Neural circuitry of PTSD with or without mild traumatic brain injury: A meta-analysis

Neuropharmacology

Volumn 62, Issue 2, 2012, Pages 598-606

  Simmons, Alan N ^a,b,c   Matthews, Scott C ^a,b,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Center of Excellence in Stress and Mental Health   (United States)

^d Education and Clinical Center   (United States)

Author keywords

Amygdala; Brain imaging; Brain injury; Combat; Comorbid; Concussion; Dorsolateral frontal cortex; fMRI; Head injury; Insula; Loss of consciousness; Meta analysis; Middle frontal cortex; Military; Prefrontal cortex; PTSD; Review; TBI; Trauma

Indexed keywords

AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; BRAIN FUNCTION; BRAIN REGION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MIDDLE FRONTAL GYRUS; NEUROANATOMY; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY;

AFGHAN CAMPAIGN 2001-; BRAIN; BRAIN INJURIES; HUMANS; IRAQ WAR, 2003 -; LIFE CHANGE EVENTS; MILITARY PERSONNEL; NERVE NET; STRESS DISORDERS, POST-TRAUMATIC; VETERANS;

EID: 84855929217     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.03.016     Document Type: Review

References (120)

1. J.H. Adams Diffuse axonal injury in non-missile head injury Injury 13 5 1982 444 445
2. R.L. Amdur, and I. Liberzon The structure of posttraumatic stress disorder symptoms in combat veterans: a confirmatory factor analysis of the impact of event scale Journal of Anxiety Disorders 15 4 2001 345 357
3. American Psychiatric Association American Psychiatric Association. Task Force on DSM-IV. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR fourth ed. 2000 American Psychiatric Association Washington, DC
4. T.A. Ashman, L.A. Spielman, M.R. Hibbard, J.M. Silver, T. Chandna, and W.A. Gordon Psychiatric challenges in the first 6 years after traumatic brain injury: cross-sequential analyses of axis I disorders Archives of Physical Medicine and Rehabilitation 85 4 Suppl. 2 2004 S36 S42
5. R.S. Astur, S.A. St Germain, D. Tolin, J. Ford, D. Russell, and M. Stevens Hippocampus function predicts severity of post-traumatic stress disorder Cyberpsychology and Behavior 9 2 2006 234 240
6. P. Berryhill, M.A. Lilly, H.S. Levin, G.R. Hillman, D. Mendelsohn, and D.G. Brunder Frontal lobe changes after severe diffuse closed head injury in children: a volumetric study of magnetic resonance imaging Neurosurgery 37 3 1995 392 399 discussion 9-400
7. E.D. Bigler Neurobiology and neuropathology underlie the neuropsychological deficits associated with traumatic brain injury Archives of Clinical Neuropsychology 18 6 2003 595 621 discussion 3-7
8. C.H. Bombardier, J.R. Fann, N.R. Temkin, P.C. Esselman, J. Barber, and S.S. Dikmen Rates of major depressive disorder and clinical outcomes following traumatic brain injury Journal of the American Medical Association 303 19 2010 1938 1945
9. O. Bonne, M. Vythilingam, M. Inagaki, S. Wood, A. Neumeister, and A.C. Nugent Reduced posterior hippocampal volume in posttraumatic stress disorder Journal of Clinical Psychiatry 69 7 2008 1087 1091
10. J.A. Boscarino Posttraumatic stress disorder and mortality among U.S. army veterans 30 years after military service Annals of Epidemiology 16 4 2006 248 256
11. J.D. Bremner, J. Licinio, A. Darnell, J.H. Krystal, M.J. Owens, and S.M. Southwick Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder The American Journal of Psychiatry 154 5 1997 624 629
