Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-α but not IL-1β treatment at a post-transcriptional level in bovine cartilage explants

Osteoarthritis and Cartilage

Volumn 16, Issue 4, 2008, Pages 489-497

  Stevens, A L ^a   Wheeler, C A ^a   Tannenbaum, S R ^a,b   Grodzinsky, A J ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c USA   (United States)

Author keywords

Aggrecan; Aggrecanase; Interleukin 1; Matrix degradation; Nitric oxide; Tumor necrosis factor alpha

Indexed keywords

A DISINTEGRIN AND MATRIX METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF 4 PROTEIN; A DISINTEGRIN AND MATRIX METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF 5 PROTEIN; AGGRECAN; AGGRECANASE; COLLAGEN TYPE 2; COLLAGENASE 3; CYCLOOXYGENASE 2; FIBROMODULIN; GELATINASE B; GLYCOSAMINOGLYCAN POLYSULFATE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LINK PROTEIN; MATRIX METALLOPROTEINASE; N METHYL ARGININE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PROTEINASE; STROMELYSIN; TISSUE CULTURE MEDIUM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARTILAGE; CONTROLLED STUDY; COW; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME RELEASE; EXPLANT; EXTRACELLULAR MATRIX; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

AGGRECANS; ANIMALS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CATTLE; COLLAGENASES; ELECTROPHORESIS; ENDOPEPTIDASES; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; GLYCOSAMINOGLYCANS; INTERLEUKIN-1BETA; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 41149093664     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.07.015     Document Type: Article

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