A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: Transfer of longevity to a novel potential therapeutic

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6375-6385

  Wang, Jiafu ^a   Zurawski, Tomas H ^a   Meng, Jianghui ^a   Lawrence, Gary ^a   Olango, Weredeselam M ^b   Finn, David P ^b   Wheeler, Larry ^c   Dolly, J Oliver ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM NEUROTOXIN TYPE A; BOTULINUM TOXIN A; C TERMINUS; CALCITONIN GENE-RELATED PEPTIDES; CEREBELLAR NEURONS; CLOSTRIDIUM BOTULINUM; FAST RECOVERY; IN-VIVO; INACTIVE MUTANTS; LIGHT CHAIN; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; SENSORY NEURONS; STRUCTURAL BASIS; THERAPEUTIC POTENTIALS; TRANSIENT RECEPTOR POTENTIAL VANILLOID;

AMINO ACIDS; CLOSTRIDIUM; GENES; HYDROLASES;

NEURONS;

BOTULINUM TOXIN A; BOTULINUM TOXIN E; CALCITONIN GENE RELATED PEPTIDE; LEUCINE; PROTEINASE; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN NERVE CELL; CARBOXY TERMINAL SEQUENCE; CEREBELLUM; CONTROLLED STUDY; DRUG POTENCY; EXOCYTOSIS; FEMALE; IN VIVO STUDY; MOUSE; NEUROMUSCULAR TRANSMISSION; NEUROTOXICITY; NEUROTROPISM; NONHUMAN; PAIN; PARALYSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; SENSORY NERVE CELL;

ANIMALS; BOTULINUM TOXINS, TYPE A; CALCITONIN; CEREBELLUM; FEMALE; LEUCINE; MALE; MICE; MUTATION; NEUROMUSCULAR AGENTS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SENSORY RECEPTOR CELLS; SYNAPTIC TRANSMISSION; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TIME FACTORS;

CLOSTRIDIUM BOTULINUM; RATTUS;

EID: 79953184288     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.181784     Document Type: Article

References (39)

