Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease

Matrix Biology

Volumn 31, Issue 3, 2012, Pages 197-205

  Krishnamurthy, Varun K ^a,d   Opoka, Amy M ^a   Kern, Christine B ^b   Guilak, Farshid ^c   Narmoneva, Daria A ^d   Hinton, Robert B ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d 705 Engineering Research Center   (United States)

Author keywords

Aortic valve annulus; Biomedical engineering; Elastin haploinsufficiency; Micropipette aspiration; Valve development

Indexed keywords

ADAMTS1 PROTEIN; GELATIN; GELATINASE A; GELATINASE B; VERSICAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ANOMALY; AORTA VALVE; AORTA VALVE DISEASE; AORTA VALVE MALFORMATION; ARTICLE; ASPIRATION; BIOMECHANICS; CARTILAGE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; MICROPIPETTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; ZYMOGRAPHY;

ADAM PROTEINS; ANIMALS; AORTIC DISEASES; AORTIC VALVE; BIOMECHANICS; DISEASE MODELS, ANIMAL; ELASTIN; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; HAPLOINSUFFICIENCY; HEART VALVE DISEASES; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; STRUCTURE-ACTIVITY RELATIONSHIP; TENSILE STRENGTH; VERSICANS;

MUS;

EID: 84857783542     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2012.01.001     Document Type: Article

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