Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4273-4278

  Shi, Jianyou ^a,b   Xu, Guobin ^a   Zhu, Wei ^a   Ye, Haoyu ^a   Yang, Shengyong ^a   Luo, Youfu ^a   Han, Jing ^a   Yang, Jincheng ^a,b   Li, Rui ^a,c   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

1,4,5,6 Tetrahydropyrrolo 3,4 c pyrazoles; Antitumor; Aurora A kinase; Pyrazolo 3,4 b pyridines

Indexed keywords

1,4,5,6 TETRAHYDROPYRROLO[3,4 C]PYRAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA KINASE INHIBITOR; DANUSERTIB; PYRAZOLO[3,4 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL STRAIN HCT116; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR DOCKING; TUMOR CELL LINE;

CELL LINE, TUMOR; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES;

EID: 77954142426     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.083     Document Type: Article

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