Interleukin-1α and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts

Annals of Surgery

Volumn 235, Issue 1, 2002, Pages 113-124

  Erdag, Gulsun ^a   Morgan, Jeffrey R ^a  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LYSOZYME; PHOSPHOLIPASE A2; ANTIMICROBIAL CATIONIC PEPTIDE; INTERLEUKIN 1; MESSENGER RNA; RNA;

ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BURN; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; INFECTION RISK; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS; ANIMAL; BACTERIAL INFECTION; BACTERIUM; CADAVER; COMPARATIVE STUDY; CULTURE MEDIUM; DRUG EFFECT; IMMUNOLOGY; ISOLATION AND PURIFICATION; NUDE MOUSE; STATISTICAL ANALYSIS; TIME; TRANSPLANTATION; WOUND INFECTION;

ANIMAL; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL INFECTIONS; BURNS; CADAVER; CELLS, CULTURED; COMPARATIVE STUDY; CULTURE MEDIA; DATA INTERPRETATION, STATISTICAL; HUMAN; INTERLEUKIN-1; INTERLEUKIN-6; KERATINOCYTES; MALE; MICE; MICE, NUDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; WOUND INFECTION;

EID: 0036006682     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-200201000-00015     Document Type: Article

References (39)

1. Cultured skin for massive burns: A prospective, controlled trial
2. Cultured skin substitutes: A review
3. Biologic attachment, growth, and differentiation of cultured human epidermal keratinocytes on a graftable collagen and chondroitin-6-sulfate substrate
4. Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane, and rete ridge formation of transplanted composite skin grafts
5. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness
6. Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate
7. Permanent coverage of large burn wounds with autologous cultured human epithelium
8. Cultured epidermis for the coverage of massive burn wounds
9. Cultured autologous epithelium in patients with burns of ninety percent or more of the body surface
10. Cost-efficacy of cultured epidermal autografts in massive pediatric burns
11. Cytotoxicity testing of topical anti-microbial agents on human keratinocytes and fibroblasts for cultured skin grafts
12. Selection of topical anti-microbial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and anti-microbial activity
13. Cytotoxicity tests for anti-microbial agents using cultured skin substitutes fixed at interface of air and culture medium
14. Cytotoxicity to cultured human keratinocytes of topical anti-microbial agents
15. Innate immunity
16. Peptide antibiotics and their role in innate immunity
17. Molecular mechanisms of innate immunity
18. Defensins and host defense
19. Anti-microbial peptides: An emerging concept in cutaneous biology
20. Identification of two secreted phospholipase A2 in human epidermis
21. De novo synthesis of lysozyme by human epidermal cells
22. Expression of natural peptide antibiotics in human skin
23. A peptide antibiotic from human skin
24. The expression of the gene coding for the anti-bacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
25. Antileukoprotease in human skin: An antibiotic peptide constitutively produced by keratinocytes
26. Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes
27. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells
28. Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice
29. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C
30. p15s (15-kD anti-microbial proteins) are stored in the secondary granules of rabbit granulocytes: Implications for anti-bacterial synergy with the bacterial/permeability-increasing protein in inflammatory fluids
31. Levels of intracellular protein and lysozyme in normal human nasal and polyp epithelium
32. Methods for cultivation of keratinocytes with an air-liquid interface
33. Mechanical deformation promotes secretion of IL-1α and IL-1 receptor antagonist
34. Production of IL-6 by keratinocytes: Implications for epidermal inflammation and immunity
35. Interleukin-1 and other human keratinocyte cytokines: Molecular and functional characterization
36. Interleukin-1α stimulates keratinocyte migration through an epidermal growth factor/transforming growth factor-α-independent pathway
37. Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (Type 1) on epidermal keratinocytes. Evidence that IL-1 inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease
38. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
39. Interleukin-1 and cutaneous inflammation: A crucial link between innate and acquired immunity