A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 Engulfment and Cell Motility 1 (ELMO1) promotes Rac1 activation and cell motility

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 23112-23122

  Zhang, Guo ^a   Chen, Xia ^a   Qiu, Fanghua ^b   Zhu, Fengxin ^a   Lei, Wenjing ^a   Nie, Jing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; PROTEINS;

ACTIN CYTOSKELETON; ADAPTOR PROTEINS; CO-IMMUNOPRECIPITATION ASSAYS; CONSTITUTIVELY ACTIVES; RHO FAMILY GTPASES; SRC-FAMILY KINASE; TYROSINE PHOSPHATASE; TYROSINE PHOSPHORYLATION;

CELL SIGNALING;

ENGULFMENT AND CELL MOTILITY 1 PROTEIN; NCK PROTEIN; NCK1 PROTEIN; PROTEIN SH2; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; UNCLASSIFIED DRUG; ELMO1 PROTEIN, HUMAN; HCK PROTEIN, HUMAN; HEMATOPOIETIC CELL KINASE; ONCOPROTEIN; RAC1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ACTIN FILAMENT; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL MOTION; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; SRC HOMOLOGY DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SUBSTITUTION; CELL MOVEMENT; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-HCK; RAC1 GTP-BINDING PROTEIN; SRC HOMOLOGY DOMAINS;

EID: 84905963094     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.549550     Document Type: Article

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