Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD

Journal of Clinical Psychiatry

Volumn 71, Issue 12, 2010, Pages 1636-1644

  Thomaes, Kathleen ^a   Dorrepaal, Ethy ^a   Draijer, Nel ^a   De Ruiter, Michiel B ^a   Van Balkom, Anton J ^a   Smit, Johannes H ^a   Veltman, Dick J ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOLISM; ANGER; ANTERIOR CINGULATE; ANXIETY DISORDER; ARTICLE; BORDERLINE STATE; BRAIN SIZE; CHILD ABUSE; CHILD SEXUAL ABUSE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT TOOL; COMORBIDITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; DISEASE SEVERITY; EATING DISORDER; FEMALE; GRAY MATTER; HIPPOCAMPUS; HUMAN; IMPULSIVENESS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBITAL CORTEX; PERSONALITY DISORDER; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; STRUCTURED CLINICAL INTERVIEW FOR DISORDERS OF EXTREME STRESS; SUPPLEMENTARY MOTOR AREA; VOXEL BASED MORPHOMETRY;

ADULT; ANGER; BORDERLINE PERSONALITY DISORDER; CASE-CONTROL STUDIES; CEREBRAL CORTEX; CHILD; CHILD ABUSE; COMORBIDITY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FRONTAL LOBE; FUNCTIONAL LATERALITY; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMPULSIVE BEHAVIOR; MAGNETIC RESONANCE IMAGING; PERSONALITY DISORDERS; SEVERITY OF ILLNESS INDEX; STRESS DISORDERS, POST-TRAUMATIC;

EID: 78650508989     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.08m04754blu     Document Type: Article

References (101)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington DC: American Psychiatric Association; 2000.
2. Herman JL. Complex PTSD: a syndrome in survivors of prolonged and repeated trauma. J Trauma Stress. 2006;5(3):377-391.
3. van der Kolk BA, Pelcovitz D, Roth S, et al. Dissociation, somatization, and affect dysregulation: the complexity of adaptation of trauma. Am J Psychiatry. 1996;153(suppl):83-93.
4. Zlotnick C, Zakriski AL, Shea MT, et al. The long-term sequelae of sexual abuse: support for a complex posttraumatic stress disorder. J Trauma Stress. 1996;9(2):195-205.
5. Breslau N. Outcomes of posttraumatic stress disorder. J Clin Psychiatry. 2001;62(suppl 17):55-59.
6. Ford JD, Stockton P, Kaltman S, et al. Disorders of extreme stress (DESNOS) symptoms are associated with type and severity of interpersonal trauma exposure in a sample of healthy young women. J Interpers Violence. 2006;21(11):1399-1416.
7. Green BL, Goodman LA, Krupnick JL, et al. Outcomes of single versus multiple trauma exposure in a screening sample. J Trauma Stress. 2000;13(2):271-286.
8. Terr LC. Childhood traumas: an outline and overview. Am J Psychiatry. 1991;148(1):10-20.
9. Kessler RC, Sonnega A, Bromet E, et al. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52(12):1048-1060.
10. McGlashan TH, Grilo CM, Skodol AE, et al. The Collaborative Longitudinal Personality Disorders Study: baseline Axis I/II and II/II diagnostic co-occurrence. Acta Psychiatr Scand. 2000;102(4):256-264.
11. Sar V, Akyüz G, Doǧan O. Prevalence of dissociative disorders among women in the general population. Psychiatry Res. 2007;149(1-3):169-176. (Pubitemid 46127579)
12. Höing M, van Engen A, Ensink B, et al. Hulp aan slachtoffers van seksueel geweld: een inventarisatie en kwaliteitsevaluatie van de behandeling van slachtoffers van seksueel geweld in de GGZ en de vrouwenopvang in Nederland. Delft, The Netherlands: Eburon; 2003.
13. Draijer N. Sexual Traumatization in Childhood. Long-Term Impact of Sexual Abuse of Girls. Amsterdam, the Netherlands: SUA; 1990.
14. Breslau N, Kessler RC, Chilcoat HD, et al. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. Arch Gen Psychiatry. 1998;55(7):626-632.
15. Elzinga BM, Bremner JD. Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)? J Affect Disord. 2002;70(1):1-17.
16. Sapolsky RM. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry. 2000;57(10):925-935.
17. Karl A, Schaefer M, Malta LS, et al. A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev. 2006;30(7):1004-1031.
18. Fennema-Notestine C, Stein MB, Kennedy CM, et al. Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder. Biol Psychiatry. 2002;52(11):1089-1101.
