Neuroimaging in children, adolescents and young adults with psychological trauma

European Child and Adolescent Psychiatry

Volumn 22, Issue 12, 2013, Pages 745-755

  Rinne Albers, Mirjam A W ^a   Van Der Wee, Nic J A ^b   Lamers Winkelman, Francien ^c,d   Vermeiren, Robert R J M ^a,b,c  

^a Acad Ctr Child and Adol Psychiat   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d Kinder en Jeugd Traumacentrum (KJTC)   (Netherlands)

Author keywords

Adolescence; Childhood; Neuroimaging; Review; Trauma

Indexed keywords

AMYGDALOID NUCLEUS; CEREBELLUM; CHILD NEGLECT; CORPUS CALLOSUM; DECLARATIVE MEMORY; DIFFUSION TENSOR IMAGING; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HIPPOCAMPUS; HUMAN; HYPOPHYSIS; JUVENILE; LATERAL BRAIN VENTRICLE; PHYSICAL ABUSE; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PSYCHOTRAUMA; REVIEW; SENSORY CORTEX; SEXUAL ABUSE; SYSTEMATIC REVIEW; UNCINATE FASCICULUS; UNITED STATES; VERBAL HOSTILITY; VISUAL CORTEX;

ADOLESCENT; BRAIN; CHILD; CHILD ABUSE; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; MALE; STRESS DISORDERS, POST-TRAUMATIC; UNITED STATES;

EID: 84890860161     PISSN: 10188827     EISSN: 1435165X     Source Type: Journal    
DOI: 10.1007/s00787-013-0410-1     Document Type: Review

References (62)

1. Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, Aguilar-Gaxiola S, Alhamzawi AO, Alonso J, Angermeyer M, Benjet C, Bromet E, Chatterji S, de Girolamo G, Demyttenaere K, Fayyad J, Florescu S, Gal G, Gureje O, Haro JM, Hu CY, Karam EG, Kawakami N, Lee S, Lepine JP, Ormel J, Posada-Villa J, Sagar R, Tsang A, Ustun TB, Vassilev S, Viana MC, Williams DR (2010) Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry 197:378-385
2. MacMillan HL, Fleming JE, Streiner DL, Lin E, Boyle MH, Jamieson E, Duku EK, Walsh CA, Wong MY, Beardslee WR (2001) Childhood abuse and lifetime psychopathology in a community sample. Am J Psychiatry 158:1878-1883
3. Sanchez MM, Ladd CO, Plotsky PM (2001) Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models. Dev Psychopathol 13:419-449
4. Teicher MH (2002) Scars that won't heal: the neurobiology of child abuse. Sci Am 286:68-75
5. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP (2002) Developmental neurobiology of childhood stress and trauma. Psychiatr Clin North Am 25:397-viii
6. Vermetten E, Bremner JD (2002) Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder. Depress Anxiety 16:14-38
7. Pine DS (2003) Developmental psychobiology and response to threats: relevance to trauma in children and adolescents. Biol Psychiatry 53:796-808
8. Nock MK, Kaufman J, Rosenheck RA (2001) Examination of predictors of severe violence in combat-exposed Vietnam veterans. J Trauma Stress 14:835-841
9. Kaufman J, Plotsky PM, Nemeroff CB, Charney DS (2000) Effects of early adverse experiences on brain structure and function: clinical implications. Biol Psychiatry 48:778-790
10. McCrory E, De Brito SA, Viding E (2010) Research review: the neurobiology and genetics of maltreatment and adversity. J Child Psychol Psychiatry 51:1079-1095
11. Bremner JD, Vermetten E (2001) Stress and development: behavioral and biological consequences. Dev Psychopathol 13:473-489
12. van Harmelen AL, van Tol MJ, van der Wee NJ, Veltman DJ, Aleman A, Spinhoven P, van Buchem MA, Zitman FG, Penninx BW, Elzinga BM (2010) Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biol Psychiatry 68:832-838
13. Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD (2003) Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry 54:693-702
14. Felmingham K, Kemp A, Williams L, Das P, Hughes G, Peduto A, Bryant R (2007) Changes in anterior cingulate and amygdala after cognitive behavior therapy of posttraumatic stress disorder. Psychol Sci 18:127-129
15. Roy MJ, Francis J, Friedlander J, Banks-Williams L, Lande RG, Taylor P, Blair J, McLellan J, Law W, Tarpley V, Patt I, Yu H, Mallinger A, Difede J, Rizzo A, Rothbaum B (2010) Improvement in cerebral function with treatment of posttraumatic stress disorder. Ann N Y Acad Sci 1208:142-149
16. Newport DJ, Stowe ZN, Nemeroff CB (2002) Parental depression: animal models of an adverse life event. Am J Psychiatry 159:1265-1283
17. De Bellis MD, Hooper SR, Woolley DP, Shenk CE (2010) Demographic, maltreatment, and neurobiological correlates of PTSD symptoms in children and adolescents. J Pediatr Psychol 35:570-577
18. De Bellis MD, Keshavan MS (2003) Sex differences in brain maturation in maltreatment-related pediatric posttraumatic stress disorder. Neurosci Biobehav Rev 27:103-117
19. Thomas LA, De B (2004) Pituitary volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 55:752-758
20. Tupler LA, De B (2006) Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder. Biol Psychiatry 59:523-529
21. Karl A, Schaefer M, Malta LS, Dorfel D, Rohleder N, Werner A (2006) A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 30:1004-1031
22. Bremner JD (2007) Neuroimaging in posttraumatic stress disorder and other stress-related disorders. Neuroimaging Clin N Am 17:523-38, ix
23. Carrion VG, Weems CF, Eliez S, Patwardhan A, Brown W, Ray RD, Reiss AL (2001) Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder. Biol Psychiatry 50:943-951
24. De Bellis MD, Hall J, Boring AM, Frustaci K, Moritz G (2001) A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 50:305-309
25. De Bellis MD, Keshavan MS, Clark DB, Casey BJ, Giedd JN, Boring AM, Frustaci K, Ryan ND (1999) A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development. Biol Psychiatry 45:1271-1284
26. Mehta MA, Golembo NI, Nosarti C, Colvert E, Mota A, Williams SC, Rutter M, Sonuga-Barke EJ (2009) Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: the English and Romanian Adoptees study pilot. J Child Psychol Psychiatry 50:943-951
27. De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J, Moritz G (2002) Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry 52:1066-1078
28. Andersen SL, Tomada A, Vincow ES, Valente E, Polcari A, Teicher MH (2008) Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. J Neuropsychiatry Clin Neurosci 20:292-301
29. Choi J, Jeong B, Rohan ML, Polcari AM, Teicher MH (2009) Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse. Biol Psychiatry 65:227-234
30. Carrion VG, Weems CF, Reiss AL (2007) Stress predicts brain changes in children: a pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus. Pediatrics 119:509-516
31. Woon FL, Hedges DW (2008) Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus 18:729-736
32. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, Pitman RK (2002) Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 5:1242-1247
