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Volumn 6, Issue 8, 2014, Pages 3130-3152

Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese caucasian adults

Author keywords

BMI; Depression; Dietary intake; Eating behavior; Fat mass and obesity associated gene; FTO gene; Obesity; Physical activity; Psychological well being

Indexed keywords

ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CAUCASIAN; DIETARY INTAKE; FAT MASS; FAT MASS AND OBESITY ASSOCIATED GENE; FEEDING BEHAVIOR; FEMALE; GENE; GENERAL HEALTH QUESTIONNAIRE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPING TECHNIQUE; HUMAN; MALE; MENTAL HEALTH; OBESITY; PHYSICAL ACTIVITY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCORING SYSTEM; BODY WEIGHT; CALORIC INTAKE; CROSS-SECTIONAL STUDY; FOLLOW UP; GENE FREQUENCY; GENETICS; GENOTYPE; METABOLISM; MOTOR ACTIVITY; QUESTIONNAIRE; SOCIOECONOMICS;

EID: 84905924410     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6083130     Document Type: Article
Times cited : (80)

References (81)
  • 1
    • 33751079582 scopus 로고    scopus 로고
    • World Health Organization. Diet, Nutrition and the Prevention of Chronic Diseases, WHO Technical Report Series, No. 916; WHO: Geneva, Switzerland
    • World Health Organization. Diet, Nutrition and the Prevention of Chronic Diseases. Report for a Joint Who/Fao Expert Consultation; WHO Technical Report Series, No. 916; WHO: Geneva, Switzerland, 2003.
    • (2003) Report for a Joint Who/Fao Expert Consultation
  • 2
    • 84894272683 scopus 로고    scopus 로고
    • Available online: (accessed on 19 March 2014)
    • Obesity: Situation and Trends. Available online: http://www.who.int/gho/ncd/risk_factors/ obesity_text/en/index.html (accessed on 19 March 2014).
    • Obesity: Situation and Trends
  • 4
    • 40749085197 scopus 로고    scopus 로고
    • Genetic and environmental interactions in obesity and type 2 diabetes
    • Romao, I.; Roth, J. Genetic and environmental interactions in obesity and type 2 diabetes. J. Am. Diet. Assoc. 2008, 108, S24-S28.
    • (2008) J. Am. Diet. Assoc , vol.108
    • Romao, I.1    Roth, J.2
  • 10
    • 79952356805 scopus 로고    scopus 로고
    • Piecing together the FTO jigsaw
    • Frayling, T.M.; Ong, K. Piecing together the FTO jigsaw. Genome Biol. 2011, 12, 104.
    • (2011) Genome Biol , vol.12 , pp. 104
    • Frayling, T.M.1    Ong, K.2
  • 12
    • 39049154918 scopus 로고    scopus 로고
    • The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily
    • Sanchez-Pulido, L.; Andrade-Navarro, M.A. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem. 2007, 8, 23.
    • (2007) BMC Biochem , vol.8 , pp. 23
    • Sanchez-Pulido, L.1    Andrade-Navarro, M.A.2
  • 13
    • 77951623073 scopus 로고    scopus 로고
    • Crystal structure of the FTO protein reveals basis for its substrate specificity
    • Han, Z.; Niu, T.; Chang, J.; Lei, X.; Zhao, M.; Wang, Q.; Cheng, W.; Wang, J.; Feng, Y.; Chai, J. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 2010, 464, 1205-1209.
    • (2010) Nature , vol.464 , pp. 1205-1209
    • Han, Z.1    Niu, T.2    Chang, J.3    Lei, X.4    Zhao, M.5    Wang, Q.6    Cheng, W.7    Wang, J.8    Feng, Y.9    Chai, J.10
  • 14
    • 77953292057 scopus 로고    scopus 로고
    • The genetics of obesity: FTO leads the way
    • Fawcett, K.A.; Barroso, I. The genetics of obesity: FTO leads the way. Trends Genet. 2010, 26, 266-274.
    • (2010) Trends Genet , vol.26 , pp. 266-274
    • Fawcett, K.A.1    Barroso, I.2
  • 15
    • 54849381000 scopus 로고    scopus 로고
    • Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human
    • Jia, G.; Yang, C.; Yang, S.; Jian, X.; Yi, C.; Zhou, Z.; He, C. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008, 582, 3313-3319.
