Equol induced apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 but not MCF-7 cells

Molecular Medicine Reports

Volumn 1, Issue 2, 2008, Pages 239-244

  Eun, Jeong Choi ^a   Kim, Taehee ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Breast cancer; Cell cycle; Cell proliferation; Equol

Indexed keywords

CYCLINE; CYTOCHROME C; EQUOL; PROTEIN BAX; REGULATOR PROTEIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

EID: 57349194677     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001. (Pubitemid 32467043)
2. Liu MC, Marshall JL and Pestell RG: Novel strategies in cancer therapeutics: targeting enzymes involved in cell cycle regulation and cellular proliferation. Curr Cancer Drug Targets 4: 403-424, 2004.
3. Kohn KW, Jackman J and O'Connor PM: Cell cycle control and cancer chemotherapy. J Cell Biochem 54: 440-452, 1994. (Pubitemid 24131349)
4. Afroze T and Husain M: Cell cycle dependent regulation of intracellular calcium concentration in vascular smooth muscle cells: a potential target for drug therapy. Curr Drug Targets Cardiovasc Haematol Disord 1: 23-40, 2001.
5. Gardner SN: Cell cycle phase-specific chemotherapy: computational methods for guiding treatment. Cell Cycle 1: 369-374, 2002.
6. Le Marchand L: Cancer preventive effects of flavonoids - a review. Biomed Pharmacother 56: 296-301, 2002.
7. Ren W, Qiao Z, Wang H, Zhu L and Zhang L: Flavonoids: promising anticancer agents. Med Res Rev 23: 519-534, 2003.
8. Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT and Lee MT: The antitumor activities of flavonoids. In Vivo 19: 895-909, 2005.
9. Wu AH, Ziegler RG, Horn-Ross PL, Nomura AM, West DW, Kolonel LN, Rosenthal JF, Hoover RN and Pike MC: Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol Biomarkers Prev 5: 901-906, 1996. (Pubitemid 26382984)
10. Wu AH, Ziegler RG, Nomura AM, West DW, Kolonel LN, Horn-Ross PL, Hoover RN and Pike MC: Soy intake and risk of breast cancer in Asians and Asian Americans. Am J Clin Nutr 68: 1437S-1443S, 1998.
11. Yang D, Bernstein L and Wu AH: Physical activity and breast cancer risk among Asian-American women in Los Angeles: a case-control study. Cancer 97: 2565-2575, 2003. (Pubitemid 36542496)
12. Neuhouser ML: Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer 50: 1-7, 2004. (Pubitemid 39587599)
13. Bosetti C, Spertini L, Parpinel M, Gnagnarella P, Lagiou P, Negri E, Franceschi S, Montella M, Peterson J, Dwyer J, Giacosa A and La Vecchia C: Flavonoids and breast cancer risk in Italy. Cancer Epidemiol Biomarkers Prev 14: 805-808, 2005. (Pubitemid 40478539)
14. Mitchell JH, Gardner PT, McPhail DB, Morrice PC, Collins AR and Duthie GG: Antioxidant efficacy of phytoestrogens in chemical and biological model systems. Arch Biochem Biophys 360: 142-148, 1998.
15. Rüfer CE and Kulling SE: Antioxidant activity of isoflavones and their major metabolites using different in vitro assays. J Agric Food Chem 54: 2926-2931, 2006.
16. Yuan JP, Wang JH and Liu XL: Metabolism of dietary soy isoflavones to equol by human intestinal microflora - implications for health. Mol Nutr Food Res 51: 765-781, 2007.
17. Garreau B, Vallette G, Adlercreutz H, Wähälä K, Mäkelä T, Benassayag C and Nunez EA: Phytoestrogens: new ligands for rat and human alpha-fetoprotein. Biochim Biophys Acta 1094: 339-345, 1991.
18. Setchell KD, Brown NM and Lydeking-Olsen E: The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 132: 3577-3584, 2002.
19. Cos P, De Bruyne T, Apers S, Vanden Berghe D, Pieters L and Vlietinck AJ: Phytoestrogens: recent developments. Planta Med 69: 589-599, 2003.
20. Dubey RK, Gillespie DG, Imthurn B, Rosselli M, Jackson EK and Keller PJ: Phytoestrogens inhibit growth and MAP kinase activity in human aortic smooth muscle cells. Hypertension 33: 177-182, 1999. (Pubitemid 29065656)
21. Hedlund TE, van Bokhoven A, Johannes WU, Nordeen SK and Ogden LG: Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. Prostate 66: 557-566, 2006.
22. Ogle TF, George P and Dai D: Progesterone and estrogen regulation of rat decidual cell expression of proliferating cell nuclear antigen. Biol Reprod 59: 444-450, 1998. (Pubitemid 28354889)
23. Ju YH, Fultz J, Allred KF, Doerge DR and Helferich WG: Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis 27: 856-863, 2006.
24. Sathyamoorthy N and Wang TT: Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells. Eur J Cancer 33: 2384-2389, 1997. (Pubitemid 28129181)
25. Matsumura A, Ghosh A, Pope GS and Darbre PD: Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol 94: 431-443, 2005. (Pubitemid 40616404)
26. Morla AO, Draetta G, Beach D and Wang JY: Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell 58: 193-203, 1989. (Pubitemid 19180091)
27. Jessus C and Beach D: Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B. Cell 68: 323-332, 1992.
28. Reiners JJ, Clift R and Mathieu P: Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor. Carcinogenesis 20: 1561-1566, 1999. (Pubitemid 29385445)
29. Choi SU, Ryu SY, Yoon SK, Jung NP, Park SH, Kim KH, Choi EJ and Lee CO: Effects of flavonoids on the growth and cell cycle of cancer cells. 1: Anticancer Res 19: 5229-5233, 1999. (Pubitemid 30103353)
30. Singh RP and Agarwal R: Natural flavonoids targeting deregulated cell cycle progression in cancer cells. Curr Drug Targets 7: 345-354, 2006. (Pubitemid 43744850)
31. Walle T, Ta N, Kawamori T, Wen X, Tsuji PA and Walle UK: Cancer chemopreventive properties of orally bioavailable flavonoids - methylated versus unmethylated flavones. Biochem Pharmacol 73: 1288-1296, 2007. (Pubitemid 46452585)
32. Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999.
33. Nakayama KI, Hatakeyama S and Nakayama K: Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1. Biochem Biophys Res Commun 282: 853-860, 2001. (Pubitemid 32924572)
34. Porter LA, Kong-Beltran M and Donoghue DJ: Spy1 interacts with p27Kip1 to allow G1/S progression. Mol Biol Cell 14: 3664-3674, 2003.
35. Agarwal ML, Agarwal A, Taylor WR and Stark GR: p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 92: 8493-8497, 1995.
36. Park M, Chae HD, Yun J, Jung M, Kim YS, Kim SH, Han MH and Shin DY: Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Cancer Res 60: 542-545, 2000. (Pubitemid 30094547)
37. Lepik D, Jaks V, Kadaja L, Värv S and Maimets T: Electroporation and carrier DNA cause p53 activation, cell cycle arrest, and apoptosis. Anal Biochem 318: 52-59, 2003. (Pubitemid 36637014)
38. Oakes SA, Lin SS and Bassik MC: The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr Mol Med 6: 99-109, 2006.
39. van Delft MF and Huang DC: How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 16: 203-213, 2006. (Pubitemid 43247978)