Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome

Journal of Pathology

Volumn 223, Issue 5, 2011, Pages 584-592

  Lai, Cecilia ^a   Robinson, James ^a   Clark, Sue ^b   Stamp, Gordon ^c   Poulsom, Richard ^c   Silver, Andrew ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ST MARK S HOSPITAL   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

LKB1; PJS; Polyp; WNT5A

Indexed keywords

BETA CATENIN; CYCLIN D1; CYCLIN D2; DIXDC1 PROTEIN; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOPROTEIN PHOSPHATASE 2 REGULATORY SUBUNIT B BETA ISOFORM; PROTEIN KINASE LKB1; PROTEIN PHOSPHATASE 3 CATALYTIC SUBUNIT ALPHA ISOFORM; SECRETED FRIZZLED RELATED PROTEIN 4; UNCLASSIFIED DRUG; WIF1 PROTEIN; WNT PROTEIN; WNT11 PROTEIN; WNT5A PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASE REPORT; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE MUCOSA; INTESTINE POLYP; MALE; MOUSE; NONHUMAN; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STOMACH POLYP; STROMA; TRANSCRIPTION REGULATION;

ANIMALS; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTESTINAL MUCOSA; MALE; MICE; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEUTZ-JEGHERS SYNDROME; POLYPS; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; STOMACH DISEASES; WNT PROTEINS;

EID: 79952555964     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2835     Document Type: Article

References (43)

1. Jasperson KW, Tuohy TM, Neklason DW, et al. Hereditary and familial colon cancer. Gastroenterology 2010; 138: 2044-2058.
2. Hearle N, Schumacher V, Menko FH, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res 2006; 12: 3209-3215. (Pubitemid 43837371)
3. Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008; 27: 6908-6919.
4. Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature Rev Cancer 2009; 9: 563-575.
5. Wingo SN, Gallardo TD, Akbay EA, et al. Somatic LKB1 mutations promote cervical cancer progression. PLoS One 2009; 4: e5137.
6. Esteller M, Avizienyte E, Corn PG, et al. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene 2000; 19: 164-168. (Pubitemid 30066364)
7. Jishage K, Nezu J, Kawase Y, et al. Role of Lkb1, the causative gene of Peutz-Jeghers syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A 2002; 99: 8903-8908. (Pubitemid 34693656)
8. Miyoshi H, Nakau M, Ishikawa TO, et al. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 2002; 62: 2261-2266. (Pubitemid 34411702)
9. Rossi DJ, Ylikorkala A, Korsisaari N, et al. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci U S A 2002; 99: 12327-12332.
10. Pearson HB, McCarthy A, Collins CM, et al. Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 2008; 68: 2223-2232.
11. Contreras CM, Gurumurthy S, Haynie JM, et al. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res 2008; 68: 759-766. (Pubitemid 351206752)
12. Londesborough A, Vaahtomeri K, Tiainen M, et al. LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment. Development 2008; 135: 2331-2338.
13. Katajisto P, Vaahtomeri K, Ekman N, et al. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nature Genet 2008; 40: 455-459. (Pubitemid 351450888)
14. Vaahtomeri K, Ventela E, Laajanen K, et al. Lkb1 is required for TGFbeta-mediated myofibroblast differentiation. J Cell Sci 2008; 121: 3531-3540.
15. Back W, Loff S, Jenne D, et al. Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromes. J Clin Pathol 1999; 52: 345-349. (Pubitemid 29200025)
16. De Leng WW, Westerman AM, Weterman MA, et al. Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. Clin Cancer Res 2003; 9: 3065-3072. (Pubitemid 36993269)
17. Miyaki M, Iijima T, Hosono K, et al. Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Cancer Res 2000; 60: 6311-6313.
18. Spicer J, Rayter S, Young N, et al. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 2003; 22: 4752-4756. (Pubitemid 36976450)
19. Lin-Marq N, Borel C, Antonarakis SE. Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Mol Genet Genomics 2005; 273: 184-196. (Pubitemid 40674718)
20. Ossipova O, Bardeesy N, DePinho RA, et al. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nature Cell Biol 2003; 5: 889-894. (Pubitemid 37220694)
21. Marignani PA. LKB1, the multitasking tumour suppressor kinase. J Clin Pathol 2005; 58: 15-19. (Pubitemid 40070489)
22. Volikos E, Robinson J, Aittomaki K, et al. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet 2006; 43: e18.
23. Raychaudhuri S, Stuart JM, Altman RB. Principal components analysis to summarize microarray experiments: application to sporulation time series. Pac Symp Biocomput 2000; 455-466.
24. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80.
25. Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000; 28: 27-30. (Pubitemid 30047706)
26. Sawyer EJ, Hanby AM, Rowan AJ, et al. The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours. J Pathol 2002; 196: 437-444. (Pubitemid 34262856)
27. Poulsom R, Longcroft JM, Jeffery RE, et al. A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens. Eur J Histochem 1998; 42: 121-132. (Pubitemid 28362310)
28. Yanglin P, Lina Z, Zhiguo L, et al. KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells. Cancer Lett 2007; 246: 129-138. (Pubitemid 44959384)
29. Mottershead M, Karteris, E, Barclay JY, et al. Immunohistochemical and quantitative mRNA assessment of ghrelin expression in gastric and oesophageal adenocarcinoma. J Clin Pathol 2007; 60: 405-409. (Pubitemid 46596560)
30. Aung PP, Mitani, Y, Sanada Y, et al. Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas. Virchows Arch 2006; 448: 428-434.
31. Kinugasa T, Huo Q, Higashi D, et al. Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer. Anticancer Res 2007; 27: 3729-3734. (Pubitemid 47598437)
32. Gupta N, Miyauchi S, Martindale RG, et al. Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Biochim Biophys Acta 2005; 1741: 215-223. (Pubitemid 40825007)
33. Fodde R, Tomlinson I. Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma. J Pathol 2010; 221: 239-241.
34. Hassan A,Yerian LM,Kuan SF, et al. Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps. Hum Pathol 2004; 35: 328-334.
35. Gaspar C, Cardoso J, Franken P, et al. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol 2008; 172: 1363-1380. (Pubitemid 351671549)
36. Segditsas S, Sieber O, Deheragoda M, et al. Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet 2008; 17: 3864-3875. (Pubitemid 352762849)
37. McDonald SL, Silver A. The opposing roles of Wnt-5a in cancer. Br J Cancer 2009; 101: 209-214.
38. Dejmek J, Dejmek A, Safholm A, et al. Wnt-5a protein expression in primary Dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 2005; 65: 9142-9146. (Pubitemid 41507974)
39. Kurayoshi M, Oue N, Yamamoto H, et al. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 2006; 66: 10439-10448. (Pubitemid 44799765)
40. Lee JM, Kim IS, Kim H, et al. RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. Mol Cell 2010; 37: 183-195.
41. Cheng CW,Yeh JC, Fan TP, et al. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun 2008; 365: 285-290.
42. Masckauchan TN, Agalliu D, Vorontchikhina M, et al. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell 2006; 17: 5163-5172. (Pubitemid 44907359)
43. Robinson J, Lai C, Martin A, et al. Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice. J Pathol 2009; 219: 35-40.