메뉴 건너뛰기




Volumn 30, Issue 8, 2009, Pages 586-593

Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism

Author keywords

Hypothyroidism; Thyroxine; Triiodothyronine

Indexed keywords

LIOTHYRONINE; THYROID HORMONE; THYROTROPIN; THYROXINE;

EID: 68349113552     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32832c79e0     Document Type: Review
Times cited : (69)

References (32)
  • 1
    • 0037967164 scopus 로고    scopus 로고
    • Treatment for congenital hypothyroidism: Thyroxine alone or thyroxine plus triiodothyronine?
    • Cassio A, Cacciari E, Cicognani A, Damiani G, Missiroli G, et al. Treatment for congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine? Pediatrics 2003; 111 (5 Pt 1):1055-1060.
    • (2003) Pediatrics , vol.111 , Issue.5 PART 1 , pp. 1055-1060
    • Cassio, A.1    Cacciari, E.2    Cicognani, A.3    Damiani, G.4    Missiroli, G.5
  • 2
    • 18744419707 scopus 로고    scopus 로고
    • Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism
    • DOI 10.1056/NEJM199902113400603
    • Bunevicius R, Karanavicius G, Zalinkevicius R, Prange AJ Jr. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999; 340:424-429. (Pubitemid 29084773)
    • (1999) New England Journal of Medicine , vol.340 , Issue.6 , pp. 424-429
    • Bunevicius, R.1    Kazanavicius, G.2    Zalinkevicius, R.3    Prange Jr., A.J.4
  • 3
    • 0033920253 scopus 로고    scopus 로고
    • Mental improvement after replacement therapy with thyroxine plus triiodothyronine: Relationship to cause of hypothyroidism
    • DOI 10.1017/S1461145700001826
    • Bunevicius R, Prange AJ. Mental improvement after replacement therapy with thyroxine plus triiodothyronine: relationship to cause of hypothyroidism. Int J Neuropsychopharmacol 2000; 3:167-174. (Pubitemid 30429360)
    • (2000) International Journal of Neuropsychopharmacology , vol.3 , Issue.2 , pp. 167-174
    • Bunevicius, R.1    Prange Jr., A.J.2
  • 4
    • 0345060920 scopus 로고    scopus 로고
    • Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: A randomized controlled trial
    • Clyde PW, Harari AE, Getka EJ, Shakir KM. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. JAMA 2003; 290:2952-2958.
    • (2003) JAMA , vol.290 , pp. 2952-2958
    • Clyde, P.W.1    Harari, A.E.2    Getka, E.J.3    Shakir, K.M.4
  • 5
    • 14844339782 scopus 로고    scopus 로고
    • Thyroid hormone replacement therapy in primary hypothyroidism: A randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone
    • Escobar-Morreale HF, Botella-Carretero JI, Gómez-Bueno M, Galán JM, Barrios V, Sancho J, et al. Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med 2005; 142:412-424. (Pubitemid 40365429)
    • (2005) Annals of Internal Medicine , vol.142 , Issue.6
    • Escobar-Morreale, H.F.1    Botella-Carretero, J.I.2    Gomez-Bueno, M.3    Galan, J.M.4    Barrios, V.5    Sancho, J.6
  • 6
    • 30444437570 scopus 로고    scopus 로고
    • Substitution of liothyronine at a 1: 5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone
    • Rodriguez T, Lavis VR, Meininger JC, Kapadia AS, Stafford LF. Substitution of liothyronine at a 1 : 5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. Endocr Pract 2005; 11:223-233.
    • (2005) Endocr Pract , vol.11 , pp. 223-233
    • Rodriguez, T.1    Lavis, V.R.2    Meininger, J.C.3    Kapadia, A.S.4    Stafford, L.F.5
  • 7
    • 14044272888 scopus 로고    scopus 로고
    • Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: Results of a large community-based randomized controlled trial
    • Saravanan P, Simmons DJ, Greenwood R, Peters TJ, Dayan CM. Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial. J Clin Endocrinol Metab 2005; 90:805-812.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 805-812
    • Saravanan, P.1    Simmons, D.J.2    Greenwood, R.3    Peters, T.J.4    Dayan, C.M.5
  • 8
    • 2942716790 scopus 로고    scopus 로고
    • Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14:1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism
    • DOI 10.1111/j.1365-2265.2004.02050.x
    • Siegmund W, Spieker K, Weike AI, Giessmann T, Modess C, et al. Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism. Clin Endocrinol (Oxf) 2004; 60:750-757. (Pubitemid 38788084)
