Elafin (SKALP/Trappin-2/proteinase inhibitor-3) is produced by the cervix in pregnancy and cervicovaginal levels are diminished in bacterial vaginosis

Reproductive Sciences

Volumn 16, Issue 12, 2009, Pages 1125-1134

  Stock, Sarah J ^a   Duthie, Leanne ^a   Tremaine, Tina ^a   Calder, Andrew A ^a   Kelly, Rodney W ^b,c   Riley, Simon C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Bacterial vaginosis.; Cervix; Elafin; Pregnancy; Whey 4 disulphide core domain

Indexed keywords

ELAFIN; INTERLEUKIN 1BETA; INTERLEUKIN 8;

ADULT; ARTICLE; BACTERIAL FLORA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PREGNANCY; PRIORITY JOURNAL; UTERINE CERVIX EPITHELIUM; UTERINE CERVIX MUCUS; UTERINE ENDOCERVIX; VAGINA EPITHELIUM; VAGINA SECRETION; VAGINITIS;

ADULT; CELL LINE; CERVIX UTERI; DOWN-REGULATION; ELAFIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; INTERLEUKIN-8; MUCOUS MEMBRANE; PREGNANCY; PREGNANCY TRIMESTER, FIRST; RNA, MESSENGER; VAGINA; VAGINOSIS, BACTERIAL;

EID: 70450205250     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719109341998     Document Type: Article

References (41)