19. Jatzko A, Rothenhöfer S, Schmitt A, et al. Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods. J Affect Disord. 2006;94(1-3):121-126.
20. Pederson CL, Maurer SH, Kaminski PL, et al. Hippocampal volume and memory performance in a community-based sample of women with posttraumatic stress disorder secondary to child abuse. J Trauma Stress. 2004;17(1):37-40.
21. Winter H, Irle E. Hippocampal volume in adult burn patients with and without posttraumatic stress disorder. Am J Psychiatry. 2004;161(12):2194-2200. (Pubitemid 39587283)
22. De Bellis MD, Keshavan MS, Shifflett H, et al. Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry. 2002;52(11):1066-1078.
23. Bonne O, Brandes D, Gilboa A, et al. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am J Psychiatry. 2001;158(8):1248-1251.
24. Freeman T, Kimbrell T, Booe L, et al. Evidence of resilience: neuroimaging in former prisoners of war. Psychiatry Res. 2006;146(1):59-64.
25. Golier JA, Yehuda R, De Santi S, et al. Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder. Psychiatry Res. 2005;139(1):53-64.
26. Yehuda R, Golier JA, Tischler L, et al. Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: relation to risk and resilience factors. J Psychiatr Res. 2007;41(5):435-445.
27. Rolls ET, Kesner RP. A computational theory of hippocampal function, and empirical tests of the theory. Prog Neurobiol. 2006;79(1):1-48.
28. Chen S, Xia W, Li L, et al. Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: a voxel-based morphometric study. Psychiatry Res. 2006;146(1):65-72.
29. Corbo V, Clément MH, Armony JL, et al. Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biol Psychiatry. 2005;58(2):119-124.
30. Kasai K, Yamasue H, Gilbertson MW, et al. Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biol Psychiatry. 2008;63(6):550-556.
31. Kitayama N, Quinn S, Bremner JD. Smaller volume of anterior cingulate cortex in abuse-related posttraumatic stress disorder. J Affect Disord. 2006;90(2-3):171-174.
32. Yamasue H, Kasai K, Iwanami A, et al. Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proc Natl Acad Sci U S A. 2003;100(15):9039-9043.
33. Rauch SL, Shin LM, Segal E, et al. Selectively reduced regional cortical volumes in post-traumatic stress disorder. Neuroreport. 2003;14(7):913-916.
34. Woodward SH, Kaloupek DG, Streeter CC, et al. Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry. 2006;59(7):582-587.
35. Rauch SL, Shin LM, Phelps EA. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol Psychiatry. 2006;60(4):376-382.
36. Francati V, Vermetten E, Bremner JD. Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings. Depress Anxiety. 2007;24(3):202-218.
37. Lanius RA, Williamson PC, Boksman K, et al. Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation. Biol Psychiatry. 2002;52(4):305-311.
38. Shin LM, Bush G, Whalen PJ, et al. Dorsal anterior cingulate function in posttraumatic stress disorder. J Trauma Stress. 2007;20(5):701-712.
39. 11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry. 2001;158(5):775-782.
40. Oquendo MA, Krunic A, Parsey RV, et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder. Neuropsychopharmacology. 2005;30(6):1163-1172.
41. Silbersweig D, Clarkin JF, Goldstein M, et al. Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. Am J Psychiatry. 2007;164(12):1832-1841.
42. Sapolsky RM. Stress, Glucocorticoids, and Damage to the nervous system: the current state of confusion. Stress. 1996;1(1):1-19.
43. Vermetten E, Vythilingam M, Southwick SM, et al. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry. 2003;54(7):693-702.
44. Gilbertson MW, Shenton ME, Ciszewski A, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002;5(11):1242-1247.
45. Clancy CP, Graybeal A, Tompson WP, et al. Lifetime trauma exposure in veterans with military-related posttraumatic stress disorder: association with current symptomatology. J Clin Psychiatry. 2006;67(9):1346-1353.
46. Weisbart CE, Thompson R, Pelaez-Merrick M, et al. Child and adult victimization: sequelae for female caregivers of high-risk children. Child Maltreat. 2008;13(3):235-244.
47. Heim C, Newport DJ, Wagner D, et al. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety. 2002;15(3):117-125.
48. Teicher MH, Tomoda A, Andersen SL. Neurobiological consequences of early stress and childhood maltreatment: are results from human and animal studies comparable? Ann N Y Acad Sci. 2006;1071:313-323.
