Human cathelicidin production by the cervix

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Frew, Lorraine ^a   Makieva, Sofia ^a   McKinlay, Andrew T M ^a   McHugh, Brian J ^b   Doust, Ann ^a   Norman, Jane E ^a   Davidson, Donald J ^b   Stock, Sarah J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,25 HYDROXYVITAMIN D3; CALCIFEDIOL; CATHELICIDIN; INTERLEUKIN 8; UNCLASSIFIED DRUG; VITAMIN D; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; CYTOKINE; TOLL LIKE RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EPITHELIUM CELL; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UPREGULATION; UTERINE CERVIX EPITHELIUM; UTERINE CERVIX MUCUS; VAGINA FLORA; VAGINITIS; VITAMIN BLOOD LEVEL; AGONISTS; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; CELL LINE; COHORT ANALYSIS; DRUG EFFECTS; METABOLISM; PREGNANCY; SECRETION (PROCESS); UTERINE CERVIX;

ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; CALCIFEDIOL; CELL LINE; CERVIX UTERI; COHORT STUDIES; CYTOKINES; EPITHELIAL CELLS; FEMALE; HUMANS; INTERLEUKIN-8; PREGNANCY; TOLL-LIKE RECEPTORS; VAGINOSIS, BACTERIAL; VITAMIN D;

EID: 84905455172     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103434     Document Type: Article

References (52)

