Profiling the Secretion of Soluble Mediators by End Stage Osteoarthritis Synovial Tissue Explants Reveals a Reduced Responsiveness to an Inflammatory Trigger

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Gierman, Lobke M ^a,b   van El, Benno ^a   van der Ham, Frits ^a   Koudijs, Angela ^a   Stoop, Reinout ^a   Verheijen, Jan H ^a   Kloppenburg, Margreet ^b   van Osch, Gerjo J V M ^c   Stojanovic Susulic, Vedrana ^d   Huizinga, Tom W J ^b   Zuurmond, Anne Marie ^a  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Biologics Clinical Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; INTERLEUKIN 1ALPHA; MATRIX METALLOPROTEINASE; AUTACOID;

ADULT; AGED; ARTICLE; BODY MASS; CARTILAGE DEGENERATION; COCULTURE; CONTROLLED STUDY; DISEASE COURSE; EXPLANT; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATION; KNEE OSTEOARTHRITIS; MALE; SYNOVIUM; ADOLESCENT; ANIMAL; ARTICULAR CARTILAGE; BIOSYNTHESIS; BOVINE; DRUG EFFECTS; IMMUNOLOGY; JOINT CAPSULE; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS; SECRETION (PROCESS); TISSUE CULTURE TECHNIQUE;

BOVINAE;

ADOLESCENT; AGED; ANIMALS; CARTILAGE, ARTICULAR; CATTLE; GLYCOSAMINOGLYCANS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1ALPHA; JOINT CAPSULE; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; OSTEOARTHRITIS; TISSUE CULTURE TECHNIQUES;

EID: 84877057789     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062634     Document Type: Article

References (24)

1. Arden N, Nevitt MC, (2006) Osteoarthritis: Epidemiology. Best Pract Res Clin Rheumatol 20: 3-25.
2. Hunter DJ, Felson DT, (2006) Osteoarthritis. BMJ 332: 639-642.
3. Musumeci G, Loreto C, Carnazza ML, Martinez G, (2011) Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis. Knee Surg Sports Traumatol Arthrosc 19: 307-313.
4. Hunter DJ, (2009) Risk stratification for knee osteoarthritis progression: A narrative review. Osteoarthritis Cartilage 17: 1402-1407.
5. Brandt KD, Radin EL, Dieppe PA, van de Putte L, (2006) Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 65: 1261-1264.
6. Goldring MB, Otero M, (2011) Inflammation in osteoarthritis. Curr Opin Rheumatol 23: 471-478.
7. Sellam J, Berenbaum F, (2010) The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 6: 625-635.
8. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B, (2005) Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 64: 1263-1267.
9. Attur M, Samuels J, Krasnokutsky S, Abramson SB, (2010) Targeting the synovial tissue for treating osteoarthritis (OA): Where is the evidence? Best Pract Res Clin Rheumatol 24: 71-79.
10. Piecha D, Weik J, Kheil H, Becher G, Timmermann A, et al. (2010) Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. Inflamm Res 59: 379-389.
11. Pretzel D, Pohlers D, Weinert S, Kinne RW, (2009) In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage. Arthritis Res Ther 11: R25.
12. Deiters B, Prehm P, (2008) Inhibition of hyaluronan export reduces collagen degradation in interleukin-1 treated cartilage. Arthritis Res Ther 10: R8.
13. Beekman B, Drijfhout JW, Ronday HK, TeKoppele JM, (1999) Fluorogenic MMP activity assay for plasma including MMPs complexed to alpha 2-macroglobulin. Ann N Y Acad Sci 878: 150-158.
14. Farahat MN, Yanni G, Poston R, Panayi GS, (1993) Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 52: 870-875.
15. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H, (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7: 33-42.
16. Bonnet CS, Walsh DA, (2005) Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 44: 7-16.
17. Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E, et al. (2011) Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop 35: 831-838.
18. Jacques C, Gosset M, Berenbaum F, Gabay C, (2006) The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation. Vitam Horm 74: 371-403.
19. Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M, (1997) Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 24: 365-371.
20. Goldenberg DL, Egan MS, Cohen AS, (1982) Inflammatory synovitis in degenerative joint disease. J Rheumatol 9: 204-209.
21. Roemer FW, Guermazi A, Felson DT, Niu J, Nevitt MC, et al. (2011) Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: The MOST study. Ann Rheum Dis 70: 1804-1809.
22. Beekhuizen M, Bastiaansen-Jenniskens YM, Koevoet W, Saris DB, Dhert WJ, et al. (2011) Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage-synovium coculture. Arthritis Rheum 63: 1918-1927.
23. Jackson JR, Minton JA, Ho ML, Wei N, Winkler JD, (1997) Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta. J Rheumatol 24: 1253-1259.
24. Yang S, Kim J, Ryu JH, Oh H, Chun CH, et al. (2010) Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 16: 687-693.