33. Yehuda R, Golier JA, Tischler L, Harvey PD, Newmark R, Yang RK, Buchsbaum MS (2007) Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: relation to risk and resilience factors. J Psychiatr Res 41:435-445
34. Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL (2004) Childhood neglect is associated with reduced corpus callosum area. Biol Psychiatry 56:80-85
35. Jackowski AP, Douglas-Palumberi H, Jackowski M, Win L, Schultz RT, Staib LW, Krystal JH, Kaufman J (2008) Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study. Psychiatry Res 162:256-261
36. Jackowski AP, de Araujo CM, de Lacerda AL, Mari JJ, Kaufman J (2009) Neurostructural imaging findings in children with post-traumatic stress disorder: brief review. Psychiatry Clin Neurosci 63:1-8
37. Kitayama N, Brummer M, Hertz L, Quinn S, Kim Y, Bremner JD (2007) Morphologic alterations in the corpus callosum in abuse-related posttraumatic stress disorder: a preliminary study. J Nerv Ment Dis 195:1027-1029
38. Villarreal G, Hamilton DA, Graham DP, Driscoll I, Qualls C, Petropoulos H, Brooks WM (2004) Reduced area of the corpus callosum in posttraumatic stress disorder. Psychiatry Res 131:227-235
39. Hanson JL, Chung MK, Avants BB, Shirtcliff EA, Gee JC, Davidson RJ, Pollak SD (2010) Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk. J Neurosci 30:7466-7472
40. Tomoda A, Suzuki H, Rabi K, Sheu YS, Polcari A, Teicher MH (2009) Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment. Neuroimage 47(Suppl 2):T66-T71
41. Carrion VG, Weems CF, Watson C, Eliez S, Menon V, Reiss AL (2009) Converging evidence for abnormalities of the prefrontal cortex and evaluation of midsagittal structures in pediatric posttraumatic stress disorder: an MRI study. Psychiatry Res 172:226-234
42. Richert KA, Carrion VG, Karchemskiy A, Reiss AL (2006) Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study. Depress Anxiety 23:17-25
43. Mana S, Paillere Martinot ML, Martinot JL (2010) Brain imaging findings in children and adolescents with mental disorders: a cross-sectional review. Eur Psychiatry 25:345-354
44. Tomoda A, Navalta CP, Polcari A, Sadato N, Teicher MH (2009) Childhood sexual abuse is associated with reduced gray matter volume in visual cortex of young women. Biol Psychiatry 66:642-648
45. Choi J, Jeong B, Polcari A, Rohan ML, Teicher MH (2012) Reduced fractional anisotropy in the visual limbic pathway of young adults witnessing domestic violence in childhood. Neuroimage 59:1071-1079
46. Tomoda A, Sheu YS, Rabi K, Suzuki H, Navalta CP, Polcari A, Teicher MH (2011) Exposure to parental verbal abuse is associated with increased gray matter volume in superior temporal gyrus. Neuroimage 54(Suppl 1):S280-S286
47. Durston S (2008) Converging methods in studying attention-deficit/ hyperactivity disorder: what can we learn from neuroimaging and genetics? Dev Psychopathol 20:1133-1143
48. De Bellis MD, Kuchibhatla M (2006) Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 60:697-703
49. Baldacara L, Jackowski AP, Schoedl A, Pupo M, Andreoli SB, Mello MF, Lacerda AL, Mari JJ, Bressan RA (2011) Reduced cerebellar left hemisphere and vermal volume in adults with PTSD from a community sample. J Psychiatr Res 45:1627-1633
50. Eluvathingal TJ, Chugani HT, Behen ME, Juhasz C, Muzik O, Maqbool M, Chugani DC, Makki M (2006) Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study. Pediatrics 117:2093-2100
51. Ayling E, Aghajani M, Fouche JP, van der Wee N (2012) Diffusion tensor imaging in anxiety disorders. Curr Psychiatry Rep 14:197-202
52. Yang P, Wu MT, Hsu CC, Ker JH (2004) Evidence of early neurobiological alternations in adolescents with posttraumatic stress disorder: a functional MRI study. Neurosci Lett 370:13-18
53. Carrion VG, Garrett A, Menon V, Weems CF, Reiss AL (2008) Posttraumatic stress symptoms and brain function during a response-inhibition task: an fMRI study in youth. Depress Anxiety 25:514-526
54. Carrion VG, Haas BW, Garrett A, Song S, Reiss AL (2010) Reduced hippocampal activity in youth with posttraumatic stress symptoms: an FMRI study. J Pediatr Psychol 35:559-569
55. Konrad K, Eickhoff SB (2010) Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Hum Brain Mapp 31:904-916
56. Williams DL, Minshew NJ (2007) Understanding autism and related disorders: what has imaging taught us? Neuroimaging Clin N Am 17:495-509, ix
57. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) study. Am J Prev Med 14:245-258
58. Bryant RA, Felmingham K, Kemp A, Das P, Hughes G, Peduto A, Williams L (2008) Amygdala and ventral anterior cingulate activation predicts treatment response to cognitive behaviour therapy for post-traumatic stress disorder. Psychol Med 38:555-561
59. Frewen PA, Dozois DJ, Lanius RA (2008) Neuroimaging studies of psychological interventions for mood and anxiety disorders: empirical and methodological review. Clin Psychol Rev 28:228-246
60. Nardo D, Hogberg G, Looi JC, Larsson S, Hallstrom T, Pagani M (2010) Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients. J Psychiatr Res 44:477-485
61. Pine DS (2007) Research review: a neuroscience framework for pediatric anxiety disorders. J Child Psychol Psychiatry 48:631-648
62. Shonkoff JP (2011) Protecting brains, not simply stimulating minds. Science 333:982-983