1. Zanetti M (2004) Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol 75: 39-48.
2. Beaumont PE, Li H-N, Davidson DJ (2013) LL-37: an immunomodulatory antimicrobial host defence peptide. Springer Bassel
3. Nell MJ, Sandra Tjabringa G, Vonk MJ, Hiemstra PS, Grote JJ (2004) Bacterial products increase expression of the human cathelicidin hCAP-18/LL-37 in cultured human sinus epithelial cells. FEMS Immunology & Medical Microbiology 42: 225-231. (Pubitemid 39208551)
4. Erdag G, Morgan JR (2002) Interleukin-1alpha and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts. Ann Surg 235: 113-124. (Pubitemid 34062407)
5. Wang T-T, Nestel FP, Bourdeau V, Nagai Y, Wang Q, et al. (2004) Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression. The Journal of Immunology 173: 2909-2912. (Pubitemid 39141992)
6. Gombart AF, Borregaard N, Koeffler HP (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. The FASEB Journal 19: 1067-1077. (Pubitemid 40946432)
7. Levinson P, Choi RY, Cole AL, Hirbod T, Rhedin S, et al. (2012) HIV-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in HIV-serodiscordant relationships. PLoS One 7: e31996.
8. Frohm Nilsson M, Sandstedt B, Sorensen O, Weber G, Borregaard N, et al. (1999) The Human Cationic Antimicrobial Protein (hCAP18), a Peptide Antibiotic, Is Widely Expressed in Human Squamous Epithelia and Colocalizes with Interleukin-6. Infect Immun 67: 2561-2566. (Pubitemid 29200519)
9. Levinson P, Kaul R, Kimani J, Ngugi E, Moses S, et al. (2009) Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. Aids 23: 309-317.
10. Kaewsrichan J, Peeyananjarassri K, Kongprasertkit J (2006) Selection and identification of anaerobic lactobacilli producing inhibitory compounds against vaginal pathogens. FEMS Immunology & Medical Microbiology 48: 75-83. (Pubitemid 44379222)
11. Stock SJ, Duthie L, Tremaine T, Calder AA, Kelly RW, et al. (2009) Elafin (SKALP/Trappin-2/proteinase inhibitor-3) Is Produced by the Cervix in Pregnancy and Cervicovaginal Levels Are Diminished in Bacterial Vaginosis. Reproductive Sciences 16: 1125-1134.
12. Mitchell C, Gottsch ML, Liu C, Fredricks DN, Nelson DB (2013) Associations between vaginal bacteria and levels of vaginal defensins in pregnant women. Am J Obstet Gynecol 208: 132.e131-137.
13. Racicot K, Cardenas I, Wunsche V, Aldo P, Guller S, et al. (2013) Viral infection of the pregnant cervix predisposes to ascending bacterial infection. J Immunol 191: 934-941.
14. Nugent RP, Krohn MA, Hillier SL (1991) Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 29: 297-301.
15. Johnson DD, Wagner CL, Hulsey TC, McNeil RB, Ebeling M, et al. (2011) Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol 28: 7-12.
16. Valore EV, Wiley DJ, Ganz T (2006) Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infection and Immunity 74: 5693-5702. (Pubitemid 44484553)
17. McAree T, Jacobs B, Manickavasagar T, Sivalokanathan S, Brennan L, et al. (2013) Vitamin D deficiency in pregnancy - still a public health issue. Matern Child Nutr 9: 23-30.
18. Liu Q, Liu J, Roschmann KIL, van Egmond D, Golebski K, et al. (2013) Histone deacetylase inhibitors up-regulate LL-37 expression independent of tolllike receptor mediated signalling in airway epithelial cells. J Inflamm-Lond 10: 6.
19. Ruiz-Gonzalez V, Cancino-Diaz JC, Rodriguez-Martinez S, Cancino-Diaz ME (2009) Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin-13. International Journal of Dermatology 48: 846-854.
20. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, et al. (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311: 1770-1773.
21. Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, et al. (2008) IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol 181: 7115-7120.
22. Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, et al. (2009) Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One 4: e5810.
23. Hansdottir S, Monick MM, Lovan N, Powers L, Gerke A, et al. (2010) Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol 184: 965-974.
24. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G (2007) Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25- dihydroxyvitamin D(3). J Cyst Fibros 6: 403-410. (Pubitemid 350028703)
25. National Collaborating Centre for Ws and Children's H (2008) National Institute for Health and Clinical Excellence: Guidance. Antenatal Care: Routine care for the healthy pregnant woman. London: RCOG Press National Collaborating Centre for Women's and Children's Health.
26. Haggarty P, Campbell DM, Knox S, Horgan GW, Hoad G, et al. (2013) Vitamin D in pregnancy at high latitude in Scotland. Br J Nutr 109: 898-905.
27. Toher C, Lindsay K, McKenna M, Kilbane M, Curran S, et al. (2013) Relationship between vitamin D knowledge and 25-hydroxyvitamin D levels amongst pregnant women. J Hum Nutr Diet.
28. Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, et al. (2012) Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults. BMC Res Notes 5: 575.
29. Bhan I, Camargo CA Jr, Wenger J, Ricciardi C, Ye J, et al. (2011) Circulating levels of 25-hydroxyvitamin D and human cathelicidin in healthy adults. J Allergy Clin Immunol 127: 1302-1304.e1301.
30. Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, et al. (2009) Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 7: 28.
31. Gombart AF, Bhan I, Borregaard N, Tamez H, Camargo CA Jr, et al. (2009) Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. Clin Infect Dis 48: 418-424.
32. Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, et al. (2009) Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol 182: 4289-4295.
33. Mandic Havelka A, Yektaei-Karin E, Hultenby K, Sørensen OE, Lundahl J, et al. (2010) Maternal plasma level of antimicrobial peptide LL37 is a major determinant factor of neonatal plasma LL37 level. Acta Pædiatrica 99: 836-841.
34. Hertting O, Holm A, Luthje P, Brauner H, Dyrdak R, et al. (2010) Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS One 5: e15580.
35. Schaller-Bals S, Schulze A, Bals R (2002) Increased Levels of Antimicrobial Peptides in Tracheal Aspirates of Newborn Infants during Infection. Am J Respir Crit Care Med 165: 992-995. (Pubitemid 34774670)
36. Yang D, Chen Q, Schmidt AP, Anderson GM, Wang JM, et al. (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192: 1069-1074.
37. Elssner A, Duncan M, Gavrilin M, Wewers MD (2004) A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol 172: 4987-4994. (Pubitemid 38456425)
38. Tjabringa GS, Aarbiou J, Ninaber DK, Drijfhout JW, Sorensen OE, et al. (2003) The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 171: 6690-6696. (Pubitemid 37532101)
39. Wantha S, Alard JE, Megens RT, van der Does AM, Doring Y, et al. (2013) Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res 112: 792-801.
40. Carretero M, Escamez MJ, Garcia M, Duarte B, Holguin A, et al. (2008) In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37. J Invest Dermatol 128: 223-236. (Pubitemid 350249392)
41. Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, et al. (2003) An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 111: 1665-1672. (Pubitemid 38057748)
42. Nagaoka I, Tamura H, Hirata M (2006) An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J Immunol 176: 3044-3052.
43. Barlow PG, Li Y, Wilkinson TS, Bowdish DM, Lau YE, et al. (2006) The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol 80: 509-520. (Pubitemid 44835784)
44. Coffelt SB, Tomchuck SL, Zwezdaryk KJ, Danka ES, Scandurro AB (2009) Leucine leucine-37 uses formyl peptide receptor-like 1 to activate signal transduction pathways, stimulate oncogenic gene expression, and enhance the invasiveness of ovarian cancer cells. Mol Cancer Res 7: 907-915.
45. Kahlenberg JM, Carmona-Rivera C, Smith CK, Kaplan MJ (2013) Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. J Immunol 190: 1217-1226.
46. Nagaoka I, Tamura H, Hirata M (2006) An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7. The Journal of Immunology 176: 3044-3052.
47. Byfield FJ, Wen Q, Leszczynska K, Kulakowska A, Namiot Z, et al. (2011) Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability. Am J Physiol Cell Physiol 300: C105-112.
48. Tomasinsig L, Pizzirani C, Skerlavaj B, Pellegatti P, Gulinelli S, et al. (2008) The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner. J Biol Chem 283: 30471-30481.
49. Montreekachon P, Chotjumlong P, Bolscher JG, Nazmi K, Reutrakul V, et al. (2011) Involvement of P2X(7) purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts. J Periodontal Res 46: 327-337.
50. Lau YE, Rozek A, Scott MG, Goosney DL, Davidson DJ, et al. (2005) Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun 73: 583-591. (Pubitemid 40041153)
51. Davidson DJ, Currie AJ, Reid GS, Bowdish DM, MacDonald KL, et al. (2004) The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J Immunol 172: 1146-1156. (Pubitemid 38113775)
52. Mookherjee N, Lippert DN, Hamill P, Falsafi R, Nijnik A, et al. (2009) Intracellular receptor for human host defense peptide LL-37 in monocytes. J Immunol 183: 2688-2696.