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Volumn 300, Issue 1, 2011, Pages

Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability

Author keywords

Cytoskeleton; Endothelium

Indexed keywords

ACTIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; F ACTIN; PURINERGIC P2X7 RECEPTOR; SPHINGOSINE 1 PHOSPHATE;

EID: 78651363517     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00158.2010     Document Type: Article
Times cited : (36)

References (38)
  • 1
    • 0032482980 scopus 로고    scopus 로고
    • The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
    • Bals R, Wang X, Zasloff M, Wilson JM. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA 95: 9541-9546, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9541-9546
    • Bals, R.1    Wang, X.2    Zasloff, M.3    Wilson, J.M.4
  • 2
    • 44649135256 scopus 로고    scopus 로고
    • Endogenous antimicrobial peptide LL-37 induces human vasodilatation
    • Berkestedt I, Nelson A, Bodelsson M. Endogenous antimicrobial peptide LL-37 induces human vasodilatation. Br J Anaesth 100: 803-809, 2008.
    • (2008) Br J Anaesth , vol.100 , pp. 803-809
    • Berkestedt, I.1    Nelson, A.2    Bodelsson, M.3
  • 3
    • 59849120325 scopus 로고    scopus 로고
    • Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: Atomic force microscopy force mapping of pulmonary endothelial monolayer
    • Birukova AA, Arce FT, Moldobaeva N, Dudek SM, Garcia JG, Lal R, Birukov KG. Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer. Nanomedicine 5: 30-41, 2009.
    • (2009) Nanomedicine , vol.5 , pp. 30-41
    • Birukova, A.A.1    Arce, F.T.2    Moldobaeva, N.3    Dudek, S.M.4    Garcia, J.G.5    Lal, R.6    Birukov, K.G.7
  • 7
    • 2142825687 scopus 로고    scopus 로고
    • Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin
    • Bucki R, Pastore JJ, Randhawa P, Vegners R, Weiner DJ, Janmey PA. Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin. Antimicrob Agents Chemother 48: 1526-1533, 2004.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1526-1533
    • Bucki, R.1    Pastore, J.J.2    Randhawa, P.3    Vegners, R.4    Weiner, D.J.5    Janmey, P.A.6
  • 8
    • 34548131220 scopus 로고    scopus 로고
    • Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA or F-actin and its activity in cystic fibrosis sputum
    • Bucki R, Sostarecz AG, Byfield FJ, Savage PB, Janmey PA. Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA or F-actin and its activity in cystic fibrosis sputum. J Antimicrob Chemother 60: 535-545, 2007.
    • (2007) J Antimicrob Chemother , vol.60 , pp. 535-545
    • Bucki, R.1    Sostarecz, A.G.2    Byfield, F.J.3    Savage, P.B.4    Janmey, P.A.5
  • 9
    • 1642405248 scopus 로고    scopus 로고
    • Beta-defensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis
    • Chen CI, Schaller-Bals S, Paul KP, Wahn U, Bals R. Beta-defensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis. J Cyst Fibros 3: 45-50, 2004.
    • (2004) J Cyst Fibros , vol.3 , pp. 45-50
    • Chen, C.I.1    Schaller-Bals, S.2    Paul, K.P.3    Wahn, U.4    Bals, R.5
  • 10
    • 0034596945 scopus 로고    scopus 로고
    • LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    • De Y, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192: 1069-1074, 2000.
    • (2000) J Exp Med , vol.192 , pp. 1069-1074
    • De, Y.1    Chen, Q.2    Schmidt, A.P.3    Anderson, G.M.4    Wang, J.M.5    Wooters, J.6    Oppenheim, J.J.7    Chertov, O.8
  • 11
    • 23044472373 scopus 로고    scopus 로고
    • Activity of the de novo engineered antimicrobial peptide WLBU2 against Pseudomonas aeruginosa in human serum and whole blood: Implications for systemic applications
