Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

Osteoarthritis and Cartilage

Volumn 22, Issue 8, 2014, Pages 1167-1175

  Fahy, N ^a,b   de Vries van Melle, M L ^b   Lehmann, J ^b   Wei, W ^b   Grotenhuis, N ^b   Farrell, E ^a,b   van der Kraan, P M ^c   Murphy, J M ^a   Bastiaansen Jenniskens, Y M ^b   van Osch, G J V M ^b  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chondrogenesis; Inflammation; Macrophage; Mesenchymal stem cells; Osteoarthritis

Indexed keywords

AGGRECAN; BIOLOGICAL MARKER; CD206 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; COLLAGEN TYPE 2; INTERLEUKIN 6; PROTEIN; PROTEIN CCL18; PROTEIN MRC1; UNCLASSIFIED DRUG; ACAN PROTEIN, HUMAN; BETA CHEMOKINE; CCL18 PROTEIN, HUMAN; CD86 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; CULTURE MEDIUM; IL6 PROTEIN, HUMAN; LECTIN; MANNOSE BINDING LECTIN; MANNOSE RECEPTOR; MESSENGER RNA;

ADULT; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CHONDROGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA CONTENT; FEMALE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MESENCHYMAL STEM CELL; OSTEOARTHRITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; SYNOVIOCYTE; SYNOVIUM; AGED; ARTICULAR CARTILAGE; CARTILAGE CELL; CULTURE MEDIUM; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; MONOCYTE; SYNOVIAL FLUID;

ADULT; AGED; AGGRECANS; ANTIGENS, CD86; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CHEMOKINES, CC; CHONDROCYTES; CHONDROGENESIS; COLLAGEN TYPE II; CULTURE MEDIA, CONDITIONED; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN-6; LECTINS, C-TYPE; MACROPHAGES; MALE; MANNOSE-BINDING LECTINS; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; MONOCYTES; OSTEOARTHRITIS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 84905588451     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.05.021     Document Type: Article

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