12. J.D. Bremner, M. Vythilingam, G. Anderson, E. Vermetten, T. McGlashan, and G. Heninger Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder Biological Psychiatry 54 7 2003 710 718
13. N. Breslau, and G.C. Davis Posttraumatic stress disorder: the etiologic specificity of wartime stressors The American Journal of Psychiatry 144 5 1987 578 583
14. N. Breslau, B.A. Reboussin, J.C. Anthony, and C.L. Storr The structure of posttraumatic stress disorder: latent class analysis in 2 community samples Archives of General Psychiatry 62 12 2005 1343 1351
15. N. Breslau The epidemiology of posttraumatic stress disorder: what is the extent of the problem? Journal of Clinical Psychiatry 62 Suppl. 17 2001 16 22
16. M. Brett The MNI Brain and The Talairach Atlas 1999 Available from: http://www.mrc-cbu.cam.ac.uk/Imaging/Common/mnispace.shtml
17. R.A. Bryant, K.L. Felmingham, A.H. Kemp, M. Barton, A.S. Peduto, and C. Rennie Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study Biological Psychiatry 58 2 2005 111 118
18. R.A. Bryant, A.H. Kemp, K.L. Felmingham, B. Liddell, G. Olivieri, and A. Peduto Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: an fMRI study Human Brain Mapping 29 5 2008 517 523
19. K.F. Carlson, D. Nelson, R.J. Orazem, S. Nugent, D.X. Cifu, and N.A. Sayer Psychiatric diagnoses among Iraq and Afghanistan war veterans screened for deployment-related traumatic brain injury Journal of Traumatic Stress 23 1 2010 17 24
20. V.G. Carrion, A. Garrett, V. Menon, C.F. Weems, and A.L. Reiss Posttraumatic stress symptoms and brain function during a response-inhibition task: an fMRI study in youth Depression and Anxiety 25 6 2008 514 526
21. I. Cernak, Z. Wang, J. Jiang, X. Bian, and J. Savic Ultrastructural and functional characteristics of blast injury-induced neurotrauma The Journal of Trauma 50 4 2001 695 706
22. J.K. Chen, K.M. Johnston, A. Collie, P. McCrory, and A. Ptito A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI Journal of Neurology, Neurosurgery, and Psychiatry 78 11 2007 1231 1238
23. S. Chen, L. Li, B. Xu, and J. Liu Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder BMC Psychiatry 9 2009 39
24. C. Christodoulou, J. DeLuca, J.H. Ricker, N.K. Madigan, B.M. Bly, and G. Lange Functional magnetic resonance imaging of working memory impairment after traumatic brain injury Journal of Neurology, Neurosurgery, and Psychiatry 71 2 2001 161 168
25. A.D. Craig How do you feel? Interoception: the sense of the physiological condition of the body Nature Reviews Neuroscience 3 8 2002 655 666
26. D.S. DeWitt, and D.S. Prough Blast-induced brain injury and posttraumatic hypotension and hypoxemia Journal of Neurotrauma 26 6 2009 877 887
27. I. Elman, S. Lowen, B.B. Frederick, W. Chi, L. Becerra, and R.K. Pitman Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder Biological Psychiatry 66 12 2009 1083 1090
28. A. Etkin, and T.D. Wager Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia The American Journal of Psychiatry 164 10 2007 1476 1488
29. CDC Facts About Traumatic Brain Injury Available from: http://www.cdc.gov/ncipc/tbi/FactSheets/TBI-Fact-Sheets.htm 2011
30. E. Falconer, R. Bryant, K.L. Felmingham, A.H. Kemp, E. Gordon, and A. Peduto The neural networks of inhibitory control in posttraumatic stress disorder Journal of Psychiatry and Neuroscience 33 5 2008 413 422
31. K.L. Felmingham, L.M. Williams, A.H. Kemp, C. Rennie, E. Gordon, and R.A. Bryant Anterior cingulate activity to salient stimuli is modulated by autonomic arousal in posttraumatic stress disorder Psychiatry Research 173 1 2009 59 62
