Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X3 inhibits the release of a pain mediator

Biochemical Journal

Volumn 462, Issue 2, 2014, Pages 247-256

  Ma, Hui ^a   Meng, Jianghui ^a   Wang, Jiafu ^a   Hearty, Stephen ^a   Dolly, J Oliver ^a   O'Kennedy, Richard ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Botulinum neurotoxin type A (BoNT A); Inflammatory pain; Phage display; Single chain Fv fragment (scFv); Targeted delivery

Indexed keywords

ANIMALS; BOTULINUM TOXINS, TYPE A; CALCITONIN GENE-RELATED PEPTIDE; CELLS, CULTURED; FEMALE; GANGLIA, SPINAL; HUMANS; MICE; PAIN; RABBITS; RATS; RECEPTORS, PURINERGIC P2X3; RECOMBINANT FUSION PROTEINS; SENSORY RECEPTOR CELLS; SINGLE-CHAIN ANTIBODIES; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;

EID: 84905922216     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131387     Document Type: Article

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