Patient safety and beyond: What should we expect from microneedle arrays in the transdermal delivery arena?

Therapeutic Delivery

Volumn 5, Issue 6, 2014, Pages 653-662

  Donnelly, Ryan F ^a   Woolfson, A David ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COSMETIC;

HEALTH CARE PERSONNEL; HUMAN; MICRONEEDLE; OPTICAL COHERENCE TOMOGRAPHY; PATIENT INFORMATION; PATIENT MONITORING; PATIENT SAFETY; PRIORITY JOURNAL; REVIEW; SKIN WATER LOSS; TRANSDERMAL DRUG ADMINISTRATION; VACCINATION;

ADMINISTRATION, CUTANEOUS; DRUG DELIVERY SYSTEMS; HUMANS; MICROINJECTIONS; NEEDLES; PATIENT SAFETY;

EID: 84905502180     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.14.29     Document Type: Review

References (47)

1. Pharmaceutical and Medical Packaging News (PMPN) Magazine. www.pmpnews.com/news/transdermal-delivery-marketpredictedreach-315-billion-2015- pharmalive-special-report
2. Donnelly RF, Thakur RRS, Morrow DIJ et al. Microneedlemediated Transdermal and Intradermal Drug Delivery. Wiley-Blackwell, Oxford, UK (2012).
3. Greystone Associates. Microneedles in Medicine: Technology, Devices, Markets and Prospects. Greystone Associates, NH, USA (2012).
4. Chow AY, Pardue MT, Chow VY et al. Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans. Neural. Syst. Rehabil. Eng. 9, 86-95 (2001).
5. Voskerician G, Shive MS, Langer R et al. Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials 24, 1959-1967 (2003).
6. Schmidt S, Horch K, Normann R. Biocompatibility of silicon-based electrode arrays implanted in feline cortical tissue. J. Biomed. Mater. Res. 27, 1393-1399 (1993).
7. Pierre MB, Rossetti FC. Microneedle-based drug-delivery systems for transdermal route. Curr. Drug Targets 15, 281-291 (2014).
8. Donnelly RF, Morrow DIJ, Thakur RRS et al. Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev. Indust. Pharm. 35, 1242-1254 (2009).
9. Migalska K, Morrow DIJ, Donnelly RF et al. Laserengineered dissolving microneedle arrays for transdermal macromolecular drug delivery. Pharm. Res. 28, 1919-1930 (2011).
10. Garland MJ, Caffarel-Salvador E, Donnelly RF et al. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery. J. Control. Release 159, 52-59 (2012).
11. Demir YK, Akan Z, Kerimoglu O. Characterization of polymeric microneedle arrays for transdermal drug delivery. PLoS ONE 8, e77289 (2013).
12. Park JH, Prausnitz MR. Analysis of mechanical failure of polymer microneedles by axial force. J. Korean Phys. Soc. 56, 1223-1227 (2010).
13. Donnelly RF, Thakur RRS, Garland MJ et al. Hydrogelforming microneedle arrays for enhanced transdermal drug delivery. Adv. Funct. Mater. 22, 4879-4890 (2012).
14. Gerstel MS, Place VA: US3964482 (1976).
15. Henry S, McAllister DV, Prausnitz MR et al. Microfabricated microneedles: a novel approach to transdermal drug delivery. J. Pharm. Sci. 87, 922-925 (1998).
16. McCrudden MTC, Thakur RRS, Donnelly RF et al. Strategies for enhanced peptide and protein delivery. Ther. Deliv. 4, 593-614 (2013).
17. Zaric M, Donnelly RF, Kissenpfennig A et al. Targeting of skin dendritic cells via microneedle arrays laden with antigen encapsulated PLGA nanoparticles induces efficient anti-tumour and anti-viral immune responses. ACS Nano. 7, 2042-2055 (2013).
18. Koutsonanos DG, Compans RW, Skountzou I. Targeting the skin for microneedle delivery of influenza vaccine. Adv. Exp. Med. Biol. 785, 121-132 (2013).
19. McCrudden MTC, McCrudden C, Donnelly RF et al. Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs. J. Control. Release (In Press) (2014).
20. Raphael AP, Crichton ML, Kendall MA et al. Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays. Small 16, 1785-1793 (2010).
21. Donnelly RF, McCrudden MTC, McAlister E et al. Hydrogel-forming microneedles prepared from "super swelling" polymers enhance transdermal drug and protein delivery when combined with lyophilised wafers. Adv Healthcare Mater. (In Press) (2014).