32. E.B. Foa, D.S. Riggs, and B.S. Gershuny Arousal, numbing, and intrusion: symptom structure of PTSD following assault The American Journal of Psychiatry 152 1 1995 116 120
33. N. Frasure-Smith, F. Lesperance, and M. Talajic The impact of negative emotions on prognosis following myocardial infarction: is it more than depression? Health Psychology 14 5 1995 388 398
34. P. Frewen, R.D. Lane, R.W. Neufeld, M. Densmore, T. Stevens, and R. Lanius Neural correlates of levels of emotional awareness during trauma script-imagery in posttraumatic stress disorder Psychosomatic Medicine 70 1 2008 27 31
35. A.D. Gean Imaging of Head Trauma 1994 Raven Press New York
36. C.R. Genovese, N.A. Lazar, and T. Nichols Thresholding of statistical maps in functional neuroimaging using the false discovery rate NeuroImage 15 2002 870 878
37. T.D. Geracioti Jr., L.L. Carpenter, M.J. Owens, D.G. Baker, N.N. Ekhator, and P.S. Horn Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression The American Journal of Psychiatry 163 4 2006 637 643
38. E. Geuze, E. Vermetten, M. Ruf, C.S. de Kloet, and H.G. Westenberg Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder Journal of Psychiatratry Research 42 8 2008 659 669
39. E. Geuze, H.G. Westenberg, A. Jochims, C.S. de Kloet, M. Bohus, and E. Vermetten Altered pain processing in veterans with posttraumatic stress disorder Archives of General Psychiatry 64 1 2007 76 85
40. D.P. Graham, and A.L. Cardon An update on substance use and treatment following traumatic brain injury Annals of the New York Academy of Sciences 1141 2008 148 162
41. S.W. Hoffman, and C. Harrison The interaction between psychological health and traumatic brain injury: a neuroscience perspective The Clinical Neuropsychologist 23 8 2009 1400 1415
42. C.W. Hoge, J.L. Auchterlonie, and C.S. Milliken Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan Journal of the American Medical Association 295 9 2006 1023 1032
43. C.W. Hoge, D. McGurk, J.L. Thomas, A.L. Cox, C.C. Engel, and C.A. Castro Mild traumatic brain injury in U.S. soldiers returning from Iraq The New England Journal of Medicine 358 5 2008 453 463
44. L. Holm, J.D. Cassidy, L.J. Carroll, and J. Borg Summary of the WHO collaborating centre for neurotrauma task force on mild traumatic brain injury Journal of Rehabilitation Medicine 37 3 2005 137 141
45. T. Holsinger, D.C. Steffens, C. Phillips, M.J. Helms, R.J. Havlik, and J.C. Breitner Head injury in early adulthood and the lifetime risk of depression Archives of General Psychiatry 59 1 2002 17 22
46. R. Holtzer, R.G. Burright, S.J. Lynn, and P.J. Donovick Behavioural differences between psychiatric patients with confirmed versus non-confirmed traumatic brain injuries Brain Injury 14 11 2000 959 973
47. J.W. Hopper, P.A. Frewen, B.A. van der Kolk, and R.A. Lanius Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery Journal of Traumatic Stress 20 5 2007 713 725
48. C. Hou, J. Liu, K. Wang, L. Li, M. Liang, and Z. He Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD Brain Research 1144 2007 165 174
49. A. Jatzko, A. Schmitt, T. Demirakca, E. Weimer, and D.F. Braus Disturbance in the neural circuitry underlying positive emotional processing in post-traumatic stress disorder (PTSD). An fMRI study European Archives of Psychiatry and Clinical Neuroscience 256 2 2006 112 114
50. G.B. Kaplan, J.J. Vasterling, and P.C. Vedak Brain-derived neurotrophic factor in traumatic brain injury, post-traumatic stress disorder, and their comorbid conditions: role in pathogenesis and treatment Behavioural Pharmacology 21 5-6 2010 427 437