    • (2004) Clinical Endocrinology , vol.60 , Issue.6 , pp. 750-757
    • Siegmund, W.1    Spieker, K.2    Weike, A.I.3    Giessmann, T.4    Modess, C.5    Dabers, T.6    Kirsch, G.7    Sanger, E.8    Engel, G.9    Hamm, A.O.10    Nauck, M.11    Meng, W.12
  • 9
    • 0242288746 scopus 로고    scopus 로고
    • Does a combination regimen of thyroxine (T4) and 3,5,3′- triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial
    • Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT. Does a combination regimen of thyroxine (T4) and 3,5,3′-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 2003; 88:4551-4555.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4551-4555
    • Sawka, A.M.1    Gerstein, H.C.2    Marriott, M.J.3    MacQueen, G.M.4    Joffe, R.T.5
  • 10
    • 0014953297 scopus 로고
    • Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism
    • Smith RN, Taylor SA, Massey JC. Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism. Br Med J 1970; 4:145-148.
    • (1970) Br Med J , vol.4 , pp. 145-148
    • Smith, R.N.1    Taylor, S.A.2    Massey, J.C.3
  • 12
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21:1539-1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.T.1    Thompson, S.G.2
  • 15
    • 34548291456 scopus 로고    scopus 로고
    • Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: A literature review and metaanalysis
    • DOI 10.1176/appi.psy.48.5.379
    • Joffe RT, Brimacombe M, Levitt AJ, Stagnaro-Green A. Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: a literature review and meta analysis. Psychosomatics 2007; 48:379-384. (Pubitemid 47330290)
    • (2007) Psychosomatics , vol.48 , Issue.5 , pp. 379-384
    • Joffe, R.T.1    Brimacombe, M.2    Levitt, A.J.3    Stagnaro-Green, A.4
  • 16
    • 0017650132 scopus 로고
    • Pituitary nuclear 3,5,3- Triiodothyronine and thyrotropin secretion: An explanation for the effect of thyroxine
    • Silva JE, Larsen PR. Pituitary nuclear 3,5,3- triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science 1977; 198:617-620.
    • (1977) Science , vol.198 , pp. 617-620
    • Silva, J.E.1    Larsen, P.R.2
  • 17
    • 0019754949 scopus 로고
    • Relationships between circulating and intracellular thyroid hormones: Physiological and clinical implications
    • Larsen PR, Silva JE, Kaplan MM. Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev 1981; 2:87-102.
    • (1981) Endocr Rev , vol.2 , pp. 87-102
    • Larsen, P.R.1    Silva, J.E.2    Kaplan, M.M.3
  • 18
    • 0020470739 scopus 로고
    • Comparison of iodothyronine 5′-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism
    • Silva JE, Larsen PR. Comparison of iodothyronine 5′-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism. J Clin Invest 1982; 70:1110-1123.
    • (1982) J Clin Invest , vol.70 , pp. 1110-1123
    • Silva, J.E.1    Larsen, P.R.2
  • 19
    • 0028861989 scopus 로고
    • Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats
    • Escobar-Morreale HF, Obrego'n MJ, Escobar del Rey FE, Morreale de Escobar G. Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. J Clin Invest 1995; 96:2828-2838.
    • (1995) J Clin Invest , vol.96 , pp. 2828-2838
    • Escobar-Morreale, H.F.1    Obrego'N, M.J.2    Escobar Del Rey, F.E.3    De Morreale Escobar, G.4
  • 20
    • 0029938145 scopus 로고    scopus 로고
    • Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat
    • Escobar-Morreale HF, Escobar del Rey FE, Obrego'n MJ, de Escobar GM. Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology 1996; 137:2490-2502.
    • (1996) Endocrinology , vol.137 , pp. 2490-2502
    • Escobar-Morreale, H.F.1    Escobar Del Rey, F.E.2    Obrego'N, M.J.3    De Escobar, G.M.4
  • 22
    • 0025366287 scopus 로고
    • Thyroidal and peripheral production of 3,5,3′-triiodothyronine in humans by multicompartmental analysis
    • Pilo A, Iervasi G, Vitek F, Ferdeghini M, Cazzuola F, Bianchi R. Thyroidal and peripheral production of 3,5,3′-triiodothyronine in humans by multicompartmental analysis. Am J Physiol 1990; 258 (4 Pt 1):E715-E726.
    • (1990) Am J Physiol , vol.258 , Issue.4 PART 1
    • Pilo, A.1    Iervasi, G.2    Vitek, F.3    Ferdeghini, M.4    Cazzuola, F.5    Bianchi, R.6