1. Schalkwijk J., Wiedow O., Hirose S. The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Biochem J. 1999 ; 340 (pt 3). 569-577.
2. Sallenave JM, Silva A. Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. Am J Respir Cell Mol Biol. 1993 ; 8 (4). 439-445.
3. Pfundt R., van Ruissen F., van Vlijmen-Willems IM, et al. Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. J Clin Invest. 1996 ; 98 (6). 1389-1399.
4. Mihaila A., Tremblay GM Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor. Z Naturforsch [C]. 2001 ; 56 (3-4). 291-297.
5. Williams SE, Brown TI, Roghanian A., Sallenave JM SLPI and elafin: one glove, many fingers. Clin Sci (Lond). 2006 ; 110: 21-35.
6. Sallenave JM, Shulmann J., Crossley J., Jordana M., Gauldie J. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol. 1994 ; 11 (6). 733-741.
7. Tanaka N., Fujioka A., Tajima S., Ishibashi A., Hirose S. Elafin is induced in epidermis in skin disorders with dermal neutrophilic infiltration: interleukin-1 beta and tumour necrosis factor-alpha stimulate its secretion in vitro. Br J Dermatol. 2000 ; 143 (4). 728-732.
8. Simpson AJ, Maxwell AI, Govan JR, Haslett C., Sallenave JM Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens. FEBS Lett. 1999 ; 452 (3). 309-313.
9. Baranger K., Zani ML, Chandenier J., Dallet-Choisy S., Moreau T. The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function. Febs J. 2008 ; 275 (9). 2008-2020.
10. Simpson AJ, Wallace WA, Marsden ME, et al. Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. J Immunol. 2001 ; 167 (3). 1778-1786.
11. Sallenave JM Antimicrobial activity of antiproteinases. Biochem Soc Trans. 2002 ; 30 (2). 111-115.
12. Roghanian A., Williams SE, Sheldrake TA, et al. The antimicrobial/ elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity. Am J Respir Cell Mol Biol. 2006 ; 34 (5). 634-642.
13. Fleming DC, King AE, Williams AR, Critchley HO, Kelly RW Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium. Fertil Steril. 2003 ; 79 (4). 856-863.
14. King AE, Critchley HO, Kelly RW Innate immune defences in the human endometrium. Reprod Biol Endocrinol. 2003 ; 1: 116.
15. King AE, Critchley HO, Sallenave JM, Kelly RW Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation. J Clin Endocrinol Metab. 2003 ; 88 (9). 4426-4431.
16. King AE, Paltoo A., Kelly RW, Sallenave JM, Bocking AD, Challis JR Expression of natural antimicrobials by human placenta and fetal membranes. Placenta. 2007 ; 28 (2-3). 161-169.
17. Tromp G., Kuivaniemi H., Romero R., et al. Genome-wide expression profiling of fetal membranes reveals a deficient expression of proteinase inhibitor 3 in premature rupture of membranes. Am J Obstet Gynecol. 2004 ; 191 (4). 1331-1338.
18. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008 ; 371 (9606). 75-84.
19. Osman I., Young A., Ledingham MA, et al. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod. 2003 ; 9 (1). 41-45.
20. Kelly RW Inflammatory mediators and cervical ripening. J Reprod Immunol. 2002 ; 57 (1-2). 217-224.
21. Leitich H., Bodner-Adler B., Brunbauer M., Kaider A., Egarter C., Husslein P. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol. 2003 ; 189 (1). 139-147.
22. Wilkinson D., Ndovela N., Kharsany A., Connolly C., Sturm AW Tampon sampling for diagnosis of bacterial vaginosis: a potentially useful way to detect genital infections ? J Clin Microbiol. 1997 ; 35 (9). 2408-2409.
23. Sturm PD, Moodley P., Nzimande G., Balkistan R., Connolly C., Sturm AW Diagnosis of bacterial vaginosis on self-collected vaginal tampon specimens. Int J STD AIDS. 2002 ; 13 (8). 559-563.
24. Nugent RP, Krohn MA, Hillier SL Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991 ; 29 (2). 297-301.
25. Valore EV, Wiley DJ, Ganz T. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun. 2006 ; 74 (10). 5693-5702.
26. Imseis HM, Greig PC, Livengood CH 3rd, Shunior E., Durda P., Erikson M. Characterization of the inflammatory cytokines in the vagina during pregnancy and labor and with bacterial vaginosis. J Soc Gynecol Investig. 1997 ; 4 (2). 90-94.
27. Mattsby-Baltzer I., Platz-Christensen JJ, Hosseini N., Rosen P. IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis. Acta Obstet Gynecol Scand. 1998 ; 77 (7). 701-706.
28. Cauci S., Guaschino S., De Aloysio D., et al. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod. 2003 ; 9 (1). 53-58.
29. Spandorfer SD, Neuer A., Giraldo PC, Rosenwaks Z., Witkin SS Relationship of abnormal vaginal flora, pro-inflammatory cytokines and idiopathic infertility in women undergoing IVF. J Reprod Med. 2001 ; 46 (9). 806-810.
30. Hedges SR, Barrientes F., Desmond RA, Schwebke JR Local and systemic cytokine levels in relation to changes in vaginal flora. J Infect Dis. 2006 ; 193 (4). 556-562.
31. Basso B., Gimenez F., Lopez C. IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections. Infect Dis Obstet Gynecol. 2005 ; 13 (4). 207-211.
32. Draper DL, Landers DV, Krohn MA, Hillier SL, Wiesenfeld HC, Heine RP Levels of vaginal secretory leukocyte protease inhibitor are decreased in women with lower reproductive tract infections. Am J Obstet Gynecol. 2000 ; 183 (5). 1243-1248.
33. Fichorova RN, Rheinwald JG, Anderson DJ Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod. 1997 ; 57: 847-855.
34. Valore EV, Park CH, Igreti SL, Ganz T. Antimicrobial components of vaginal fluid. Am J Obstet Gynecol. 2002 ; 187 (3). 561-568.
35. Krisanaprakornkit S., Kimball JR, Weinberg A., Darveau RP, Bainbridge BW, Dale BA Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun. 2000 ; 68 (5). 2907-2915.
36. Chowdhury MA, Kuivaniemi H., Romero R., Edwin S., Chaiworapongsa T., Tromp G. Identification of novel functional sequence variants in the gene for peptidase inhibitor 3. BMC Med Genet. 2006 ; 7: 49.
37. Balu RB, Savitz DA, Ananth CV, et al. Bacterial vaginosis and vaginal fluid defensins during pregnancy. Am J Obstet Gynecol. 2002 ; 187 (5). 1267-1271.
38. Zaidi SH, You XM, Ciura S., ́Blenes S., Husain M., Rabinovitch M. Suppressed smooth muscle proliferation and inflammatory cell invasion after arterial injury in elafinoverexpressing mice. J Clin Invest. 2000 ; 105 (12). 1687-1695.
39. Vachon E., Bourbonnais Y., Bingle CD, Rowe SJ, Janelle MF, Tremblay GM Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation. Biol Chem. 2002 ; 383 (7-8). 1249-1256.
40. Henriksen PA, Devitt A., Kotelevtsev Y., Sallenave JM Gene delivery of the elastase inhibitor elafin protects macrophages from neutrophil elastase-mediated impairment of apoptotic cell recognition. FEBS Lett. 2004 ; 574 (1-3). 80-84.
41. Butler MW, Robertson I., Greene CM, ́Neill SJ, Taggart CC, McElvaney NG Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitinproteasome pathway. J Biol Chem. 2006 ; 281 (46). 34730-34735.