51. A.H. Kemp, K. Felmingham, P. Das, G. Hughes, A.S. Peduto, and R.A. Bryant Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study Psychiatry Research 155 3 2007 265 269
52. M.J. Kim, J. Chey, A. Chung, S. Bae, H. Khang, and B. Ham Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder Journal of Psychiatric Research 42 4 2008 268 277
53. P. Kochunov, J. Lancaster, P. Thompson, A.W. Toga, P. Brewer, and J. Hardies An optimized individual target brain in the Talairach coordinate system NeuroImage 17 2 2002 922 927
54. S. Koponen, T. Taiminen, R. Portin, L. Himanen, H. Isoniemi, and H. Heinonen Axis I and II psychiatric disorders after traumatic brain injury: a 30-year follow-up study The American Journal of Psychiatry 159 8 2002 1315 1321
55. R.A. Kulka, W.E. Schlenger, J.A. Fairbank, R.L. Hough, B.K. Jordan, and C.R. Marmar The National Vietnam Veterans Readjustment Study: Tables of Findings and Technical Appendices 1990 Brunner/Mazel New York
56. A.R. Laird, P.M. Fox, C.J. Price, D.C. Glahn, A.M. Uecker, and J.L. Lancaster ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts Human Brain Mapping 25 1 2005 155 164
57. R.A. Lanius, P.C. Williamson, M. Densmore, K. Boksman, M.A. Gupta, and R.W. Neufeld Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation The American Journal of Psychiatry 158 11 2001 1920 1922
58. R.A. Lanius, P.C. Williamson, K. Boksman, M. Densmore, M. Gupta, and R.W. Neufeld Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation Biological Psychiatry 52 4 2002 305 311
59. R.A. Lanius, P.C. Williamson, J. Hopper, M. Densmore, K. Boksman, and M.A. Gupta Recall of emotional states in posttraumatic stress disorder: an fMRI investigation Biological Psychiatry 53 3 2003 204 210
60. R.A. Lanius, P.A. Frewen, M. Girotti, R.W. Neufeld, T.K. Stevens, and M. Densmore Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigation Psychiatry Research 155 1 2007 45 56
61. J.E. LeDoux, P. Cicchetti, A. Xagoraris, and L.M. Romanski The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning Journal of Neuroscience 10 4 1990 1062 1069
62. K.Y. Lee, M.K. Nyein, D.F. Moore, J.D. Joannopoulos, S. Socrate, T. Imholt, R. Radovitzky, and S.G. Johnson Blast-induced electromagnetic fields in the brain from bone piezoelectricity Neuroimage 54 Suppl 1 2011 S30 S36
63. I. Liberzon, and C.S. Sripada The functional neuroanatomy of PTSD: a critical review Progress in Brain Research 167 2008 151 169
64. I. Liberzon, J.L. Abelson, S.B. Flagel, J. Raz, and E.A. Young Neuroendocrine and psychophysiologic responses in PTSD: a symptom provocation study Neuropsychopharmacology 21 1 1999 40 50
65. C.H. Lie, K. Specht, J.C. Marshall, and G.R. Fink Using fMRI to decompose the neural processes underlying the Wisconsin card sorting test NeuroImage 30 3 2006 1038 1049
66. J.B. Long, T.L. Bentley, K.A. Wessner, C. Cerone, S. Sweeney, and R.A. Bauman Blast overpressure in rats: recreating a battlefield injury in the laboratory Journal of Neurotrauma 26 6 2009 827 840
67. S.C. Matthews, I.A. Strigo, A.N. Simmons, R.M. O'Connell, L.E. Reinhardt, and S.A. Moseley A multimodal imaging study in U.S. veterans of operations Iraqi and enduring freedom with and without major depression after blast-related concussion NeuroImage 54 Suppl 1 2011 S69 S75
68. S.C. Matthews, A.N. Simmons, and I.A. Strigo The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion Psychiatry Research:Neuroimaging 191 1 2011 76 79
