Psychotherapy for PTSD: Neuroimaging of Recovery Processes

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 26, Issue 3, 2014, Pages 188-195

  Erickson, Heidi J ^a   Hurley, Robin A ^a,b,c   Taber, Katherine ^a,c,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLOOD OXYGENATION; BRAIN BLOOD FLOW; BRAIN SIZE; CINGULATE GYRUS; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; GRAY MATTER; HUMAN; LONGITUDINAL STUDY; META ANALYSIS; MONOZYGOTIC TWINS; NEAR INFRARED SPECTROSCOPY; PERSONAL EXPERIENCE; POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOTHERAPY; RISK FACTOR; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VENTROMEDIAL PREFRONTAL CORTEX; BRAIN; CONVALESCENCE; NEUROIMAGING; PATHOLOGY; PHYSIOLOGY; PROCEDURES; STRESS DISORDERS, POST-TRAUMATIC; VASCULARIZATION;

BRAIN; HUMANS; NEUROIMAGING; PSYCHOTHERAPY; RECOVERY OF FUNCTION; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84905709060     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.260301     Document Type: Article

References (76)

1. Hayes JP, Hayes SM, Mikedis AM: Quantitative meta-analysis of neural activity in posttraumatic stress disorder. Biol Mood Anxiety Disord 2012; 2:9
2. Sartory G, Cwik J, Knuppertz H, et al: In search of the trauma memory: a meta-analysis of functional neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD). PLoS ONE 2013; 8:e58150
3. Pagani M, Högberg G, Salmaso D, et al: Effects of EMDR psychotherapy on 99mTc-HMPAO distribution in occupationrelated post-traumatic stress disorder. NuclMed Commun 2007; 28:757-765
4. Peres JF, Newberg AB, Mercante JP, et al: Cerebral blood flow changes during retrieval of traumatic memories before and after psychotherapy: a SPECT study. PsycholMed 2007; 37:1481-1491
5. Lindauer RJL, Booij J, Habraken JBA, et al: Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial. Psychol Med 2008; 38:543-554
6. Steenkamp MM, Litz BT: Psychotherapy for military-related posttraumatic stress disorder: review of the evidence. Clin Psychol Rev 2013; 33:45-53
7. Rauch SL, Shin LM, Phelps EA: Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol Psychiatry 2006; 60:376-382
8. Holmes A, Singewald N: Individual differences in recovery from traumatic fear. Trends Neurosci 2013; 36:23-31
9. Marek R, Strobel C, Bredy TW, et al: The amygdala and medial prefrontal cortex: partners in the fear circuit. J Physiol 2013; 591:2381-2391
10. Maren S, Phan KL, Liberzon I: The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 2013; 14:417-428
11. Pitman RK, Rasmusson AM, Koenen KC, et al: Biological studies of post-traumatic stress disorder. Nat Rev Neurosci 2012; 13:769-787
12. Shin LM, Handwerger K: Is posttraumatic stress disorder a stress-induced fear circuitry disorder? J Trauma Stress 2009; 22:409-415
13. Shin LM, Liberzon I: The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 2010; 35:169-191
14. Etkin A, Wager TD: Functional neuroimaging of anxiety: a metaanalysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 2007; 164:1476-1488
15. Patel R, Spreng RN, Shin LM, et al: Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev 2012; 36:2130-2142
16. Simmons AN, Matthews SC: Neural circuitry of PTSD with or without mild traumatic brain injury: a meta-analysis. Neuropharmacology 2012; 62:598-606
17. Morey RA, Petty CM, Cooper DA, et al: Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans. Psychiatry Res 2008; 162:59-72
18. Hayes JP, LaBar KS, McCarthy G, et al: VISN 6 Mid-Atlantic MIRECC workgroup: Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD. J Psychiatr Res 2011; 45: 660-669
19. Chao LL, Lenoci M, Neylan TC: Effects of post-traumatic stress disorder on occipital lobe function and structure. Neuroreport 2012; 23:412-419
20. Herringa RJ, Phillips ML, Fournier JC, et al: Childhood and adult trauma both correlate with dorsal anterior cingulate activation to threat in combat veterans. Psychol Med 2013; 43:1533-1542
21. Simmons AN, Flagan TM, Wittmann M, et al: The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD. J Affect Disord 2013; 146:426-432
22. Rabinak CA, Macnamara A, Kennedy AE, et al: Focal and aberrant prefrontal engagement during emotion regulation in veterans with posttraumatic stress disorder. Depress Anxiety (Epub ahead of print, Feb 22, 2014)
23. Shin LM, Bush G, Milad MR, et al: Exaggerated activation of dorsal anterior cingulate cortex during cognitive interference: a monozygotic twin study of posttraumatic stress disorder. Am J Psychiatry 2011; 168:979-985
