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Volumn 10, Issue 3, 2014, Pages 164-174

Paradigm shifts in thyroid hormone replacement therapies for hypothyroidism

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LEVOTHYROXINE; LIOTHYRONINE; THYROID HORMONE; THYROTROPIN; THYROXINE;

EID: 84905723129     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2013.258     Document Type: Review
Times cited : (82)

References (99)
  • 1
    • 0017878711 scopus 로고
    • Why does anyone still use desiccated thyroid USP?
    • Jackson, I. M. & Cobb, W. E. Why does anyone still use desiccated thyroid USP? Am. J. Med. 64, 284-288 (1978).
    • (1978) Am. J. Med. , vol.64 , pp. 284-288
    • Jackson, I.M.1    Cobb, W.E.2
  • 2
    • 0028926303 scopus 로고
    • Treatment guidelines for patients with hyperthyroidism and hypothyroidism. Standards of Care Committee American Thyroid Association
    • Singer, P. A. et al. Treatment guidelines for patients with hyperthyroidism and hypothyroidism. Standards of Care Committee, American Thyroid Association. JAMA 273, 808-812 (1995).
    • (1995) JAMA , vol.273 , pp. 808-812
    • Singer, P.A.1
  • 3
    • 0029815604 scopus 로고    scopus 로고
    • The Research Unit of the Royal College of Physicians of London, the Endocrinology and Diabetes Committee of the Royal College of Physicians of London, and the Society for Endocrinology
    • Vanderpump, M. P. J., Ahlquist, J. A. O., Franklyn, J. A. & Clayton, R. N., Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. The Research Unit of the Royal College of Physicians of London, the Endocrinology and Diabetes Committee of the Royal College of Physicians of London, and the Society for Endocrinology. BMJ 313, 539-544 (1996).
    • (1996) BMJ , vol.313 , pp. 539-544
    • Vanderpump, M.P.J.1    Ahlquist, J.A.O.2    Franklyn, J.A.3    Clayton, R.N.4
  • 4
    • 0036858505 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism
    • Baskin, H. J. et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr. Pract. 8, 457-469 (2002).
    • (2002) Endocr. Pract. , vol.8 , pp. 457-469
    • Baskin, H.J.1
  • 5
    • 84908188306 scopus 로고    scopus 로고
    • Royal College of Physicians. The diagnosis and management of primary hypothyroidism, revised 14 June 2011 [online]
    • Royal College of Physicians. The diagnosis and management of primary hypothyroidism, revised 14 June 2011 [online], http://www.rcplondon.ac.uk/sites/default/files/the-diagnosis-and-management-of-primary-hypothyroidism-revised-statement-14-june-2011-2.pdf (2011).
    • (2011)
  • 6
    • 84870784432 scopus 로고    scopus 로고
    • Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    • Garber, J. R. et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid 22, 1200-1235 (2012).
    • (2012) Thyroid , vol.22 , pp. 1200-1235
    • Garber, J.R.1
  • 7
    • 84880020502 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of hypothyroidism
    • Brenta, G. et al. Clinical practice guidelines for the management of hypothyroidism. Arq. Bras. Endocrinol. Metabol. 57, 265-291 (2013).
    • (2013) Arq. Bras. Endocrinol. Metabol. , vol.57 , pp. 265-291
    • Brenta, G.1
  • 9
  • 10
    • 84908221696 scopus 로고    scopus 로고
    • 3 in the Dutch population in the period 2005-2011
    • 3 in the Dutch population in the period 2005-2011. Eur. Thyroid J. 1, 135-136 (2012).
    • (2012) Eur. Thyroid J. , vol.1 , pp. 135-136
    • De Jong, N.W.1    Baljet, G.M.2
  • 11
    • 0006101967 scopus 로고
    • Report of a committee of the Clinical Society of London nominated December 14, 1883, to investigate the subject of myxoedema
    • Ord, W. M. Report of a committee of the Clinical Society of London nominated December 14, 1883, to investigate the subject of myxoedema. Trans. Clin. Soc. Lond. 8 (Suppl.), 21 (1888).
    • (1888) Trans. Clin. Soc. Lond. , vol.8 , pp. 21
    • Ord, W.M.1
  • 12
    • 84965340960 scopus 로고
    • Note on the treatment of myxoedema by hypodermic injections of an extract of the thyroid gland of a sheep
    • Murray, G. R. Note on the treatment of myxoedema by hypodermic injections of an extract of the thyroid gland of a sheep. Br. Med. J. 2, 796-797 (1891).