69. T.W. McAllister, M.B. Sparling, L.A. Flashman, S.J. Guerin, A.C. Mamourian, and A.J. Saykin Differential working memory load effects after mild traumatic brain injury NeuroImage 14 5 2001 1004 1012
70. L.M. McGuire, R.G. Burright, R. Williams, and P.J. Donovick Prevalence of traumatic brain injury in psychiatric and non-psychiatric subjects Brain Injury 12 3 1998 207 214
71. M.R. Milad, R.K. Pitman, C.B. Ellis, A.L. Gold, L.M. Shin, N.B. Lasko, M.A. Zeidan, K. Handwerger, S.P. Orr, and S.L. Rauch Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder Biological Psychiatry 66 12 2009 1075 1082
72. S. Mineka, and R. Zinbarg A contemporary learning theory perspective on the etiology of anxiety disorders: it's not what you thought it was The American Psychologist 61 1 2006 10 26
73. W. Mittenberg, and S. Strauman Diagnosis of mild head injury and the postconcussion syndrome The Journal of Head Trauma Rehabilitation 15 2 2000 783 791
74. J. Moll, R. de Oliveira-Souza, F.T. Moll, I.E. Bramati, and P.A. Andreiuolo The cerebral correlates of set-shifting: an fMRI study of the trail making test Arquivos de neuro-psiquiatria 60 4 2002 900 905
75. R.F. Mollica, I.K. Lyoo, M.C. Chernoff, H.X. Bui, J. Lavelle, and S.J. Yoon Brain structural abnormalities and mental health sequelae in South Vietnamese ex-political detainees who survived traumatic head injury and torture Archives of General Psychiatry 66 11 2009 1221 1232
76. D.F. Moore, A. Jerusalem, M. Nyein, L. Noels, M.S. Jaffee, and R.A. Radovitzky Computational biology - modeling of primary blast effects on the central nervous system NeuroImage 47 Suppl. 2 2009 T10 T20
77. L.M. Najavits, S.B. Norman, D. Kivlahan, and T.R. Kosten Improving PTSD/substance abuse treatment in the VA: a survey of providers The American Journal on Addictions 19 3 2010 257 263
78. C.B. Nemeroff, J.D. Bremner, E.B. Foa, H.S. Mayberg, C.S. North, and M.B. Stein Posttraumatic stress disorder: a state-of-the-science review Journal of Psychiatric Research 40 1 2006 1 21
79. A.S. New, J. Fan, J.W. Murrough, X. Liu, R.E. Liebman, and K.G. Guise A functional magnetic resonance imaging study of deliberate emotion regulation in resilience and posttraumatic stress disorder Biological Psychiatry 66 7 2009 656 664
80. C.S. North, S.J. Nixon, S. Shariat, S. Mallonee, J.C. McMillen, and E.L. Spitznagel Psychiatric disorders among survivors of the Oklahoma City bombing Journal of the American Medical Association 282 8 1999 755 762
81. J.T. Povlishock, and T.H. Coburn Morphopathological Change Associated with Mild Head Injury 1989 Oxford University Press New York
82. J.T. Povlishock, and D.I. Katz Update of neuropathology and neurological recovery after traumatic brain injury The Journal of Head Trauma Rehabilitation 20 1 2005 76 94
83. G.P. Prigatano, S.C. Johnson, and S.D. Gale Neuroimaging correlates of the Halstead finger tapping test several years post-traumatic brain injury Brain Injury 18 7 2004 661 669
84. H.G. Prigerson, P.K. Maciejewski, and R.A. Rosenheck Combat trauma: trauma with highest risk of delayed onset and unresolved posttraumatic stress disorder symptoms, unemployment, and abuse among men The Journal of Nervous and Mental Disease 189 2 2001 99 108
85. X. Protopopescu, H. Pan, O. Tuescher, M. Cloitre, M. Goldstein, and W. Engelien Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects Biological Psychiatry 57 5 2005 464 473
