Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes

Molecular Pharmaceutics

Volumn 11, Issue 8, 2014, Pages 2631-2639

  Lächelt, Ulrich ^a,b   Wittmann, Valentin ^a   Müller, Katharina ^a   Edinger, Daniel ^a   Kos, Petra ^a   Höhn, Miriam ^a   Wagner, Ernst ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b NANOSYSTEMS INITIATIVE MUNICH NIM   (Germany)

Author keywords

drug delivery; methotrexate; poly(I:C); polymer conjugates; tumor targeting

Indexed keywords

AMIDE; DIHYDROFOLATE REDUCTASE; FOLATE RECEPTOR; FOLIC ACID ANTAGONIST; GLUTAMIC ACID; LIGAND; MACROGOL; METHOTREXATE; NUCLEIC ACID; POLYGLUTAMIC ACID; POLYINOSINIC POLYCYTIDYLIC ACID; ANTINEOPLASTIC AGENT; GLUTAMINE; PEPTIDE; POLYGLUTAMINE;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER THERAPY; COMPLEX FORMATION; CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; KB CELL LINE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CELL LINE; CHEMISTRY; DRUG DESIGN; FEMALE; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; METABOLISM; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; DRUG DESIGN; FEMALE; FOLIC ACID ANTAGONISTS; GLUTAMINE; HUMANS; LIGANDS; METHOTREXATE; MICROSCOPY, FLUORESCENCE; PEPTIDES; POLY I-C; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRANSFECTION; UTERINE CERVICAL NEOPLASMS;

EID: 84905459950     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500017u     Document Type: Article

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