    • (2008) FTO. FEBS Lett , vol.582 , pp. 3313-3319
    • Jia, G.1    Yang, C.2    Yang, S.3    Jian, X.4    Yi, C.5    Zhou, Z.6    He, C.7
  • 19
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung, Y.C.; Ayuso, E.; Shan, X.; Bosch, F.; O'Rahilly, S.; Coll, A.P.; Yeo, G.S. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 2010, 5, e8771.
    • (2010) PLoS One , vol.5
    • Tung, Y.C.1    Ayuso, E.2    Shan, X.3    Bosch, F.4    O'Rahilly, S.5    Coll, A.P.6    Yeo, G.S.7
  • 21
    • 42949102733 scopus 로고    scopus 로고
    • The common rs9939609 gene variant of the fat mass-and obesity-associated gene FTO is related to fat cell lipolysis
    • Wåhlén, K.; Sjölin, E.; Hoffstedt, J. The common rs9939609 gene variant of the fat mass-and obesity-associated gene FTO is related to fat cell lipolysis. J. Lipid Res. 2008, 49, 607-611.
    • (2008) J. Lipid Res , vol.49 , pp. 607-611
    • Wåhlén, K.1    Sjölin, E.2    Hoffstedt, J.3
  • 24
    • 84877577199 scopus 로고    scopus 로고
    • FTO expression is regulated by availability of essential amino acids
    • Cheung, M.K.; Gulati, P.; O'Rahilly, S.; Yeo, G.S. FTO expression is regulated by availability of essential amino acids. Int. J. Obes. 2013, 37, 744-747.
    • (2013) Int. J. Obes , vol.37 , pp. 744-747
    • Cheung, M.K.1    Gulati, P.2    O'Rahilly, S.3    Yeo, G.S.4
  • 25
    • 84861884621 scopus 로고    scopus 로고
    • Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner
    • Pitman, R.T.; Fong, J.T.; Billman, P.; Puri, N. Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner. PLoS One 2012, 7, e38444.
    • (2012) PLoS One , vol.7
    • Pitman, R.T.1    Fong, J.T.2    Billman, P.3    Puri, N.4
  • 28
    • 78649512744 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
    • Gao, X.; Shin, Y.H.; Li, M.; Wang, F.; Tong, Q.; Zhang, P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 2010, 5, e14005.
    • (2010) PLoS One , vol.5
    • Gao, X.1    Shin, Y.H.2    Li, M.3    Wang, F.4    Tong, Q.5    Zhang, P.6
  • 29
    • 57749121512 scopus 로고    scopus 로고
    • An obesity-associated FTO gene variant and increased energy intake in children
    • Cecil, J.E.; Tavendale, R.; Watt, P.; Hetherington, M.M.; Palmer, C.N. An obesity-associated FTO gene variant and increased energy intake in children. N. Engl. J. Med. 2008, 359, 2558-2566.
    • (2008) N. Engl. J. Med , vol.359 , pp. 2558-2566
    • Cecil, J.E.1    Tavendale, R.2    Watt, P.3    Hetherington, M.M.4    Palmer, C.N.5
  • 30
    • 42449153273 scopus 로고    scopus 로고
    • Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
    • Do, R.; Bailey, S.D.; Desbiens, K.; Belisle, A.; Montpetit, A.; Bouchard, C.; Pérusse, L.; Vohl, M.C.; Engert, J.C. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 2008, 57, 1147-1150.
    • (2008) Diabetes , vol.57 , pp. 1147-1150
    • Do, R.1    Bailey, S.D.2    Desbiens, K.3    Belisle, A.4    Montpetit, A.5    Bouchard, C.6    Pérusse, L.7    Vohl, M.C.8    Engert, J.C.9
  • 32
    • 48749132799 scopus 로고    scopus 로고
    • Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    • Speakman, J.R.; Rance, K.A.; Johnstone, A.M. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity 2008, 16, 1961-1965.
    • (2008) Obesity , vol.16 , pp. 1961-1965
    • Speakman, J.R.1    Rance, K.A.2    Johnstone, A.M.3
  • 39
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller, S.A.; Dykes, D.D.; Polesky, H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988, 16, 1215.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 41
    • 0025039616 scopus 로고
    • Validation and comparison of eight physical activity questionnaires
    • Albanes, D.; Conway, J.M.; Taylor, P.R.; Moe, P.W.; Judd, J. Validation and comparison of eight physical activity questionnaires. Epidemiology 1990, 1, 65-71.
