Human leptin protein activates the growth of HepG2 cells by inhibiting PERK-mediated ER stress and apoptosis

Molecular Medicine Reports

Volumn 10, Issue 3, 2014, Pages 1649-1655

  Xiong, Ying ^a   Zhang, Jie ^a   Liu, Man ^a   An, Mingwei ^b   Lei, Ling ^a   Guo, Wuhua ^a  

^a NANCHANG UNIVERSITY   (China)

^b Jiang Xi University of Traditional Chinese Medicine   (China)

Author keywords

Apoptosis; Caspase 12; Endoplasmic reticulum stress; Leptin; Phosphorylated PKR like endoplasmic reticulum kinase

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 12; CISPLATIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INOSITOL REQUIRING PROTEIN 1; LEPTIN; MESSENGER RNA; PHOSPHOTRANSFERASE; PKR LIKE ER KINASE; PROTEIN; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; APLP2 PROTEIN, HUMAN; ATF6 PROTEIN, HUMAN; CASP12 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; NERVE PROTEIN; PROTEIN KINASE R; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DNA FRAGMENTATION ASSAY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CANCER; LIVER CANCER CELL LINE; NICK END LABELING; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; XTT ASSAY; GENETICS; METABOLISM; TUNEL ASSAY;

ACTIVATING TRANSCRIPTION FACTOR 6; AMYLOID BETA-PROTEIN PRECURSOR; APOPTOSIS; CASPASE 12; CELL PROLIFERATION; CISPLATIN; DNA FRAGMENTATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; HEP G2 CELLS; HUMANS; IN SITU NICK-END LABELING; LEPTIN; NERVE TISSUE PROTEINS; RNA, SMALL INTERFERING; UNFOLDED PROTEIN RESPONSE;

EID: 84905482260     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2373     Document Type: Article

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