86. S.I. Rapaport, A. Zivelin, R.A. Minow, C.S. Hunter, and K. Donnelly Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin American Journal of Clinical Pathology 97 1 1992 84 91
87. S.L. Rauch, P.J. Whalen, L.M. Shin, S.C. McInerney, M.L. Macklin, and N.B. Lasko Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study Biological Psychiatry 47 9 2000 769 776
88. S.L. Rauch, L.M. Shin, and E.A. Phelps Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future Biological Psychiatry 60 4 2006 376 382
89. B.O. Rothbaum, and M. Davis Applying learning principles to the treatment of post-trauma reactions Annals of the New York Academy of Sciences 1008 2003 112 121
90. U. Sailer, S. Robinson, F.P. Fischmeister, D. Konig, C. Oppenauer, and B. Lueger-Schuster Altered reward processing in the nucleus accumbens and mesial prefrontal cortex of patients with posttraumatic stress disorder Neuropsychologia 46 11 2008 2836 2844
91. H. Sakamoto, R. Fukuda, T. Okuaki, M. Rogers, K. Kasai, and T. Machida Parahippocampal activation evoked by masked traumatic images in posttraumatic stress disorder: a functional MRI study NeuroImage 26 3 2005 813 821
92. N.A. Sayer, N.A. Rettmann, K.F. Carlson, N. Bernardy, B.J. Sigford, and J.L. Hamblen Veterans with history of mild traumatic brain injury and posttraumatic stress disorder: challenges from provider perspective Journal of Rehabilitation Research and Development 46 6 2009 703 716
93. M.E. Shaw, K.A. Moores, R.C. Clark, A.C. McFarlane, S.C. Strother, and R.A. Bryant Functional connectivity reveals inefficient working memory systems in post-traumatic stress disorder Psychiatry Research 172 3 2009 235 241
94. L.M. Shin, P.J. Whalen, R.K. Pitman, G. Bush, M.L. Macklin, and N.B. Lasko An fMRI study of anterior cingulate function in posttraumatic stress disorder Biological Psychiatry 50 12 2001 932 942
95. L.M. Shin, C.I. Wright, P.A. Cannistraro, M.M. Wedig, K. McMullin, and B. Martis A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder Archives of General Psychiatry 62 3 2005 273 281
96. L.M. Shin, S.L. Rauch, and R.K. Pitman Amygdala, medial prefrontal cortex, and hippocampal function in PTSD Annals of the New York Academy of Sciences 1071 2006 67 79
97. M. Sierra, and G.E. Berrios Depersonalization: neurobiological perspectives Biological Psychiatry 44 9 1998 898 908
98. A.N. Simmons, M.P. Paulus, S.R. Thorp, S.C. Matthews, S.B. Norman, and M.B. Stein Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence Biological Psychiatry 64 8 2008 681 690
99. A. Simmons, I.A. Strigo, S.C. Matthews, M.P. Paulus, and M.B. Stein Initial evidence of a failure to activate right anterior insula during affective set shifting in posttraumatic stress disorder Psychosomatic Medicine 71 4 2009 373 377
100. M. Staudt, W. Grodd, C. Gerloff, M. Erb, J. Stitz, and I. Krageloh-Mann Two types of ipsilateral reorganization in congenital hemiparesis: a TMS and fMRI study Brain 125 Pt 10 2002 2222 2237
101. M.B. Stein, and T.W. McAllister Exploring the convergence of posttraumatic stress disorder and mild traumatic brain injury The American Journal of Psychiatry 166 7 2009 768 776
102. A. Sterr, K. Herron, C. Hayward, and D. Montaldi Are mild head injuries as mild as we think? Neurobehavioral concomitants of chronic post-concussion syndrome BMC Neurology 6 1 2006 7
103. G.E. Strangman, R. Goldstein, T.M. O'Neil-Pirozzi, K. Kelkar, C. Supelana, and D. Burke Neurophysiological alterations during strategy-based verbal learning in traumatic brain injury Neurorehabilitation and Neural Repair 23 3 2009 226 236