    • (1990) Epidemiology , vol.1 , pp. 65-71
    • Albanes, D.1    Conway, J.M.2    Taylor, P.R.3    Moe, P.W.4    Judd, J.5
  • 42
    • 0028348361 scopus 로고
    • Comparison of activity levels using the Caltrac accelerometer and five questionnaires
    • Miller, D.J.; Freedson, P.S.; Kline, G.M. Comparison of activity levels using the Caltrac accelerometer and five questionnaires. Med. Sci. Sports Exerc. 1994, 26, 376-382.
    • (1994) Med. Sci. Sports Exerc , vol.26 , pp. 376-382
    • Miller, D.J.1    Freedson, P.S.2    Kline, G.M.3
  • 43
    • 0029092249 scopus 로고
    • Ability of the atherosclerosis risk in communities (ARIC)/Baecke questionnaire to assess leisure-time physical activity
    • Richardson, M.T.; Ainsworth, B.E.; Wu, H.; Jacobs, D.R.; Leon, A.S. Ability of the atherosclerosis risk in communities (ARIC)/Baecke questionnaire to assess leisure-time physical activity. Int. J. Epidemiol. 1995, 24, 685-693.
    • (1995) Int. J. Epidemiol , vol.24 , pp. 685-693
    • Richardson, M.T.1    Ainsworth, B.E.2    Wu, H.3    Jacobs, D.R.4    Leon, A.S.5
  • 44
    • 0020417197 scopus 로고
    • A short questionnaire for the measurement of habitual physical activity in epidemiological studies
    • Baecke, J.A.H.; Burema, J.; Frijters, J.E.R. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am. J. Clin. Nutr. 1982, 36, 936-942.
    • (1982) Am. J. Clin. Nutr , vol.36 , pp. 936-942
    • Baecke, J.A.H.1    Burema, J.2    Frijters, J.E.R.3
  • 46
    • 0024840707 scopus 로고
    • A comparison of the validity of three scales for the assessment of dietary restraint
    • Laessle, R.G.; Tuschl, R.J.; Kotthaus, B.C.; Pirke, K.M. A comparison of the validity of three scales for the assessment of dietary restraint. J. Abnorm. Psychol. 1989, 98, 504-507.
    • (1989) J. Abnorm. Psychol , vol.98 , pp. 504-507
    • Laessle, R.G.1    Tuschl, R.J.2    Kotthaus, B.C.3    Pirke, K.M.4
  • 47
    • 0348133002 scopus 로고    scopus 로고
    • Eating behaviors and indexes of body composition in men and women from the Québec Family Study
    • Provencher, V.; Drapeau, V.; Tremblay, A.; Després, J.P.; Lemieux, S. Eating behaviors and indexes of body composition in men and women from the Québec Family Study. Obes. Res. 2003, 11, 783-792.
    • (2003) Obes. Res , vol.11 , pp. 783-792
    • Provencher, V.1    Drapeau, V.2    Tremblay, A.3    Després, J.P.4    Lemieux, S.5
  • 48
    • 0021989139 scopus 로고
    • The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
    • Stunkard, A.J.; Messick, S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J. Psychosom. Res. 1985, 29, 71-83.
    • (1985) J. Psychosom. Res , vol.29 , pp. 71-83
    • Stunkard, A.J.1    Messick, S.2
  • 49
    • 0032964441 scopus 로고    scopus 로고
    • Validation of the flexible and rigid control dimensions of dietary restraint
    • Westenhoefer, J.; Stunkard, A.J.; Pudel, V. Validation of the flexible and rigid control dimensions of dietary restraint. Int. J. Eat. Disord. 1999, 26, 53-64.
    • (1999) Int. J. Eat. Disord , vol.26 , pp. 53-64
    • Westenhoefer, J.1    Stunkard, A.J.2    Pudel, V.3
  • 50
    • 0034956287 scopus 로고    scopus 로고
    • The measurement of dietary restraint, disinhibition and hunger: An examination of the factor structure of the Three Factor Eating Questionnaire (TFEQ)
    • Bond, M.J.; McDowell, A.J.; Wilkinson, J.Y. The measurement of dietary restraint, disinhibition and hunger: An examination of the factor structure of the Three Factor Eating Questionnaire (TFEQ). Int. J. Obes. 2001, 25, 900-906.