    • Deslouches B, Islam K, Craigo JK, Paranjape SM, Montelaro RC, Mietzner TA. Activity of the de novo engineered antimicrobial peptide WLBU2 against Pseudomonas aeruginosa in human serum and whole blood: implications for systemic applications. Antimicrob Agents Chemother 49: 3208-3216, 2005.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3208-3216
    • Deslouches, B.1    Islam, K.2    Craigo, J.K.3    Paranjape, S.M.4    Montelaro, R.C.5    Mietzner, T.A.6
  • 12
    • 1842581655 scopus 로고    scopus 로고
    • A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release
    • Elssner A, Duncan M, Gavrilin M, Wewers MD. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol 172: 4987-4994, 2004.
    • (2004) J Immunol , vol.172 , pp. 4987-4994
    • Elssner, A.1    Duncan, M.2    Gavrilin, M.3    Wewers, M.D.4
  • 16
    • 0032404028 scopus 로고    scopus 로고
    • Enhancement of phosphoinositide 3-kinase (PI 3-kinase) activity by membrane curvature and inositol-phospholipid-binding peptides
    • Hubner S, Couvillon AD, Kas JA, Bankaitis VA, Vegners R, Carpenter CL, Janmey PA. Enhancement of phosphoinositide 3-kinase (PI 3-kinase) activity by membrane curvature and inositol-phospholipid-binding peptides. Eur J Biochem 258: 846-853, 1998.
    • (1998) Eur J Biochem , vol.258 , pp. 846-853
    • Hubner, S.1    Couvillon, A.D.2    Kas, J.A.3    Bankaitis, V.A.4    Vegners, R.5    Carpenter, C.L.6    Janmey, P.A.7
  • 18
    • 0032456204 scopus 로고    scopus 로고
    • Characterization of the polymorphonuclear leukocyte-induced vasoconstriction in isolated human umbilical veins
    • Kerr SW, Yu R, Stearns CD, Haynes NA, Winquist RJ. Characterization of the polymorphonuclear leukocyte-induced vasoconstriction in isolated human umbilical veins. J Pharmacol Exp Ther 287: 640-647, 1998.
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 640-647
    • Kerr, S.W.1    Yu, R.2    Stearns, C.D.3    Haynes, N.A.4    Winquist, R.J.5
  • 19
    • 70349630154 scopus 로고    scopus 로고
    • Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice
    • Leszczynska K, Namiot A, Fein DE, Wen Q, Namiot Z, Savage PB, Diamond S, Janmey PA, Bucki R. Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice. BMC Microbiol 9: 187, 2009.
    • (2009) BMC Microbiol , vol.9 , pp. 187
    • Leszczynska, K.1    Namiot, A.2    Fein, D.E.3    Wen, Q.4    Namiot, Z.5    Savage, P.B.6    Diamond, S.7    Janmey, P.A.8    Bucki, R.9
  • 20
    • 33847036735 scopus 로고    scopus 로고
    • Soft biological matherials and their impact on cell function
    • Levental I, Georges PC, Janmey PA. Soft biological matherials and their impact on cell function. Soft Matter 1: 299-306, 2007.
    • (2007) Soft Matter , vol.1 , pp. 299-306
    • Levental, I.1    Georges, P.C.2    Janmey, P.A.3
  • 21
    • 70350566135 scopus 로고    scopus 로고
    • Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury
    • Liu X, Wu W, Li Q, Huang X, Chen B, Du J, Zhao K, Huang Q. Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury. Burns 35: 1171-1179, 2009.
    • (2009) Burns , vol.35 , pp. 1171-1179
    • Liu, X.1    Wu, W.2    Li, Q.3    Huang, X.4    Chen, B.5    Du, J.6    Zhao, K.7    Huang, Q.8
  • 22
  • 23
    • 33644839612 scopus 로고    scopus 로고
    • Signaling mechanisms regulating endothelial permeability
    • Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Rev 86: 279-367, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 279-367
    • Mehta, D.1    Malik, A.B.2
  • 25
    • 1342282224 scopus 로고    scopus 로고
    • Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense
    • Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL. Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. J Immunol 172: 3070-3077, 2004.
    • (2004) J Immunol , vol.172 , pp. 3070-3077
    • Murakami, M.1    Lopez-Garcia, B.2    Braff, M.3    Dorschner, R.A.4    Gallo, R.L.5
  • 26
    • 33644511380 scopus 로고    scopus 로고
    • An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7
    • Nagaoka I, Tamura H, Hirata M. An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J Immunol 176: 3044-3052, 2006.
    • (2006) J Immunol , vol.176 , pp. 3044-3052
    • Nagaoka, I.1    Tamura, H.2    Hirata, M.3
  • 27
    • 42449110795 scopus 로고    scopus 로고
    • Regulation of cell-cell adhesion by the cadherin-catenin complex
    • Nelson WJ. Regulation of cell-cell adhesion by the cadherin-catenin complex. Biochem Soc Trans 36: 149-155, 2008.
    • (2008) Biochem Soc Trans , vol.36 , pp. 149-155
    • Nelson, W.J.1
  • 28
    • 0035058454 scopus 로고    scopus 로고
    • Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
    • Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur J Immunol 31: 1066-1075, 2001.
    • (2001) Eur J Immunol , vol.31 , pp. 1066-1075
    • Niyonsaba, F.1    Someya, A.2    Hirata, M.3    Ogawa, H.4    Nagaoka, I.5
  • 30
    • 26444551684 scopus 로고    scopus 로고
    • Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin
    • Singleton PA, Dudek SM, Chiang ET, Garcia JG. Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin. FASEB J 19: 1646-1656, 2005.
    • (2005) FASEB J , vol.19 , pp. 1646-1656
    • Singleton, P.A.1    Dudek, S.M.2    Chiang, E.T.3    Garcia, J.G.4
  • 31
    • 0035877995 scopus 로고    scopus 로고
    • Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3
    • Sorensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS, Borregaard N. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97: 3951-3959, 2001.
    • (2001) Blood , vol.97 , pp. 3951-3959
    • Sorensen, O.E.1    Follin, P.2    Johnsen, A.H.3    Calafat, J.4    Tjabringa, G.S.5    Hiemstra, P.S.6    Borregaard, N.7
  • 32
    • 0346996865 scopus 로고    scopus 로고
    • The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor
    • Tjabringa GS, Aarbiou J, Ninaber DK, Drijfhout JW, Sorensen OE, Borregaard N, Rabe KF, Hiemstra PS. The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 171: 6690-6696, 2003.
    • (2003) J Immunol , vol.171 , pp. 6690-6696
    • Tjabringa, G.S.1    Aarbiou, J.2    Ninaber, D.K.3    Drijfhout, J.W.4    Sorensen, O.E.5    Borregaard, N.6    Rabe, K.F.7    Hiemstra, P.S.8
  • 36
    • 0032509199 scopus 로고    scopus 로고
    • Apolipoprotein A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37
    • Wang Y, Agerberth B, Lothgren A, Almstedt A, Johansson J. Apolipoprotein A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37. J Biol Chem 273: 33115-33118, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 33115-33118
    • Wang, Y.1    Agerberth, B.2    Lothgren, A.3    Almstedt, A.4    Johansson, J.5
  • 38
    • 0038312912 scopus 로고    scopus 로고
    • The antimicrobial activity of the cathelicidin LL-37 is inhibited by F-actin bundles and restored by gelsolin
    • Weiner DJ, Bucki R, Janmey PA. The antimicrobial activity of the cathelicidin LL-37 is inhibited by F-actin bundles and restored by gelsolin. Am J Respir Cell Mol Biol 28: 738-745, 2003.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 738-745
    • Weiner, D.J.1    Bucki, R.2    Janmey, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.