104. I.A. Strigo, S.C. Matthews, and A.N. Simmons Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder Psychosomatic Medicine 72 3 2010 316 323
105. I.A. Strigo, A.N. Simmons, S.C. Matthews, E.M. Grimes, C.B. Allard, and L.E. Reinhardt Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence Biological Psychiatry 68 5 2010 442 450
106. G. Tan, B. Fink, T.K. Dao, R. Hebert, L.S. Farmer, and A. Sanders Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study Pain Medicine 10 7 2009 1237 1245
107. K. Thomaes, E. Dorrepaal, N.P. Draijer, M.B. de Ruiter, B.M. Elzinga, and A.J. van Balkom Increased activation of the left hippocampus region in Complex PTSD during encoding and recognition of emotional words: a pilot study Psychiatry Research 171 1 2009 44 53
108. P.E. Turkeltaub, G.F. Eden, K.M. Jones, and T.A. Zeffiro Meta-analysis of the functional neuroanatomy of single-word reading: method and validation NeuroImage 16 3 Pt 1 2002 765 780
109. R.W. Van Boven, G.S. Harrington, D.B. Hackney, A. Ebel, G. Gauger, and J.D. Bremner Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder Journal of Rehabilitation Research and Development 46 6 2009 717 757
110. J.J. Vasterling, M. Verfaellie, and K.D. Sullivan Mild traumatic brain injury and posttraumatic stress disorder in returning veterans: perspectives from cognitive neuroscience Clinical Psychology Review 29 8 2009 674 684
111. N.S. Werner, T. Meindl, R.R. Engel, R. Rosner, M. Riedel, and M. Reiser Hippocampal function during associative learning in patients with posttraumatic stress disorder Journal of Psychiatric Research 43 3 2009 309 318
112. M.G. Whalley, M.D. Rugg, A.P. Smith, R.J. Dolan, and C.R. Brewin Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: an fMRI study Brain and Cognition 69 1 2009 98 107
113. H. Wiese, C. Tonnes, A. de Greiff, K. Nebel, H.C. Diener, and P. Stude Self-initiated movements in chronic prefrontal traumatic brain injury: an event-related functional MRI study NeuroImage 30 4 2006 1292 1301
114. E.A. Wilde, J.V. Hunter, M.R. Newsome, R.S. Scheibel, E.D. Bigler, and J.L. Johnson Frontal and temporal morphometric findings on MRI in children after moderate to severe traumatic brain injury Journal of Neurotrauma 22 3 2005 333 344
115. E.A. Wilde, Z. Chu, E.D. Bigler, J.V. Hunter, M.A. Fearing, and G. Hanten Diffusion tensor imaging in the corpus callosum in children after moderate to severe traumatic brain injury Journal of Neurotrauma 23 10 2006 1412 1426
116. J.E. Wilk, J.L. Thomas, D.M. McGurk, L.A. Riviere, C.A. Castro, and C.W. Hoge Mild traumatic brain injury (concussion) during combat: lack of association of blast mechanism with persistent postconcussive symptoms The Journal of Head Trauma Rehabilitation 25 1 2010 9 14
117. L.M. Williams, A.H. Kemp, K. Felmingham, M. Barton, G. Olivieri, and A. Peduto Trauma modulates amygdala and medial prefrontal responses to consciously attended fear NeuroImage 29 2 2006 347 357
118. B.E. Wojcik, C.R. Stein, K. Bagg, R.J. Humphrey, and J. Orosco Traumatic brain injury hospitalizations of U.S. army soldiers deployed to Afghanistan and Iraq American Journal of Preventive Medicine 38 1 Suppl 2010 S108 S116
119. P. Yang, M.T. Wu, C.C. Hsu, and J.H. Ker Evidence of early neurobiological alternations in adolescents with posttraumatic stress disorder: a functional MRI study Neuroscience Letters 370 1 2004 13 18
120. R. Yehuda Understanding heterogeneous effects of trauma exposure: relevance to postmortem studies of PTSD Psychiatry 67 4 2004 391 397