Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models

European Journal of Pharmacology

Volumn 740, Issue , 2014, Pages 72-80

  Ongerth, Tanja ^a   Russmann, Vera ^a   Fischborn, Sarah ^a   Boes, Katharina ^a   Siegl, Claudia ^a   Potschka, Heidrun ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anti epileptic drug; Epilepsy; Hippocampus; Neuroprotection; Potassium channel; TRAM 34

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN4 PROTEIN, RAT; POTASSIUM CHANNEL BLOCKING AGENT; PYRAZOLE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; EPILEPSY, TEMPORAL LOBE; FEMALE; HIPPOCAMPUS; METABOLISM; MICROGLIA; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; STATUS EPILEPTICUS;

ANIMALS; EPILEPSY, TEMPORAL LOBE; FEMALE; HIPPOCAMPUS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICROGLIA; NEURONS; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS;

EID: 84905571471     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.06.061     Document Type: Article

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