    • (1891) Br. Med. J. , vol.2 , pp. 796-797
    • Murray, G.R.1
  • 13
    • 1642397161 scopus 로고
    • A case of myxoedema treated by taking extract of thyroid by the mouth
    • Fox, E. L. A case of myxoedema treated by taking extract of thyroid by the mouth. Br. Med. J. 2, 941 (1892).
    • (1892) Br. Med. J. , vol.2 , pp. 941
    • Fox, E.L.1
  • 14
    • 84943211433 scopus 로고
    • The isolation in crystalline form of the compound containing iodin, which occurs in the thyroid: Its chemical nature and physiological activity
    • Kendall, E. C. The isolation in crystalline form of the compound containing iodin, which occurs in the thyroid: its chemical nature and physiological activity. JAMA 64, 2042-2043 (1915).
    • (1915) JAMA , vol.64 , pp. 2042-2043
    • Kendall, E.C.1
  • 15
    • 0001538947 scopus 로고
    • Chemistry of thyroxine: Constitution and synthesis of thyroxine
    • Harrington, C. R. & Barger, G. Chemistry of thyroxine: constitution and synthesis of thyroxine. Biochem. J. 21, 169-183 (1927).
    • (1927) Biochem. J. , vol.21 , pp. 169-183
    • Harrington, C.R.1    Barger, G.2
  • 16
    • 27644454644 scopus 로고    scopus 로고
    • The heritage of the thyroid: A brief history
    • (eds Braverman, L. E. & Cooper, D. S.) Lippincott Williams & Wilkins
    • th edn (eds Braverman, L. E. & Cooper, D. S.) 1-4 (Lippincott Williams & Wilkins, 2013).
    • (2013) th Edn , pp. 1-4
    • Sawin, C.S.1
  • 17
    • 0013627622 scopus 로고
    • 3: 5:3'-triiodothyronine. I. Isolation from thyroid gland and synthesis
    • Gross, J. & Pitt-Rivers, R. V. 3:5:3'-triiodothyronine. I. Isolation from thyroid gland and synthesis. Biochem. J. 53, 645-650 (1953).
    • (1953) Biochem. J. , vol.53 , pp. 645-650
    • Gross, J.1    Pitt-Rivers, R.V.2
  • 18
    • 3242826886 scopus 로고
    • Sur la présence de triiodothyronine dans la thyroglobuline et sur sa biosynthèse [French]
    • Roche, J., Lissitzky, S. & Michel, R. Sur la présence de triiodothyronine dans la thyroglobuline et sur sa biosynthèse [French]. C. R. Hebd. Seances Acad. Sci. 234, 1228-1230 (1952).
    • (1952) C. R. Hebd. Seances Acad. Sci. , vol.234 , pp. 1228-1230
    • Roche, J.1    Lissitzky, S.2    Michel, R.3
  • 19
    • 0001264150 scopus 로고
    • Why does anybody use thyroid B.P.?
    • MacGregor, A. G. Why does anybody use thyroid B.P.? Lancet 1, 329-332 (1961).
    • (1961) Lancet , vol.1 , pp. 329-332
    • Macgregor, A.G.1
  • 21
    • 0026366087 scopus 로고
    • Thyroid hormone use: Trends in the United States from 1960 through 1988
    • Kaufman, S. C., Gross, T. P. & Kennedy, D. L. Thyroid hormone use: trends in the United States from 1960 through 1988. Thyroid 1, 285-291 (1991).
    • (1991) Thyroid , vol.1 , pp. 285-291
    • Kaufman, S.C.1    Gross, T.P.2    Kennedy, D.L.3
  • 22
    • 0036191639 scopus 로고    scopus 로고
    • Biochemistry, cellular and molecular biology and physiological roles of the iodothyronine selenodeiodinases
    • Bianco, A. C. et al. Biochemistry, cellular and molecular biology and physiological roles of the iodothyronine selenodeiodinases. Endocr. Rev. 23, 38-89 (2002).
    • (2002) Endocr. Rev. , vol.23 , pp. 38-89
    • Bianco, A.C.1
  • 23
    • 0043026914 scopus 로고    scopus 로고
    • Intrinsic imperfections of endocrine replacement therapy
    • Romijn, J. A., Smit, J. W. & Lamberts, S. W. Intrinsic imperfections of endocrine replacement therapy. Eur. J. Endocrinol. 149, 91-97 (2003).
