Liposomal Targeting of Prednisolone Phosphate to Synovial Lining Macrophages during Experimental Arthritis Inhibits M1 Activation but Does Not Favor M2 Differentiation

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Hofkens, Wouter ^a   Schelbergen, Rik ^a   Storm, Gert ^b   van den Berg, Wim B ^a   van Lent, Peter L ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD163 ANTIGEN; CD206 PROTEIN; CD86 ANTIGEN; CELL PROTEIN; CIITA PROTEIN; FC RECEPTOR; GAMMA INTERFERON; GLUCOCORTICOID; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PREDNISOLONE SODIUM PHOSPHATE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; YM1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL INFILTRATION; CELL PHAGOCYTOSIS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; JOINT SWELLING; LIPOSOMAL DELIVERY; MACROPHAGE ACTIVATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVITIS; UPREGULATION;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION PROFILING; INFLAMMATION; LIPOSOMES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; PHENOTYPE; PREDNISOLONE; SYNOVIAL MEMBRANE;

EID: 84874522489     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054016     Document Type: Article

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