24. Daniels JK, Coupland NJ, Hegadoren KM, et al: Neural and behavioral correlates of peritraumatic dissociation in an acutely traumatized sample. J Clin Psychiatry 2012; 73:420-426
25. Bourne C, Mackay CE, Holmes EA: The neural basis of flashback formation: the impact of viewing trauma. Psychol Med 2013; 43:1521-1532
26. Whalley MG, Kroes MC, Huntley Z, et al: An fMRI investigation of posttraumatic flashbacks. Brain Cogn 2013; 81:151-159
27. Lanius RA, Brand B, Vermetten E, et al: The dissociative subtype of posttraumatic stress disorder: rationale, clinical and neurobiological evidence, and implications. Depress Anxiety 2012; 29:701-708
28. Wolf EJ, Lunney CA, Miller MW, et al: The dissociative subtype of PTSD: a replication and extension. Depress Anxiety 2012; 29:679-688
29. Weston CS: Posttraumatic stress disorder: a theoretical model of the hyperarousal subtype. Front Psychiatry 2014; 5:37
30. Daniels JK, McFarlane AC, Bluhm RL, et al: Switching between executive and default mode networks in posttraumatic stress disorder: alterations in functional connectivity. J Psychiatry Neurosci 2010; 35:258-266
31. Sripada RK, King AP, Welsh RC, et al: Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks. Psychosom Med 2012; 74:904-911
32. Chen AC, Etkin A: Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder. Neuropsychopharmacology 2013; 38:1889-1898
33. Brown VM, LaBar KS, Haswell CC, et al: Mid-Atlantic MIRECC Workgroup: Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder. Neuropsychopharmacology 2014; 39:351-359
34. Hedges DW, Woon FL: Premorbid brain volume estimates and reduced total brain volume in adults exposed to trauma with or without posttraumatic stress disorder: a meta-analysis. Cogn Behav Neurol 2010; 23:124-129
35. Hart H, Rubia K: Neuroimaging of child abuse: a critical review. Front Hum Neurosci 2012; 6:52
36. Rinne-Albers MA, van der Wee NJ, Lamers-Winkelman F, et al: Neuroimaging in children, adolescents and young adults with psychological trauma. Eur Child Adolesc Psychiatry 2013; 22:745-755
37. Cardenas VA, Samuelson K, Lenoci M, et al: Changes in brain anatomy during the course of posttraumatic stress disorder. Psychiatry Res 2011; 193:93-100
38. Shucard JL, Cox J, Shucard DW, et al: Symptoms of posttraumatic stress disorder and exposure to traumatic stressors are related to brain structural volumes and behavioral measures of affective stimulus processing in police officers. Psychiatry Res 2012; 204:25-31
39. Childress JE, McDowell EJ, Dalai VV, et al: Hippocampal volumes in patients with chronic combat-related posttraumatic stress disorder: a systematic review. J Neuropsychiatry Clin Neurosci 2013; 25:12-25
40. Woon FL, Sood S, Hedges DW: Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34:1181-1188
41. Chao LL, Yaffe K, Samuelson K, et al: Hippocampal volume is inversely related to PTSD duration. Psychiatry Res 2014; 222:119-123
42. Kühn S, Gallinat J: Gray matter correlates of posttraumatic stress disorder: a quantitative meta-analysis. Biol Psychiatry 2013; 73:70-74
43. Li L, Wu M, Liao Y, et al: Grey matter reduction associated with posttraumatic stress disorder and traumatic stress. Neurosci Biobehav Rev 2014; 43C:163-172
44. Morey RA, Gold AL, LaBar KS, et al: Mid-Atlantic MIRECC Workgroup: Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group. Arch Gen Psychiatry 2012; 69:1169-1178
45. Herringa R, Phillips M, Almeida J, et al.: Post-traumatic stress symptoms correlate with smaller subgenual cingulate, caudate, and insula volumes in unmedicated combat veterans. Psychiatry Res 2012; 203:139-145
46. Rocha-Rego V, Pereira MG, Oliveira L, et al: Decreased premotor cortex volume in victims of urban violence with posttraumatic stress disorder. PLoS ONE 2012; 7:e42560
47. Starcevic A, Postic S, Radojicic Z, et al: Volumetric analysis of amygdala, hippocampus, and prefrontal cortex in therapynaive PTSD participants. Biomed Res Int (Epub ahead of print, March 13, 2014)
48. Gilbertson MW, Shenton ME, Ciszewski A, et al: Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 2002; 5:1242-1247
49. Kremen WS, Koenen KC, Afari N, et al: Twin studies of posttraumatic stress disorder: differentiating vulnerability factors from sequelae. Neuropharmacology 2012; 62:647-653
50. Chao L, Weiner M, Neylan T: Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Res 2013; 213:193-201
51. Admon R, Leykin D, Lubin G, et al: Stress-induced reduction in hippocampal volume and connectivity with the ventromedial prefrontal cortex are related to maladaptive responses to stressful military service. Hum Brain Mapp 2013; 34:2808-2816