    • (2003) Eur. J. Endocrinol. , vol.149 , pp. 91-97
    • Romijn, J.A.1    Smit, J.W.2    Lamberts, S.W.3
  • 24
    • 0028861989 scopus 로고
    • Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats
    • Escobar-Morreale, H. F., Obregón, M. J., Escobar del Rey, F. & Morreale de Escobar, G. Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. J. Clin. Invest. 96, 2828-2838 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 2828-2838
    • Escobar-Morreale, H.F.1    Obregón, M.J.2    Escobar Del Rey, F.3    Morreale De Escobar, G.4
  • 25
    • 0029938145 scopus 로고    scopus 로고
    • Only the combined treatment with thyroxine and triiiodothyronine ensures euthyroidism in all tissues of thyroidectomized rat
    • Escobar-Morreale, H. F., Escobar del Rey, F., Obregón, M. J. & Morreale de Escobar, G. Only the combined treatment with thyroxine and triiiodothyronine ensures euthyroidism in all tissues of thyroidectomized rat. Endocrinology 137, 2490-2502 (1996).
    • (1996) Endocrinology , vol.137 , pp. 2490-2502
    • Escobar-Morreale, H.F.1    Escobar Del Rey, F.2    Obregón, M.J.3    Morreale De Escobar, G.4
  • 26
    • 84908188305 scopus 로고    scopus 로고
    • Hypo maar niet Happy: belangenvereniging voor mensen met hypothyreoïdie [online]
    • Hypo maar niet Happy: belangenvereniging voor mensen met hypothyreoïdie [online], www.hypomaarniethappy.nl (2013).
    • (2013)
  • 27
    • 33745768179 scopus 로고    scopus 로고
    • Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: Meta-analysis of randomized controlled trials
    • Grozinsky-Glasberg, S., Fraser, A., Nahshoni, E., Weizman, A. & Leibovici, L. Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials. J. Clin. Endocrinol. Metab. 91, 2592-2599 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 2592-2599
    • Grozinsky-Glasberg, S.1    Fraser, A.2    Nahshoni, E.3    Weizman, A.4    Leibovici, L.5
  • 28
    • 84992400308 scopus 로고    scopus 로고
    • 3 therapy of hypothyroidism
    • 3 therapy of hypothyroidism. Eur. Thyroid J. 1, 129-131 (2012).
    • (2012) Eur. Thyroid J. , vol.1 , pp. 129-131
    • Ivkovic, S.1
  • 29
    • 84863583977 scopus 로고    scopus 로고
    • 3: Toward personalized replacement therapy in hypothyroidism?
    • 3: toward personalized replacement therapy in hypothyroidism? J. Clin. Endocrinol. Metab. 97, 2256-2271 (2012).
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 2256-2271
    • Biondi, B.1    Wartofsky, L.2
  • 30
    • 84868374724 scopus 로고    scopus 로고
    • Generation of functional thyroid from embryonic stem cells
    • Antonica, F. et al. Generation of functional thyroid from embryonic stem cells. Nature 491, 66-71 (2012).
    • (2012) Nature , vol.491 , pp. 66-71
    • Antonica, F.1
  • 31
    • 0036428317 scopus 로고    scopus 로고
    • Psychological wellbeing in patients
    • Ladenson, P. W. Psychological wellbeing in patients. Clin. Endocrinol. (Oxf.) 57, 575-576 (2002).
    • (2002) Clin. Endocrinol. (Oxf.) , vol.57 , pp. 575-576
    • Ladenson, P.W.1
  • 32
    • 0036426814 scopus 로고    scopus 로고
    • Psychological well-being in patients on 'adequate' doses of l-thyroxine: Results of a large, controlled community-based questionnaire study
    • Saravanan, P. et al. Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study. Clin. Endocrinol. (Oxf.) 57, 577-585 (2002).
    • (2002) Clin. Endocrinol. (Oxf.) , vol.57 , pp. 577-585
    • Saravanan, P.1
  • 33
    • 29644433344 scopus 로고    scopus 로고
    • Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism
    • Wekking, E. M. et al. Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur. J. Endocrinol. 153, 747-753 (2005).
    • (2005) Eur. J. Endocrinol. , vol.153 , pp. 747-753
    • Wekking, E.M.1
  • 34
    • 69949168737 scopus 로고    scopus 로고
    • 4: Findings from the HUNT study
    • 4: findings from the HUNT study. Clin. Endocrinol. (Oxf.) 71, 574-580 (2009).
