TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

DMM Disease Models and Mechanisms

Volumn 7, Issue 8, 2014, Pages 987-996

  Munjal, Charu ^a   Opoka, Amy M ^a   Osinska, Hanna ^a   James, Jeanne F ^a   Bressan, Giorgio M ^b   Hinton, Robert B ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Angiogenesis; Aortic valve; Elastic fibers; Extracellular matrix; Fibrosis

Indexed keywords

ELASTIN MICROFIBRIL INTERFACE LOCATED PROTEIN; MEMBRANE PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; AORTA VALVE; BIOLOGICAL MODEL; CALCINOSIS; CELL PROLIFERATION; COMPLICATION; CONGENITAL HEART MALFORMATION; CUTIS LAXA; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; ECHOGRAPHY; ELASTIC TISSUE; FIBROSIS; INFLAMMATION; METABOLISM; MOUSE; MYOFIBROBLAST; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SIGNAL TRANSDUCTION; ULTRASTRUCTURE; VALVULAR HEART DISEASE;

ANIMALS; AORTIC VALVE; CALCINOSIS; CELL PROLIFERATION; CUTIS LAXA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELASTIC TISSUE; FIBROSIS; HEART DEFECTS, CONGENITAL; HEART VALVE DISEASES; INFLAMMATION; MEMBRANE GLYCOPROTEINS; MICE; MODELS, BIOLOGICAL; MYOFIBROBLASTS; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84905820633     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.015255     Document Type: Article

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