52. Meng Y, Qiu C, Zhu H, et al: Anatomical deficits in adult posttraumatic stress disorder: A meta-analysis of voxel-based morphometry studies. Behav Brain Res 2014; 270C:307-315
53. Kuo JR, Kaloupek DG, Woodward SH: Amygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: a cross-sectional study. Arch Gen Psychiatry 2012; 69:1080-1086
54. Lindemer ER, Salat DH, Leritz EC, et al: Reduced cortical thickness with increased lifetime burden of PTSD in OEF/OIF Veterans and the impact of comorbid TBI. Neuroimage Clin 2013; 2:601-611
55. Corbo V, Salat DH, Amick MM, et al: Reduced cortical thickness in veterans exposed to early life trauma. Psychiatry Res (Epub ahead of print, May 2, 2014)
56. Kasai K, Yamasue H, Gilbertson MW, et al: Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biol Psychiatry 2008; 63:550-556
57. Kroes MC, Whalley MG, Rugg MD, et al: Association between flashbacks and structural brain abnormalities in posttraumatic stress disorder. Eur Psychiatry 2011; 26:525-531
58. Tavanti M, Battaglini M, Borgogni F, et al: Evidence of diffuse damage in frontal and occipital cortex in the brain of patients with post-traumatic stress disorder. Neurol Sci 2012; 33:59-68
59. Nardo D, Högberg G, Lanius RA, et al: Gray matter volume alterations related to trait dissociation in PTSD and traumatized controls. Acta Psychiatr Scand 2013; 128:222-233
60. Thomaes K, Dorrepaal E, Draijer N, et al: Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD. J Clin Psychiatry 2010; 71:1636-1644
61. Weber M, Killgore WD, Rosso IM, et al: Voxel-based morphometric gray matter correlates of posttraumatic stress disorder. J Anxiety Disord 2013; 27:413-419
62. Rabe S, Zoellner T, Beauducel A, et al: Changes in brain electrical activity after cognitive behavioral therapy for posttraumatic stress disorder in patients injured in motor vehicle accidents. Psychosom Med 2008; 70:13-19
63. Pagani M, Di Lorenzo G, Verardo AR, et al: Neurobiological correlates of EMDR monitoring-an EEG study. PLoS ONE 2012; 7:e45753
64. Ohtani T, Matsuo K, Kasai K, et al: Hemodynamic responses of eye movement desensitization and reprocessing in posttraumatic stress disorder. Neurosci Res 2009; 65:375-383
65. Peres JF, Foerster B, Santana LG, et al: Police officers under attack: resilience implications of an fMRI study. J Psychiatr Res 2011; 45:727-734
66. Dickie EW, Brunet A, Akerib V, et al: Neural correlates of recovery from post-traumatic stress disorder: a longitudinal fMRI investigation of memory encoding. Neuropsychologia 2011; 49:1771-1778
67. Farrow TF, Hunter MD, Wilkinson ID, et al: Quantifiable change in functional brain response to empathic and forgivability judgments with resolution of posttraumatic stress disorder. Psychiatry Res 2005; 140:45-53
68. Lansing K, Amen DG, Hanks C, et al: High-resolution brain SPECT imaging and eye movement desensitization and reprocessing in police officers with PTSD. J Neuropsychiatry Clin Neurosci 2005; 17:526-532
69. Felmingham K, Kemp A, Williams L, et al: Changes in anterior cingulate and amygdala after cognitive behavior therapy of posttraumatic stress disorder. Psychol Sci 2007; 18:127-129
70. Roy MJ, Francis J, Friedlander J, et al: Improvement in cerebral function with treatment of posttraumatic stress disorder. Ann N Y Acad Sci 2010; 1208:142-149
71. Thomaes K, Dorrepaal E, Draijer N, et al: Treatment effects on insular and anterior cingulate cortex activation during classic and emotional Stroop interference in child abuse-related complex post-traumatic stress disorder. Psychol Med 2012; 42:2337-2349
72. Roy MJ, Costanzo ME, Blair JR, et al: Compelling evidence that exposure therapy for PTSD normalizes brain function. Stud Health Technol Inform 2014; 199:61-65
73. Lindauer RJ, Vlieger EJ, Jalink M, et al: Effects of psychotherapy on hippocampal volume in out-patients with posttraumatic stress disorder: a MRI investigation. Psychol Med 2005; 35:1421-1431
74. Bossini L, Tavanti M, Calossi S, et al: EMDR treatment for posttraumatic stress disorder, with focus on hippocampal volumes: a pilot study. J Neuropsychiatry Clin Neurosci 2011; 23:E1-E2
75. Levy-Gigi E, Szabó C, Kelemen O, et al: Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy. Biol Psychiatry 2013; 74:793-800
76. Dichter GS, Sikich L, Song A, et al: Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations. Int J Neurosci 2012; 122: 483-493