  • 23
    • 0036905980 scopus 로고    scopus 로고
    • Dissatisfaction with thyroxine therapy: Could the patients be right?
    • Walsh JP. Dissatisfaction with thyroxine therapy: could the patients be right? Curr Opin Pharmacol 2002; 2:717-722.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 717-722
    • Walsh, J.P.1
  • 24
    • 0242288751 scopus 로고    scopus 로고
    • In search of the impossible dream? Thyroid hormone replacement therapy that treats all symptoms in all hypothyroid patients
    • Kaplan MM, Sarne DH, Schneider AB. In search of the impossible dream? Thyroid hormone replacement therapy that treats all symptoms in all hypothyroid patients. J Clin Endocrinol Metab 2003; 88:4540-4542.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4540-4542
    • Kaplan, M.M.1    Sarne, D.H.2    Schneider, A.B.3
  • 25
    • 0022576606 scopus 로고
    • Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration
    • Brent GA, Hershman JM. Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. J Clin Endocrinol Metab 1986; 63:1-8.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1-8
    • Brent, G.A.1    Hershman, J.M.2
  • 26
    • 0024995158 scopus 로고
    • Thyroxine, 3,5,3′-triiodothyronine, and 3,3′,5′- triiodothyronine concentrations in several tissues of the rat: Effects of amiodarone and desethylamiodarone on thyroid hormone metabolism
    • Schröder-van der Elst JP, van der Heide D. Thyroxine, 3,5,3′-triiodothyronine, and 3,3′,5′-triiodothyronine concentrations in several tissues of the rat: effects of amiodarone and desethylamiodarone on thyroid hormone metabolism. Endocrinology 1990; 127:1656-1664.
    • (1990) Endocrinology , vol.127 , pp. 1656-1664
    • Schröder-van Der Elst, J.P.1    Van Der Heide, D.2
  • 27
    • 0015459801 scopus 로고
    • A new radioimmunoassay for plasma L-triiodothyronine: Measurements in thyroid disease and in patients maintained on hormonal replacement
    • Surks MI, Schadlow AR, Oppenheimer JH. A new radioimmunoassay for plasma L-triiodothyronine: measurements in thyroid disease and in patients maintained on hormonal replacement. J Clin Invest 1972; 5:3104-3113.
    • (1972) J Clin Invest , vol.5 , pp. 3104-3113
    • Surks, M.I.1    Schadlow, A.R.2    Oppenheimer, J.H.3
  • 29
    • 0345600946 scopus 로고    scopus 로고
    • 3 Therapy - Back to the Drawing Board
    • DOI 10.1001/jama.290.22.3002
    • Cooper DS. Combined T4 and triiodothyronine therapy - back to the drawing board. JAMA 2003; 290:3002-3004. (Pubitemid 37505535)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.22 , pp. 3002-3004
    • Cooper, D.S.1
  • 30
    • 2342519483 scopus 로고    scopus 로고
    • Thyroxine Plus Low-Dose, Slow-Release Triiodothyronine Replacement in Hypothyroidism: Proof of Principle
    • DOI 10.1089/105072504323030924
    • Hennemann G, Docter R, Visser TJ, Postema PT, Krenning EP. Thyroxine plus low-dose, slow-release triiodothyronine replacement in hypothyroidism: proof of principle. Thyroid 2004; 14:271-275. (Pubitemid 38569276)
    • (2004) Thyroid , vol.14 , Issue.4 , pp. 271-275
    • Hennemann, G.1    Docter, R.2    Visser, T.J.3    Postema, P.T.4    Krenning, E.P.5
  • 31
    • 2342456501 scopus 로고    scopus 로고
    • Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: Are we a step closer to the magic formula?
    • Wartofsky L. Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: are we a step closer to the magic formula? Thyroid 2004; 14:247-248.
    • (2004) Thyroid , vol.14 , pp. 247-248
    • Wartofsky, L.1
  • 32
    • 34248582561 scopus 로고    scopus 로고
    • Twenty-four hour hormone profiles of TSH, Free triiodothyronine and free T4 in hypothyroid patients on combined triiodothyronine/T4 therapy
    • Saravanan P, Siddique H, Simmons DJ, Greenwood R, Dayan CM. Twenty-four hour hormone profiles of TSH, Free triiodothyronine and free T4 in hypothyroid patients on combined triiodothyronine/T4 therapy. Exp Clin Endocrinol Diabetes 2007; 115:261-267.
    • (2007) Exp Clin Endocrinol Diabetes , vol.115 , pp. 261-267
    • Saravanan, P.1    Siddique, H.2    Simmons, D.J.3    Greenwood, R.4    Dayan, C.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.