49. Bonne O, Vythilingam M, Inagaki M, et al. Reduced posterior hippocampal volume in posttraumatic stress disorder. J Clin Psychiatry. 2008;69(7):1087- 1091.
50. Draijer N. Structured Trauma Interview. Amsterdam, the Netherlands: Free University, Department of Psychiatry; 1989.
51. Blake DD, Weathers FW, Nagy LM, et al. The development of a clinician-administered PTSD Scale. J Trauma Stress. 1995;8(1):75-90.
52. Hovens JE, van der Ploeg HM, Klaarenbeek MT, et al. The assessment of posttraumatic stress disorder: with the Clinician Administered PTSD Scale: Dutch results. J Clin Psychol. 1994;50(3):325-340.
53. First MB, Spitzer RL, Williams JBW, et al. Structured Clinical Interview for DSM-IV Diagnoses (SCID-I). Washington, DC: American Psychiatric Association; 1995.
54. Pfohl B, Blum N, Zimmerman M. Structured Interview for DSM-IV Personality (SIDP-IV). Washington, DC: American Psychiatric Press, Inc; 1997.
55. Beck AT, Steer RA, Garbin MG. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev. 1988;8(1):77-100.
56. Bernstein EM, Putnam FW. Development, reliability, and validity of a dissociation scale. J Nerv Ment Dis. 1986;174(12):727-735.
57. Arntz A, van den Hoorn M, Cornelis J, et al. Reliability and validity of the borderline personality disorder severity index. J Pers Disord. 2003;17(1):45-59.
58. Derogatis LR, Lipman RS, Covi L. SCL-90: an outpatient psychiatric rating scale-preliminary report. Psychopharmacol Bull. 1973;9(1):13-28.
59. Steinberg M, Rounsaville B, Cicchetti DV. The Structured Clinical Interview for DSM-III-R Dissociative Disorders: preliminary report on a new diagnostic instrument. Am J Psychiatry. 1990;147(1):76-82.
60. Ashburner J, Friston KJ. Voxel-based morphometry: the methods. Neuroimage. 2000;11(6 pt 1):805-821.
61. Ashburner J, Friston KJ. Why voxel-based morphometry should be used. Neuroimage. 2001;14(6):1238-1243.
62. Putnam FW, Carlson EB, Ross CA, et al. Patterns of dissociation in clinical and nonclinical samples. J Nerv Ment Dis. 1996;184(11):673-679.
63. Van Ijzendoorn MH, Schuengel C. The measurement of dissociation in normal and clinical populations: meta analytic validation of the dissociative experiences scale (DES). Clin Psychol Rev. 1996;16(5):365-382.
64. Bremner JD, Randall P, Vermetten E, et al. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: a preliminary report. Biol Psychiatry. 1997;41(1):23-32. (Pubitemid 27050642)
65. Bremner JD, Vythilingam M, Vermetten E, et al. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. Am J Psychiatry. 2003;160(5):924-932.
66. Stein MB, Koverola C, Hanna C, et al. Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med. 1997;27(4):951-959. (Pubitemid 27332181)
67. Hakamata Y, Matsuoka Y, Inagaki M, et al. Structure of orbitofrontal cortex and its longitudinal course in cancer-related post-traumatic stress disorder. Neurosci Res. 2007;59(4):383-389.
68. Lacerda AL, Keshavan MS, Hardan AY, et al. Anatomic evaluation of the orbitofrontal cortex in major depressive disorder. Biol Psychiatry. 2004;55(4):353-358.
69. Chanen AM, Velakoulis D, Carison K, et al. Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Res. 2008;163(2):116-125.
70. Tebartz van Elst L, Hesslinger B, Thiel T, et al. Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biol Psychiatry. 2003;54(2):163-171.
71. Soloff PH, Meltzer CC, Becker C, et al. Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Res. 2003;123(3):153-163.
72. Milad MR, Rauch SL. The role of the orbitofrontal cortex in anxiety disorders. Ann N Y Acad Sci 2007;1121(Dec):546-561.
73. Veltman DJ, de Ruiter MB, Rombouts SA, et al. Neurophysiological correlates of increased verbal working memory in high-dissociative participants: a functional MRI study. Psychol Med. 2005;35(2):175-185.
74. Clark CR, McFarlane AC, Morris P, et al. Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study. Biol Psychiatry. 2003;53(6):474-481.
75. Moores KA, Clark CR, McFarlane AC, et al. Abnormal recruitment of working memory updating networks during maintenance of traumaneutral information in post-traumatic stress disorder. Psychiatry Res. 2008;163(2):156-170.