    • (2001) Int. J. Obes , vol.25 , pp. 900-906
    • Bond, M.J.1    McDowell, A.J.2    Wilkinson, J.Y.3
  • 51
    • 56449122193 scopus 로고    scopus 로고
    • Self-efficacy and restrained eating in relation to weight loss among overweight men and women in Turkey
    • Bas, M.; Donmez, S. Self-efficacy and restrained eating in relation to weight loss among overweight men and women in Turkey. Appetite 2009, 52, 209-216.
    • (2009) Appetite , vol.52 , pp. 209-216
    • Bas, M.1    Donmez, S.2
  • 52
    • 70349519096 scopus 로고    scopus 로고
    • Risk factors for adult overweight and obesity in the Quebec Family Study: Have we been barking up the wrong tree?
    • Chaput, J.P.; Leblanc, C.; Perusse, L.; Despres, J.P.; Bouchard, C.; Tremblay, A. Risk factors for adult overweight and obesity in the Quebec Family Study: Have we been barking up the wrong tree? Obesity 2009, 17, 1964-1970.
    • (2009) Obesity , vol.17 , pp. 1964-1970
    • Chaput, J.P.1    Leblanc, C.2    Perusse, L.3    Despres, J.P.4    Bouchard, C.5    Tremblay, A.6
  • 54
    • 0004263384 scopus 로고    scopus 로고
    • The Psychological Corporation: San Antonio, TX, USA
    • Beck, A.T.; Steer, R.A.; Brown, G.K. BDI-II Manual; The Psychological Corporation: San Antonio, TX, USA, 1996.
    • (1996) BDI-II Manual
    • Beck, A.T.1    Steer, R.A.2    Brown, G.K.3
  • 57
    • 0020596477 scopus 로고
    • Validation of the General Health Questionnaire in a young community sample
    • Banks, M.H. Validation of the General Health Questionnaire in a young community sample. Psychol. Med. 1983, 13, 349-353.
    • (1983) Psychol. Med , vol.13 , pp. 349-353
    • Banks, M.H.1
  • 58
    • 0003131717 scopus 로고
    • Two objective measures of self-esteem
    • Lorr, M.; Wunderlich, R.A. Two objective measures of self-esteem. J. Pers. Assess. 1986, 50, 18-23.
    • (1986) J. Pers. Assess , vol.50 , pp. 18-23
    • Lorr, M.1    Wunderlich, R.A.2
  • 59
    • 0000261513 scopus 로고
    • Measurement of academic self-concept in college students
    • Reynolds, W.M. Measurement of academic self-concept in college students. J. Pers. Assess. 1988, 52, 223-240.
    • (1988) J. Pers. Assess , vol.52 , pp. 223-240
    • Reynolds, W.M.1
  • 62
    • 70350047277 scopus 로고    scopus 로고
    • Genetic variants in association studies-review of strengths and weaknesses in study design and current knowledge of impact on cancer risk
    • Andersson, U.; McKean-Cowdin, R.; Hjalmars, U.; Malmer, B. Genetic variants in association studies-review of strengths and weaknesses in study design and current knowledge of impact on cancer risk. Acta Oncol. 2009, 48, 948-954.
    • (2009) Acta Oncol , vol.48 , pp. 948-954
    • Andersson, U.1    McKean-Cowdin, R.2    Hjalmars, U.3    Malmer, B.4
  • 63
    • 1842539516 scopus 로고    scopus 로고
    • A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
    • Nyholt, D.R. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Hum. Genet. 2004, 74, 765-769.
    • (2004) Am. J. Hum. Genet , vol.74 , pp. 765-769
    • Nyholt, D.R.1
  • 64
    • 0032542897 scopus 로고    scopus 로고
    • What's wrong with Bonferroni adjustments
    • Perneger, T.V. What's wrong with Bonferroni adjustments. BMJ 1998, 316, 1236-1238.
    • (1998) BMJ , vol.316 , pp. 1236-1238
    • Perneger, T.V.1
  • 66
    • 77950663129 scopus 로고    scopus 로고
    • FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European-and African-American youth
    • Liu, G.; Zhu, H.; Lagou, V.; Gutin, B.; Stallmann-Jorgensen, I.S.; Treiber, F.A.; Dong, Y.; Snieder, H. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European-and African-American youth. BMC Med. Genet. 2010, 11, 57.