    • (2009) Clin. Endocrinol. (Oxf.) , vol.71 , pp. 574-580
    • Panicker, V.1
  • 35
    • 34147189574 scopus 로고    scopus 로고
    • Health status, psychological symptoms, mood, and cognition in l-thyroxine-treated hypothyroid subjects
    • Samuels, M. H., Schuff, K. G., Carlson, N. E., Carello P. & Janowsky, J. S. Health status, psychological symptoms, mood, and cognition in l-thyroxine-treated hypothyroid subjects. Thyroid 17, 249-258 (2007).
    • (2007) Thyroid , vol.17 , pp. 249-258
    • Samuels, M.H.1    Schuff, K.G.2    Carlson, N.E.3    Carello, P.4    Janowsky, J.S.5
  • 36
    • 84876707338 scopus 로고    scopus 로고
    • Patient-reported outcomes in adequately treated hypothyroidism-insights from the German versions of ThyDQoL ThySRQ and ThyTSQ
    • Quinque, E. M., Villringer, A., Kratzsch, L. & Karger, S. Patient-reported outcomes in adequately treated hypothyroidism-insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ. Health Qual. Life Outcomes 11, 68 (2013).
    • (2013) Health Qual. Life Outcomes , vol.11 , pp. 68
    • Quinque, E.M.1    Villringer, A.2    Kratzsch, L.3    Karger, S.4
  • 37
    • 61449179292 scopus 로고    scopus 로고
    • Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder? Am
    • Somers, E. C., Thomas, S. L., Smeeth, L. & Hall, A. J. Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder? Am. J. Epidemiol. 169, 749-755 (2009).
    • (2009) J. Epidemiol. , vol.169 , pp. 749-755
    • Somers, E.C.1    Thomas, S.L.2    Smeeth, L.3    Hall, A.J.4
  • 38
    • 74549169972 scopus 로고    scopus 로고
    • Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease
    • Boelaert, K. et al. Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am. J. Med. 123, 183.e1-e9 (2010).
    • (2010) Am. J. Med. , vol.123 , pp. 183e1-183e9
    • Boelaert, K.1
  • 39
    • 79952364747 scopus 로고    scopus 로고
    • Diseases associated with thyroid autoimmunity: Explanations for the expanding spectrum
    • Weetman, A. P. Diseases associated with thyroid autoimmunity: explanations for the expanding spectrum. Clin. Endocrinol. (Oxf.) 74, 411-418 (2011).
    • (2011) Clin. Endocrinol. (Oxf.) , vol.74 , pp. 411-418
    • Weetman, A.P.1
  • 40
    • 27444436890 scopus 로고    scopus 로고
    • Thyroid autoimmunity, depression and anxiety: Are there any connections? An epidemiological study of a large population
    • Engum, A., Bjøro, T., Mykletun, A. & Dahl, A. A. Thyroid autoimmunity, depression and anxiety: are there any connections? An epidemiological study of a large population. J. Psychosom. Res. 59, 263-268 (2005).
    • (2005) J. Psychosom. Res. , vol.59 , pp. 263-268
    • Engum, A.1    Bjøro, T.2    Mykletun, A.3    Dahl, A.A.4
  • 41
    • 0031741263 scopus 로고    scopus 로고
    • Are autoimmune thyroid dysfunction and depression related?
    • Pop, V. J. et al. Are autoimmune thyroid dysfunction and depression related? J. Clin. Endocrinol. Metab. 83, 3194-3197 (1998).
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 3194-3197
    • Pop, V.J.1
  • 42
    • 84875748033 scopus 로고    scopus 로고
    • Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism? Eur
    • Watt, T. et al. Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism? Eur. Thyroid J. 1, 186-192 (2012).
    • (2012) Thyroid J. , vol.1 , pp. 186-192
    • Watt, T.1
  • 43
    • 79953234740 scopus 로고    scopus 로고
    • Hashimoto's thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: A prospective case-control study in women undergoing thyroidectomy for benign goiter
    • Ott, J. et al. Hashimoto's thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: a prospective case-control study in women undergoing thyroidectomy for benign goiter. Thyroid 21, 161-167 (2011).
    • (2011) Thyroid , vol.21 , pp. 161-167
    • Ott, J.1
  • 44
    • 33748754873 scopus 로고    scopus 로고
    • Psychological well-being correlates with free thyroxine but not free 3, 5, 3'-triiodothyronine levels in patients on thyroid hormone replacement
    • Saravanan, P., Visser, T. J. & Dayan, C. M. Psychological well-being correlates with free thyroxine but not free 3, 5, 3'-triiodothyronine levels in patients on thyroid hormone replacement. J. Clin. Endocrinol. Metab. 91, 3389-3393 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 3389-3393
    • Saravanan, P.1    Visser, T.J.2    Dayan, C.M.3
  • 45
    • 0023867084 scopus 로고
    • Fine adjustment of thyroxine replacement dosage: Comparison of the thyrotrophin releasing hormone test using a sensitive thyrotrophin assay with measurement of free thyroid hormones and clinical assessment
    • Carr, D., McLeod, D. T., Parry, G. & Thornes, H. M. Fine adjustment of thyroxine replacement dosage: comparison of the thyrotrophin releasing hormone test using a sensitive thyrotrophin assay with measurement of free thyroid hormones and clinical assessment. Clin. Endocrinol. (Oxf.) 28, 325-333 (1988).