1. Dolly, J. O., Lawrence, G. W., Meng, J., Wang, J., and Ovsepian, S. V. (2009) Curr. Opin. Pharmacol. 9, 326-335
2. Dong, M., Yeh, F., Tepp, W. H., Dean, C., Johnson, E. A., Janz, R., and Chapman, E. R. (2006) Science 312, 592-596
3. Mahrhold, S., Rummel, A., Bigalke, H., Davletov, B., and Binz, T. (2006) FEBS Lett. 580, 2011-2014
4. Dong, M., Liu, H., Tepp, W. H., Johnson, E. A., Janz, R., and Chapman, E. R. (2008) Mol. Biol. Cell 19, 5226-5237
5. Meng, J., Ovsepian, S. V., Wang, J., Pickering, M., Sasse, A., Aoki, K. R., Lawrence, G. W., and Dolly, J. O. (2009) J. Neurosci. 29, 4981-4992
6. Dolly, J. O., Black, J., Williams, R. S., and Melling, J. (1984) Nature 307, 457-460
7. Black, J. D., and Dolly, J. O. (1986) J. Cell Biol. 103, 535-544
8. Dolly, J. O., and Lawrence, G. (2007) in Clinical Uses of Botulinum Toxins (Ward, A. B., and Barnes, M. B., eds) pp. 9-26, Cambridge University Press, Cambridge
9. Keller, J. E., Neale, E. A., Oyler, G., and Adler, M. (1999) FEBS Lett. 456, 137-142
10. Adler, M., Keller, J. E., Sheridan, R. E., and Deshpande, S. S. (2001) Toxicon 39, 233-243
11. Ward, A. B., and Barnes, M. P. (2007) Clinical Uses of Botulinum Toxins, pp. 1-384, Cambridge University Press, Cambridge
12. Dodick, D. W., Turkel, C. C., DeGryse, R. E., Aurora, S. K., Silberstein, S. D., Lipton, R. B., Diener, H. C., and Brin, M. F. (2010) Headache 50, 921-936
13. Cull-Candy, S. G., Lundh, H., and Thesleff, S. (1976) J. Physiol. 260, 177-203
14. Molgó, J., Lundh, H., and Thesleff, S. (1980) Eur. J. Pharmacol. 61, 25-34
15. Meunier, F. A., Lisk, G., Sesardic, D., and Dolly, J. O. (2003) Mol. Cell Neurosci. 22, 454-466
16. Lawrence, G., Wang, J., Chion, C. K., Aoki, K. R., and Dolly, J. O. (2007) J. Pharmacol. Exp. Ther. 320, 410-418
17. Sloop, R. R., Cole, B. A., and Escutin, R. O. (1997) Neurology 49, 189-194
18. Eleopra, R., Tugnoli, V., Rossetto, O., De Grandis, D., and Montecucco, C. (1998) Neurosci. Lett. 256, 135-138
19. Foran, P. G., Mohammed, N., Lisk, G. O., Nagwaney, S., Lawrence, G. W., Johnson, E., Smith, L., Aoki, K. R., and Dolly, J. O. (2003) J. Biol. Chem. 278, 1363-1371
20. Fernández-Salas, E., Steward, L. E., Ho, H., Garay, P. E., Sun, S. W., Gilmore, M. A., Ordas, J. V., Wang, J., Francis, J., and Aoki, K. R. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 3208-3213
21. Rummel, A., Karnath, T., Henke, T., Bigalke, H., and Binz, T. (2004) J. Biol. Chem. 279, 30865-30870
22. Wang, J., Meng, J., Lawrence, G. W., Zurawski, T. H., Sasse, A., Bodeker, M. O., Gilmore, M. A., Fernández-Salas, E., Francis, J., Steward, L. E., Aoki, K. R., and Dolly, J. O. (2008) J. Biol. Chem. 283, 16993-17002
23. Studier, F. W. (2005) Protein Expression Purif. 41, 207-234
24. Meng, J., Wang, J., Lawrence, G., and Dolly, J. O. (2007) J. Cell Sci. 120, 2864-2874
25. Lawrence, G. W., and Dolly, J. O. (2002) J. Cell Sci. 115, 2791-2800
26. Aoki, K. R. (2001) Toxicon 39, 1815-1820
27. Maisey, E. A., Wadsworth, J. D., Poulain, B., Shone, C. C., Melling, J., Gibbs, P., Tauc, L., and Dolly, J. O. (1988) Eur. J. Biochem. 177, 683-691
28. Honda, K., Kitagawa, J., Sessle, B. J., Kondo, M., Tsuboi, Y., Yonehara, Y., and Iwata, K. (2008) Mol. Pain 4, 59
29. Kim, H. Y., Wang, J., Lee, I., Kim, H. K., Chung, K., and Chung, J. M. (2009) Pain 145, 332-340
30. Kim, S. H., and Ryan, T. A. (2009) J. Biol. Chem. 284, 32803-32812
31. Stoka, V., Turk, B., Schendel, S. L., Kim, T. H., Cirman, T., Snipas, S. J., Ellerby, L. M., Bredesen, D., Freeze, H., Abrahamson, M., Bromme, D., Krajewski, S., Reed, J. C., Yin, X. M., Turk, V., and Salvesen, G. S. (2001) J. Biol. Chem. 276, 3149-3157
32. Shi, X., Curran, J. E., Liao, Z., and Gordon, R. K. (2009) J. Cell. Biochem. 108, 660-667
33. Fischer, A., and Montal, M. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 10447-10452
34. Montal, M. (2010) Annu. Rev. Biochem. 79, 591-617
35. Bade, S., Rummel, A., Reisinger, C., Karnath, T., Ahnert-Hilger, G., Bigalke, H., and Binz, T. (2004) J. Neurochem. 91, 1461-1472
36. Jakubowski, M., McAllister, P. J., Bajwa, Z. H., Ward, T. N., Smith, P., and Burstein, R. (2006) Pain 125, 286-295
37. Costantin, L., Bozzi, Y., Richichi, C., Viegi, A., Antonucci, F., Funicello, M., Gobbi, M., Mennini, T., Rossetto, O., Montecucco, C., Maffei, L., Vezzani, A., and Caleo, M. (2005) J. Neurosci. 25, 1943-1951
38. Christoph, T., Gillen, C., Mika, J., Grünweller, A., Schäfer, M. K., Schiene, K., Frank, R., Jostock, R., Bahrenberg, G., Weihe, E., Erdmann, V. A., and Kurreck, J. (2007) Neurochem. Int. 50, 281-290
39. Witting, N., Svensson, P., Gottrup, H., Arendt-Nielsen, L., and Jensen, T. S. (2000) Pain 84, 407-412