    • (2010) BMC Med. Genet , vol.11 , pp. 57
    • Liu, G.1    Zhu, H.2    Lagou, V.3    Gutin, B.4    Stallmann-Jorgensen, I.S.5    Treiber, F.A.6    Dong, Y.7    Snieder, H.8
  • 67
    • 70350686380 scopus 로고    scopus 로고
    • Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
    • Sonestedt, E.; Roos, C.; Gullberg, B.; Ericson, U.; Wirfält, E.; Orho-Melander, M. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am. J. Clin. Nutr. 2009, 90, 1418-1425.
    • (2009) Am. J. Clin. Nutr , vol.90 , pp. 1418-1425
    • Sonestedt, E.1    Roos, C.2    Gullberg, B.3    Ericson, U.4    Wirfält, E.5    Orho-Melander, M.6
  • 69
    • 65249089109 scopus 로고    scopus 로고
    • Restrained eating vs. "trying to lose weight": How are they associated with body weight and tendency to overeat among postmenopausal women?
    • Rideout, C.A.; Barr, S.I. "Restrained eating" vs. "trying to lose weight": How are they associated with body weight and tendency to overeat among postmenopausal women? J. Am. Diet. Assoc. 2009, 109, 890-893.
    • (2009) J. Am. Diet. Assoc , vol.109 , pp. 890-893
    • Rideout, C.A.1    Barr, S.I.2
  • 70
    • 67649884697 scopus 로고    scopus 로고
    • Dieting, restraint, and disinhibition predict women's weight change over 6 y
    • Savage, J.S.; Hoffman, L.; Birch, L.L. Dieting, restraint, and disinhibition predict women's weight change over 6 y. Am. J. Clin. Nutr. 2009, 90, 33-40.
    • (2009) Am. J. Clin. Nutr , vol.90 , pp. 33-40
    • Savage, J.S.1    Hoffman, L.2    Birch, L.L.3
  • 71
    • 0031856224 scopus 로고    scopus 로고
    • The eating inventory in obese women: Clinical correlates and relationship to weight loss
    • Foster, G.D.; Wadden, T.A.; Swain, R.M.; Stunkard, A.J.; Platte, P.; Vogt, R.A. The eating inventory in obese women: Clinical correlates and relationship to weight loss. Int. J. Obes. 1998, 22, 778-785.
    • (1998) Int. J. Obes , vol.22 , pp. 778-785
    • Foster, G.D.1    Wadden, T.A.2    Swain, R.M.3    Stunkard, A.J.4    Platte, P.5    Vogt, R.A.6
  • 73
    • 0037423144 scopus 로고    scopus 로고
    • Obesity and the environment: Where do we go from here?
    • Hill, J.O.; Wyatt, H.R.; Reed, G.W.; Peters, J.C. Obesity and the environment: Where do we go from here? Science 2003, 299, 853-855.
    • (2003) Science , vol.299 , pp. 853-855
    • Hill, J.O.1    Wyatt, H.R.2    Reed, G.W.3    Peters, J.C.4
  • 74
    • 49649110625 scopus 로고    scopus 로고
    • Disinhibition: Its effects on appetite and weight regulation
    • Bryant, E.J.; King, N.A.; Blundell, J.E. Disinhibition: Its effects on appetite and weight regulation. Obes. Rev. 2008, 9, 409-419.
    • (2008) Obes. Rev , vol.9 , pp. 409-419
    • Bryant, E.J.1    King, N.A.2    Blundell, J.E.3
  • 77
    • 67649560777 scopus 로고    scopus 로고
    • Psychobiological traits in the risk profile for overeating and weight gain
    • Davis, C. Psychobiological traits in the risk profile for overeating and weight gain. Int. J. Obes. 2009, 33 (Suppl. 2), S49-S53.
    • (2009) Int. J. Obes , vol.33 , Issue.SUPPL. 2
    • Davis, C.1
  • 79
  • 81
    • 39749116842 scopus 로고    scopus 로고
    • FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs
    • Price, R.A.; Li, W.D.; Zhao, H. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC Med. Genet. 2008, 9, 4.
    • (2008) BMC Med. Genet , vol.9 , pp. 4
    • Price, R.A.1    Li, W.D.2    Zhao, H.3


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