    • (1988) Clin. Endocrinol. (Oxf.) , vol.28 , pp. 325-333
    • Carr, D.1    McLeod, D.T.2    Parry, G.3    Thornes, H.M.4
  • 46
    • 0037425789 scopus 로고    scopus 로고
    • Thyroid function tests and hypothyroidism. Measurement of serum TSH alone may not always reflect thyroid status
    • Toft, A. D. & Beckett, G. J. Thyroid function tests and hypothyroidism. Measurement of serum TSH alone may not always reflect thyroid status. BMJ 326, 295-296 (2003).
    • (2003) BMJ , vol.326 , pp. 295-296
    • Toft, A.D.1    Beckett, G.J.2
  • 47
    • 75149179019 scopus 로고    scopus 로고
    • Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy
    • Flynn, R. W. et al. Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. J. Clin. Endocrinol. Metab. 95, 186-193 (2010).
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 186-193
    • Flynn, R.W.1
  • 48
    • 33745770866 scopus 로고    scopus 로고
    • Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: Results of a double-blind, randomized clinical trial
    • Walsh, J. P. et al. Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: results of a double-blind, randomized clinical trial. J. Clin. Endocrinol. Metab. 91, 2624-2630 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 2624-2630
    • Walsh, J.P.1
  • 49
    • 0036123394 scopus 로고    scopus 로고
    • Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations
    • Woeber, K. A. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. J. Endocrinol. Invest. 25, 106-109 (2002).
    • (2002) J. Endocrinol. Invest. , vol.25 , pp. 106-109
    • Woeber, K.A.1
  • 50
    • 39549097301 scopus 로고    scopus 로고
    • Triiodothyronine levels in athyreotic individuals during levothyroxine therapy
    • Jonklaas, J., Davidson, B., Bhagat, S. & Soldin, S. J. Triiodothyronine levels in athyreotic individuals during levothyroxine therapy. JAMA 299, 769-777 (2008).
    • (2008) JAMA , vol.299 , pp. 769-777
    • Jonklaas, J.1    Davidson, B.2    Bhagat, S.3    Soldin, S.J.4
  • 51
    • 84865756960 scopus 로고    scopus 로고
    • TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy
    • Ito, M. et al. TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy. Eur. J. Endocrinol. 167, 373-378 (2012).
    • (2012) Eur. J. Endocrinol. , vol.167 , pp. 373-378
    • Ito, M.1
  • 52
    • 0023103073 scopus 로고
    • Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans
    • Fish, L. H. et al. Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans. N. Engl. J. Med. 316, 764-770 (1987).
    • (1987) N. Engl. J. Med. , vol.316 , pp. 764-770
    • Fish, L.H.1
  • 53
    • 79960953366 scopus 로고    scopus 로고
    • Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients
    • Gullo, D. et al. Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. PLoS ONE 6, e22552 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e22552
    • Gullo, D.1
  • 55
    • 84874510511 scopus 로고    scopus 로고
    • Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? Eur
    • Hoermann, R., Midgley, J. E., Larisch, R. & Dietrich, J. W. Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? Eur. J. Endocrinol. 168, 271-280 (2013).
    • (2013) J. Endocrinol. , vol.168 , pp. 271-280
    • Hoermann, R.1    Midgley, J.E.2    Larisch, R.3    Dietrich, J.W.4
  • 56
    • 57349119069 scopus 로고    scopus 로고
    • Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling
    • Gereben, B. et al. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr. Rev. 29, 898-938 (2008).
    • (2008) Endocr. Rev. , vol.29 , pp. 898-938
    • Gereben, B.1
  • 57
    • 84877576168 scopus 로고    scopus 로고
    • Thyroid hormone replacement therapy: Three 'simple' questions, complex answers
    • Bianco, A. C. & Casula, S. Thyroid hormone replacement therapy: three 'simple' questions, complex answers. Eur. Thyroid J. 1, 88-98 (2012).
