Synthesis and bioactivity of novel amino-pyrazolopyridines

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 450-457

  Orlikova, Barbora ^a,b   Chaouni, Wafaa ^c,d   Schumacher, Marc ^a   Aadil, Mina ^d   Diederich, Marc ^b   Kirsch, Gilbert ^d  

^a LABORATOIRE DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE DU CANCER   (Luxembourg)

^b Seoul National University   (South Korea)

^c UNIVERSITÉ DE LORRAINE   (France)

^d HASSAN II UNIVERSITY OF CASABLANCA   (Morocco)

Author keywords

Amino pyrazolopyridine; Apoptosis; Cancer; Inflammation; NF B pathway; Vilsmeier Haack

Indexed keywords

AMINOPYRAZOLOPYRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; HYDRAZINE; I KAPPA B; MALONONITRILE; UNCLASSIFIED DRUG; 3,6,7,8 TETRAHYDROCYCLOPENTA[D]PYRAZOLO[3,4 B]PYRIDIN 1 AMINE; 4 ETHYL 5 METHYL 1H PYRAZOLO[3,4 B]PYRIDIN 3 AMINE; 5 METHYL 4 PHENYL 1H PYRAZOLO[3,4 B]PYRIDIN 3 AMINE; 6,7 DIHYDRO 3H BENZO[F]PYRAZOLO[3,4 C]ISOQUINOLIN 1 AMINE; 6,7,8,9 TETRAHYDRO 3H PYRAZOLO[3,4 C]ISOQUINOLIN 1 AMINE; 7 METHYL 6 HYDRO 3H BENZO[F]PYRAZOLO[3,4 C]ISOQUINOLIN 1 AMINE; 7 METHYL 6,7,8,9 TETRAHYDRO 3H PYARAZOLO[3,4 C]ISOQUINOLIN 1 AMINE; ALPHA METHYLENE KETONE DERIVATIVE; AMINO PYRAZOLOPYRIDINE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; APOPTOSIS INDUCING FACTOR; CURCUMIN; CYTOTOXIC AGENT; ETOPOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETONE DERIVATIVE; PYRAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; KETONE; PYRAZOLOPYRIDINE; PYRIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL DEATH; CYCLIZATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; K562 CELL LINE; PERIPHERAL BLOOD MONONUCLEAR CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; CELL ACTIVATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DONOR; DRUG CYTOTOXICITY; IC50; KNOEVENAGEL CONDENSATION; VILSMEIER HAACK REACTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; KETONES; NF-KAPPA B; PYRAZOLES; PYRIDINES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84905856106     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.008     Document Type: Article

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