The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: An investigation in healthy Danish twins

Clinical Endocrinology

Volumn 70, Issue 6, 2009, Pages 954-960

  Visser, Theo J ^a   Van Der Deure, Wendy M ^a   Hansen, Pia Skov ^a,b,c   Peeters, Robin P ^a   Uitterlinden, André G ^a   Fenger, Mogens ^d   Kyvik, Kirsten Ohm ^c   Hegedüs, Laszlo ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d Mental Health Services CPH   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3,3',5' TRIIODOTHYRONINE; DEIODINASE 1; LIOTHYRONINE; MESSENGER RNA; PEROXIDASE; THYROXINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEIODINATION; ENZYME ACTIVITY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LIOTHYRONINE BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RNA DEGRADATION; THYROXINE BLOOD LEVEL; TWINS;

ADULT; CELL LINE; DENMARK; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; IODIDE PEROXIDASE; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; THYROID HORMONES; TWINS;

EID: 66149086542     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03420.x     Document Type: Article

References (23)

1. Bianco, A.C., Salvatore, D., Gereben, B. et al. (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Reviews, 23, 38 89. (Pubitemid 34185306)
2. Peeters, R.P., van Toor, H., Klootwijk, W. et al. (2003) Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects. Journal of Clinical Endocrinology and Metabolism, 88, 2880 2888. (Pubitemid 36724470)
3. Peeters, R.P., van der Deure, W.M. Visser, T.J. (2006) Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases. European Journal of Endocrinology, 155, 655 662.
4. de Jong, F.J., Peeters, R.P., den Heijer, T. et al. (2007) The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe. Journal of Clinical Endocrinology and Metabolism, 92, 636 640. (Pubitemid 46255308)
5. Peeters, R.P., van den Beld, A.W., Attalki, H. et al. (2005) A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. American Journal of Physiology. Endocrinology and Metabolism, 289, E75 E81.
6. Hansen, P.S., Brix, T.H., Sorensen, T.I. et al. (2004) Major genetic influence on the regulation of the pituitary-thyroid axis: A study of healthy Danish twins. Journal of Clinical Endocrinology and Metabolism, 89, 1181 1187. (Pubitemid 38368409)
7. Panicker, V., Wilson, S.G., Spector, T.D. et al. (2007) Heritability of serum TSH, free T4 and free T3 concentrations: A study of a large UK twin cohort. Clinical Endocrinology, 68, 652 659.
8. Hansen, P.S., van der Deure, W.M., Peeters, R.P. et al. (2007) The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population. Clinical Endocrinology, 66, 827 832. (Pubitemid 47024269)
9. Fang, Y., van Meurs, J.B., d'Alesio, A. et al. (2005) Promoter and 3′-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: The Rotterdam study. American Journal of Human Genetics, 77, 807 823. (Pubitemid 41513282)
10. Skytthe, A., Kyvik, K., Holm, N.V. et al. (2002) The Danish Twin Registry: 127 birth cohorts of twins. Twin Research, 5, 352 357. (Pubitemid 35315483)
11. Hansen, P.S., Brix, T.H., Bennedbaek, F.N. et al. (2004) Genetic and environmental causes of individual differences in thyroid size: A study of healthy Danish twins. Journal of Clinical Endocrinology and Metabolism, 89, 2071 2077. (Pubitemid 38619834)
12. Benyamin, B., Sorensen, T.I., Schousboe, K. et al. (2007) Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia, 50, 1880 1888. (Pubitemid 47222870)
13. Visser, T.J., Docter, R. Hennemann, G. (1977) Radioimmunoassay of reverse tri-iodothyronine. The Journal of Endocrinology, 73, 395 396.
14. Friesema, E.C., Kuiper, G.G., Jansen, J. et al. (2006) Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Molecular Endocrinology, 20, 2761 2772.
15. Peeters, R.P., Wouters, P.J., Kaptein, E. et al. (2003) Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. Journal of Clinical Endocrinology and Metabolism, 88, 3202 3211. (Pubitemid 36877495)
16. Stephens, M., Smith, N.J. Donnelly, P. (2001) A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics, 68, 978 989. (Pubitemid 32289743)
17. Neale, M.C. Maes, H.H. (2002) Methodology for Genetic Studies of Twins and Families. Kluwer Academic Publishers B.V., Dordrecht, The Netherlands.
18. Neale, M.C., Boker, S.M., Xie, G. et al. (2002) In MX: Statistical Modeling, 6th edn. Department of Psychiatry, Richmond, VA 23298.
19. Peeters, R.P., van den Beld, A.W., van Toor, H. et al. (2005) A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans. Journal of Clinical Endocrinology and Metabolism, 90, 256 263. (Pubitemid 40116666)
20. Peeters, R.P., Wouters, P.J., van Toor, H. et al. (2005) Serum 3,3′,5′-triiodothyronine (rT3) and 3,5,3′-triiodothyronine/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities. Journal of Clinical Endocrinology and Metabolism, 90, 4559 4565. (Pubitemid 41159343)
21. Panicker, V., Cluett, C., Shields, B. et al. (2008) A Common variation in Deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triidothyronine. Journal of Clinical Endocrinology and Metabolism, 93, 3075 3081.
22. Betel, D., Wilson, M., Gabow, A. et al. (2008) The microRNA.org resource: Targets and expression. Nucleic Acids Research, 36, D149 D153.
23. Georges, M., Coppieters, W. Charlier, C. (2007) Polymorphic miRNA-mediated gene regulation: Contribution to phenotypic variation and disease. Current Opinion in Genetics and Development, 17, 166 176. (Pubitemid 46843549)