    • (2012) Eur. Thyroid J. , vol.1 , pp. 88-98
    • Bianco, A.C.1    Casula, S.2
  • 60
    • 18844405937 scopus 로고    scopus 로고
    • Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: A double-blind, randomized, controlled clinical trial
    • Appelhof, B. C. et al. Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. J. Clin. Endocrinol. Metab. 90, 2666-2674 (2005).
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 2666-2674
    • Appelhof, B.C.1
  • 61
    • 10744221589 scopus 로고    scopus 로고
    • Combined thyroxine/liothyronine treatment does not improve well-being, quality of life or cognitive function compared to thyroxine alone: A randomized controlled trial in patients with primary hypothyroidism
    • Walsh, J. P. et al. Combined thyroxine/liothyronine treatment does not improve well-being, quality of life or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J. Clin. Endocrinol. Metab. 88, 4543-4550 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4543-4550
    • Walsh, J.P.1
  • 62
    • 0345060920 scopus 로고    scopus 로고
    • Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: A randomized controlled trial
    • Clyde, P. W., Harari, A. E., Getka, E. J. & Shakir, K. M. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. JAMA 290, 2952-2958 (2003).
    • (2003) JAMA , vol.290 , pp. 2952-2958
    • Clyde, P.W.1    Harari, A.E.2    Getka, E.J.3    Shakir, K.M.4
  • 64
    • 18744419707 scopus 로고    scopus 로고
    • Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism
    • Bunevicius, R., Kazanavicius, G., Zalinkevicius, R. & Prange, A. J. Jr. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N. Engl. J. Med. 340, 424-429 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 424-429
    • Bunevicius, R.1    Kazanavicius, G.2    Zalinkevicius, R.3    Prange, A.J.4
  • 65
    • 30444437570 scopus 로고    scopus 로고
    • Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: Effect on fatigue, symptoms of depression, and working memory versus treatment with thyroxine alone
    • Rodriguez, T., Lavis, V. R., Meininger, J. C., Kapadia, A.S & Stafford, L. F. Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with thyroxine alone. Endocr. Pract. 11, 223-233 (2005).
    • (2005) Endocr. Pract. , vol.11 , pp. 223-233
    • Rodriguez, T.1    Lavis, V.R.2    Meininger, J.C.3    Kapadia, A.S.4    Stafford, L.F.5
  • 66
    • 14844339782 scopus 로고    scopus 로고
    • Thyroid hormone replacement therapy in primary hypothyroidism: A randomized trial comparing l-thyroxine plus liothyronine with l-thyroxine alone
    • Escobar-Morreale, H. F. et al. Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing l-thyroxine plus liothyronine with l-thyroxine alone. Ann. Intern. Med. 142, 412-424 (2005).
    • (2005) Ann. Intern. Med. , vol.142 , pp. 412-424
    • Escobar-Morreale, H.F.1
  • 67
    • 2942716790 scopus 로고    scopus 로고
    • Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14:1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism
    • Siegmund, W. et al. Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14:1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism. Clin. Endocrinol. (Oxf.) 60, 750-757 (2004).
    • (2004) Clin. Endocrinol. (Oxf.) , vol.60 , pp. 750-757
    • Siegmund, W.1
  • 68
    • 0036658669 scopus 로고    scopus 로고
    • Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves' disease
    • Bunevicius, R., Jakubonien, N., Jurkevicius, R., Cernicat, J., Lasas, L. & Prange. A. J. Jr. Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves' disease. Endocrine 18, 129-133 (2002).
    • (2002) Endocrine , vol.18 , pp. 129-133
    • Bunevicius, R.1    Jakubonien, N.2    Jurkevicius, R.3    Cernicat, J.4    Lasas, L.5    Prange, A.J.6
  • 69
    • 68349113552 scopus 로고    scopus 로고
    • Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism
    • Ma, C. et al. Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism. Nucl. Med. Commun.30, 586-593 (2009).
    • (2009) Nucl. Med. Commun. , vol.30 , pp. 586-593
    • Ma, C.1
  • 72
    • 77956270879 scopus 로고    scopus 로고
    • Combined therapy with l-thyroxine and l-triiodothyronine compared to l-thyroxine alone in the treatment of primary hypothyroidism
    • Fadeyev, V. V., Morgunova, T. B., Melnichenko, G. A. & Dedov, I.I. Combined therapy with l-thyroxine and l-triiodothyronine compared to l-thyroxine alone in the treatment of primary hypothyroidism. Hormones (Athens) 9, 245-252 (2010).
