Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells

Biochemical Pharmacology

Volumn 91, Issue 1, 2014, Pages 18-30

  Hamm, R ^a   Chen, Y R ^b   Seo, Ean Jeong ^a   Zeino, Maen ^a   Wu, Ching Fen ^a   Muller R ^c   Yang, N S ^b   Efferth, T ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Archazolid B; Cholesterol biosynthesis; Fluvastatin; LDL uptake; SREBP; V ATPase inhibition

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ARCHAZOLID B; CHOLESTEROL; ENZYME INHIBITOR; FLUINDOSTATIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ARCHAZOLID B; CHOLESTEROL BIOSYNTHESIS; FLUVASTATIN; LDL UPTAKE; SREBP; V-ATPASE INHIBITION.;

CELL LINE, TUMOR; CELL SURVIVAL; CHOLESTEROL; DRUG RESISTANCE, NEOPLASM; ENDOCYTOSIS; FATTY ACIDS, MONOUNSATURATED; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; LIPOPROTEINS, LDL; MACROLIDES; MICRORNAS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LDL; REPRODUCIBILITY OF RESULTS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THIAZOLES; URINARY BLADDER NEOPLASMS;

EID: 84905500466     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.06.018     Document Type: Article

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