ^a   Wechselberger, Karina ^a   Stanika, Ruslan I ^a   Obermair, Gerald J ^a   Kiechl Kohlendorfer, Ursula ^a   Urbanek, Martina ^a   Griesmaier, Elke ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Brain damage; Excitotoxicity; Microglia cell activation; Mitochondrial membrane potential; Preterm infant; Sigma receptor agonist

Indexed keywords

4 PHENYL 1 (4 PHENYLBUTYL) PIPERIDINE; CALCEIN; GLUTAMIC ACID; PIPERIDINE DERIVATIVE; PROPIDIUM IODIDE; UNCLASSIFIED DRUG; 4-PHENYL-1-(4-PHENYLBUTYL)PIPERIDINE; AMINO ACID RECEPTOR STIMULATING AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; GLYCOPROTEIN; HALOPERIDOL; IBOTENIC ACID; ISOLECTIN B4-BINDING GLYCOPROTEIN, MOUSE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN TOXICITY; CELL ACTIVATION; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXCITOTOXICITY; GRAY MATTER; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL NETWORK; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; WHITE MATTER; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; BRAIN INJURIES; CHEMICALLY INDUCED; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NERVE CELL; NONPARAMETRIC TEST; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BRAIN INJURIES; CASPASE 3; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; GLYCOPROTEINS; HALOPERIDOL; HIPPOCAMPUS; IBOTENIC ACID; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICROGLIA; NEURONS; RECEPTORS, SIGMA; STATISTICS, NONPARAMETRIC;

EID: 84905977146     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.07.022     Document Type: Article

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