    • (2010) Hormones (Athens) , vol.9 , pp. 245-252
    • Fadeyev, V.V.1    Morgunova, T.B.2    Melnichenko, G.A.3    Dedov, I.I.4
  • 73
    • 84877712177 scopus 로고    scopus 로고
    • Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study
    • Hoang, T. D., Olsen, C. H., Mai, V. Q., Clyde, P. W. & Shakir, M. K. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. J. Clin. Endocrinol. Metab. 98, 1982-1990 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 1982-1990
    • Hoang, T.D.1    Olsen, C.H.2    Mai, V.Q.3    Clyde, P.W.4    Shakir, M.K.5
  • 75
    • 72949123467 scopus 로고    scopus 로고
    • 3 combination therapy in hypothyroidism? Eur
    • 3 combination therapy in hypothyroidism? Eur. J. Endocrinol. 161, 955-959 (2009).
    • (2009) J. Endocrinol. , vol.161 , pp. 955-959
    • Wiersinga, W.M.1
  • 76
    • 0025366287 scopus 로고
    • Thyroidal and peripheral production of 3, 5, 3'-triiodothyronine in humans by multicompartmental analysis
    • Pilo, A. et al. Thyroidal and peripheral production of 3, 5, 3'-triiodothyronine in humans by multicompartmental analysis. Am. J. Physiol. 258 (Pt 1), E715-E726 (1990).
    • (1990) Am. J. Physiol. , vol.258 , pp. E715-E726
    • Pilo, A.1
  • 77
    • 67649373281 scopus 로고    scopus 로고
    • Novel insights into thyroid hormones from the study of common genetic variation
    • Dayan, C. M. & Panicker, V. Novel insights into thyroid hormones from the study of common genetic variation. Nat. Rev. Endocrinol. 5, 211-218 (2009).
    • (2009) Nat. Rev. Endocrinol. , vol.5 , pp. 211-218
    • Dayan, C.M.1    Panicker, V.2
  • 78
    • 84869026413 scopus 로고    scopus 로고
    • Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism
    • Louwerens, M. et al. Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism. Eur. J. Endocrinol. 167, 809-815 (2012).
    • (2012) Eur. J. Endocrinol. , vol.167 , pp. 809-815
    • Louwerens, M.1
  • 79
    • 44449164338 scopus 로고    scopus 로고
    • Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    • Arnaud-Lopez, L. et al. Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am. J. Hum. Genet. 82, 1270-1280 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 1270-1280
    • Arnaud-Lopez, L.1
  • 80
    • 70449096468 scopus 로고    scopus 로고
    • Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy
    • Shields, B. M. et al. Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. J. Clin. Endocrinol. Metab. 94, 4608-4612 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 4608-4612
    • Shields, B.M.1
  • 82
    • 79955530386 scopus 로고    scopus 로고
    • A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement
    • Taylor, P. N. et al. A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. Eur. J. Endocrinol. 164, 773-780 (2011).
    • (2011) Eur. J. Endocrinol. , vol.164 , pp. 773-780
    • Taylor, P.N.1
  • 83
    • 0037563907 scopus 로고    scopus 로고
    • Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects
    • Peeters, R. P. et al. Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects. J. Clin. Endocrinol. Metab. 88, 2880-2888 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2880-2888
    • Peeters, R.P.1
  • 84
    • 49249115232 scopus 로고    scopus 로고
    • A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and free triiodothyronine
    • Panicker, V. et al. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and free triiodothyronine. J. Clin. Endocrinol. Metab. 93, 3075-3081 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 3075-3081
    • Panicker, V.1
  • 85
    • 66149086542 scopus 로고    scopus 로고
    • The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: An investigation in healthy Danish twins
    • van der Deure, W. M. et al. The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins. Clin. Endocrinol. (Oxf.) 70, 954-960 (2009).
    • (2009) Clin. Endocrinol. (Oxf.) , vol.70 , pp. 954-960
    • Van Der Deure, W.M.1
  • 86
    • 66149144319 scopus 로고    scopus 로고
    • Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients
    • Panicker, V. et al. Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J. Clin. Endocrinol. Metab. 94, 1623-1629 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 1623-1629
    • Panicker, V.1
  • 87
    • 21044432096 scopus 로고    scopus 로고
    • A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    • Peeters, R. P. et al. A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. Am. J. Physiol. Endocrinol. Metab. 289, E75-E81 (2005).