22. Patel SR., Lin AS, Prausnitz MR et al. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm. Res. 28, 166-176 (2011).
23. Lee CY, You YS, Lee SH et al. Tower microneedle minimizes vitreal reflux in intravitreal injection. Biomed. Microdev. 15, 841-848 (2013).
24. Park KY, Kim HK, Kim SE et al. Treatment of striae distensae using needling therapy: A pilot study. Dermatolog. Surg. 38, 1823-1828 (2013).
25. Seo KY, Kim DH, Lee SE et al. Skin rejuvenation by microneedle fractional radiofrequency and a human stem cell conditioned medium in Asian skin: a randomized controlled investigator blinded split-face study. J. Cosmet. Laser Ther. 15, 25-33 (2013).
26. Donnelly RF, Mooney K, Caffarel-Salvador E et al. Microneedle-mediated minimally-invasive patient monitoring. Ther. Drug Monitor. (In Press) (2014).
27. Coffey JW, Corrie SR, Kendall MA. Early circulating biomarker detection using a wearable microprojection array skin patch. Biomaterials 34, 9572-9583 (2013).
28. Yeow B, Coffey JW, Kendall MA et al. Surface modification and characterization of polycarbonate microdevices for capture of circulating biomarkers, both in vitro and in vivo. Anal. Chem. 85, 10196-10204 (2013).
29. Enfield J, OMahony C, Leahy M et al. In vivo dynamic characterization of microneedle skin penetration using optical coherence tomography. J. Biomed. Opt. 15, 046001 (2010).
30. Coulman S., Birchall, J.C., Alex, A. In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharm. Res. 28, 66-81 (2011).
31. Donnelly RF, Garland MJ, Morrow DIJ et al. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. J. Control. Release 147, 333-341 (2011).
32. Thakur RRS, Dunne NJ, Donnelly RF et al. Review of patents on microneedle applicators. Recent Pat. Drug Deliv. Formul. 5, 11-23 (2011).
33. Donnelly, R.F., Moffatt, K., Zaid-Alkilani, A et al. Hydrogel-forming microneedle arrays can be effectively inserted in skin by self-application: A pilot study centred on pharmacist intervention and a patient information leaflet. Pharm. Res. (In Press) (2014).
34. Norman JJ, Meltzer MI, Prausnitz MR et al. Microneedle patches: Usability and acceptability for self-vaccination against influenza. Vaccine (In Press) (2014).
35. Birchall JC, Anstey A, John D et al. Microneedles in clinical practice: An explanatory study into the views and opinions of healthcare professionals and the public Pharm. Res. 28, 95-106 (2011).
36. Mooney K, McElnay JC, Donnelly RF. Childrens views on microneedle use as an alternative to blood sampling for patient monitoring. Int. J. Pharm. Pract. doi:10.1111/ijpp.12081 (2014) (Epub ahead of print).
37. Daily Mail. www.dailymail.co.uk/femail/article-2026700/Microneedle- Therapy-System-potentially-lethal-Chinese-women-warned. html
38. Soltani-Arabshahi R, Wong JW, Duffy KL et al. Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation. JAMA Dermatol. doi:10.1001/jamadermatol.6955 (2013) (Epub ahead of print).
39. Roby KD, Nardo AD. Innate immunity and the role of the antimicrobial peptide cathelicidin in inflammatory skin disease. Drug Discov. Today Dis. Mech. 10, 3-4 (2013).
40. Donnelly RF, Thakur RRS, Tunney MM et al. Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro. Pharm. Res. 26, 2513-2522 (2009).
41. Wei-Ze L, Mei-Ronga H, Jian-Pinga Z. Super-short solid silicon microneedles for transdermal drug delivery applications Int. J. Pharm. 389, 122-129 (2010).
42. Zosano Pharma website. www.zosanopharma.com/index.php?option=com- content&task=blogcategory&id=26&Itemid=169
43. Nanopass website. www.nanopass.com
44. 3M website. http://solutions.3m.com/wps/portal/3M/en-WW/ DrugDeliverySystems/DDSD/technology-solutions/transdermal-technologies/ microstructured-transdermalsystems
45. Beckton-Dickinson website. www.bdbiosciences.com
46. Corium website. www.coriumgroup.com
47. LTS website. www.ltslohmann.de/home.html