76. Elzinga BM, Ardon AM, Heijnis MK, et al. Neural correlates of enhanced working-memory performance in dissociative disorder: a functional MRI study. Psychol Med. 2007;37(2):235-245.
77. Cloitre M, Stovall-McClough KC, Miranda R, et al. Therapeutic alliance, negative mood regulation, and treatment outcome in child abuse-related posttraumatic stress disorder. J Consult Clin Psychol. 2004;72(3):411-416. (Pubitemid 38679639)
78. Feeny NC, Zoellner LA, Foa EB. Treatment outcome for chronic PTSD among female assault victims with borderline personality characteristics: a preliminary examination. J Pers Disord. 2002;16(1):30-40.
79. Foa EB. Psychosocial treatment of posttraumatic stress disorder. J Clin Psychiatry. 2000;61(suppl 5):43-48, discussion 49-51.
80. Orth U, Cahill SP, Foa EB, et al. Anger and posttraumatic stress disorder symptoms in crime victims: a longitudinal analysis. J Consult Clin Psychol. 2008;76(2):208-218.
81. Zanarini MC, Frankenburg FR, Reich DB, et al. The subsyndromal phenomenology of borderline personality disorder: a 10-year follow-up study. Am J Psychiatry. 2007;164(6):929-935.
82. Cloitre M, Koenen KC. The impact of borderline personality disorder on process group outcome among women with posttraumatic stress disorder related to childhood abuse. Int J Group Psychother. 2001;51(3):379-398.
83. Lau M, Kristensen E. Outcome of systemic and analytic group psychotherapy for adult women with history of intrafamilial childhood sexual abuse: a randomized controlled study. Acta Psychiatr Scand. 2007;116(2):96-104. (Pubitemid 47076286)
84. Miller MW, Fogler JM, Wolf EJ, et al. The internalizing and externalizing structure of psychiatric comorbidity in combat veterans. J Trauma Stress. 2008;21(1):58-65.
85. Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry. 2004;161(11):1957-1966.
86. Vythilingam M, Heim C, Newport J, et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry. 2002;159(12):2072-2080.
87. Ehling T, Nijenhuis ER, Krikke AP. Volume of discrete brain structures in complex dissociative disorders: preliminary findings. Prog Brain Res. 2008;167:307-310.
88. Vermetten E, Schmahl C, Lindner S, et al. Hippocampal and amygdalar volumes in dissociative identity disorder. Am J Psychiatry. 2006;163(4):630-636.
89. Weniger G, Lange C, Sachsse U, et al. Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders. Acta Psychiatr Scand. 2008;118(4):281-290.
90. Brambilla P, Soloff PH, Sala M, et al. Anatomical MRI study of borderline personality disorder patients. Psychiatry Res. 2004;131(2):125-133. (Pubitemid 39094646)
91. Driessen M, Herrmann J, Stahl K, et al. Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Arch Gen Psychiatry. 2000;57(12):1115-1122.
92. Irle E, Lange C, Sachsse U. Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder. Biol Psychiatry. 2005;57(2):173-182.
93. Zetzsche T, Preuss UW, Frodl T, et al. Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorder. Psychiatry Res. 2007;154(2):157-170.
94. Yucel K, McKinnon MC, Chahal R, et al. Anterior cingulate volumes in never-treated patients with major depressive disorder. Neuropsychopharmacology. 2008;33(13):3157-3163.
95. Hazlett EA, New AS, Newmark R, et al. Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biol Psychiatry. 2005;58(8):614-623.
96. Hamilton JP, Siemer M, Gotlib IH. Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Mol Psychiatry. 2008;13(11):993-1000.
97. Rüsch N, van Elst LT, Ludaescher P, et al. A voxel-based morphometric MRI study in female patients with borderline personality disorder. Neuroimage. 2003;20(1):385-392. (Pubitemid 37188526)
98. Tebartz van Elst L, Ludaescher P, Thiel T, et al. Evidence of disturbed amygdalar energy metabolism in patients with borderline personality disorder. Neurosci Lett. 2007;417(1):36-41.
99. Zetzsche T, Frodl T, Preuss UW, et al. Amygdala volume and depressive symptoms in patients with borderline personality disorder. Biol Psychiatry. 2006;60(3):302-310.
100. Wright IC, Ellison ZR, Sharma T, et al. Mapping of grey matter changes in schizophrenia. Schizophr Res. 1999;35(1):1-14.
101. Davatzikos C. Why voxel-based morphometric analysis should be used with great caution when characterizing group differences. Neuroimage. 2004;23(1):17-20.