Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development

Journal of Neurochemistry

Volumn 105, Issue 2, 2008, Pages 389-400

  Pekcec, Anton ^a   Fuest, Christina ^a   Mühlenhoff, Martina ^b   Gerardy Schahn, Rita ^b   Potschka, Heidrun ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Epilepsy; Epileptogenesis; Neurogenesis; Polysialic acid neural cell adhesion molecule; Spatial learning

Indexed keywords

ENDONEURAMINIDASE; NERVE CELL ADHESION MOLECULE; POLYSIALIC ACID; SIALIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLYSIALYLATION; EPILEPSY; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPUS; LEARNING DISORDER; MALE; MAZE TEST; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIALYLATION;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BROMODEOXYURIDINE; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GLYCOSIDE HYDROLASES; HIPPOCAMPUS; MALE; MAZE LEARNING; NEURAL CELL ADHESION MOLECULES; NEURONS; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY; SIALIC ACIDS; STATUS EPILEPTICUS; TIME FACTORS;

RATTUS;

EID: 41749090488     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05172.x     Document Type: Article

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