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289 , pp. E75-E81
    • Peeters, R.P.1
  • 88
    • 40849083521 scopus 로고    scopus 로고
    • Type 2 deiodinase polymorphism (threonine 92 alanine) predicts l-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients
    • Torlontano, M. et al. Type 2 deiodinase polymorphism (threonine 92 alanine) predicts l-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients. J. Clin. Endocrinol. Metab. 93, 910-913 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 910-913
    • Torlontano, M.1
  • 89
    • 67650330260 scopus 로고    scopus 로고
    • 4 dose in athyroid patients or patients with Hashimoto thyroiditis
    • 4 dose in athyroid patients or patients with Hashimoto thyroiditis. Clin. Endocrinol. (Oxf.) 71, 279-283 (2009).
    • (2009) Clin. Endocrinol. (Oxf.) , vol.71 , pp. 279-283
    • Heemstra, K.A.1
  • 90
    • 66149125628 scopus 로고    scopus 로고
    • For some, l-thyroxine replacement might not be enough: A genetic rationale
    • Kim, B. W. & Bianco, A. C. For some, l-thyroxine replacement might not be enough: a genetic rationale. J. Clin. Endocrinol. Metab. 94, 1521-1523 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 1521-1523
    • Kim, B.W.1    Bianco, A.C.2
  • 91
    • 27744525730 scopus 로고    scopus 로고
    • Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3, 5, 3'-triiodothyronine therapy
    • Appelhof, B. C. et al. Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3, 5, 3'-triiodothyronine therapy. J. Clin. Endocrinol. Metab. 90, 6296-6299 (2005).
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 6296-6299
    • Appelhof, B.C.1
  • 92
    • 53549085312 scopus 로고    scopus 로고
    • Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients
    • van der Deure, W. M. et al. Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients. Clin. Endocrinol. (Oxf.) 69, 804-811 (2008).
    • (2008) Clin. Endocrinol. (Oxf.) , vol.69 , pp. 804-811
    • Van Der Deure, W.M.1
  • 93
    • 0345600946 scopus 로고    scopus 로고
    • 3 therapy-back to the drawing board
    • 3 therapy-back to the drawing board. JAMA 290, 3002-3004 (2003).
    • (2003) JAMA , vol.290 , pp. 3002-3004
    • Cooper, D.S.1
  • 94
    • 77950269479 scopus 로고    scopus 로고
    • The pharmacodynamic equivalence of levothyroxine and liothyronine: A randomized, double blind, cross-over study in thyroidectomized patients
    • Celi, F. S. et al. The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. Clin. Endocrinol. (Oxf.) 72, 709-715 (2010).
    • (2010) Clin. Endocrinol. (Oxf.) , vol.72 , pp. 709-715
    • Celi, F.S.1
  • 95
    • 80655145199 scopus 로고    scopus 로고
    • Metabolic effects of liothyronine therapy in hypothyroidism: A randomized, double-blind, crossover trial of liothyronine versus levothyroxine
    • Celi, F. S. et al. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J. Clin. Endocrinol. Metab. 96, 3466-3474 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 3466-3474
    • Celi, F.S.1
  • 96
    • 84877713272 scopus 로고    scopus 로고
    • The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy
    • Yavuz, S. et al. The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy. J. Clin. Endocrinol. Metab. 98, E862-E866 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. E862-E866
    • Yavuz, S.1
  • 97
    • 45149088434 scopus 로고    scopus 로고
    • Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels
    • Russell, W. et al. Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels. J. Clin. Endocrinol. Metab. 93, 2300-2306 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 2300-2306
    • Russell, W.1
  • 98
    • 2342519483 scopus 로고    scopus 로고
    • Thyroxine plus low-dose, slow-release triiodothyronine replacement in hypothyroidism: Proof of principle
    • Hennemann, G., Docter, R., Visser, T. J., Postema, P. T. & Krenning, E. P. Thyroxine plus low-dose, slow-release triiodothyronine replacement in hypothyroidism: proof of principle. Thyroid 14, 271-275 (2004).
    • (2004) Thyroid , vol.14 , pp. 271-275
    • Hennemann, G.1    Docter, R.2    Visser, T.J.3    Postema, P.T.4    Krenning, E.P.5
  • 99
    • 0242288751 scopus 로고    scopus 로고
    • In search of the impossible dream? Thyroid hormone replacement therapy that treats all symptoms in all hypothyroid patients
    • Kaplan, M. M., Sarne, D. H. & Schneider, A. B. In search of the impossible dream? Thyroid hormone replacement therapy that treats all symptoms in all hypothyroid patients. J. Clin. Endocrinol. Metab. 88, 4540-4542 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4540-4542
    • Kaplan, M.M.1    Sarne, D.H.2    Schneider, A.B.3


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