Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

International Journal of Pharmaceutics

Volumn 473, Issue 1-2, 2014, Pages 442-457

  Gabal, Yasmine M ^a   Kamel, Amany O ^a,c   Sammour, Omaima A ^a   Elshafeey, Ahmed H ^b,c  

^a Ain Shams University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Brain delivery; In vivo; Intranasal; Nanostructured lipid carriers; Surface charge

Indexed keywords

ANIONIC SURFACTANT; CATIONIC SURFACTANT; LIPID; NANOCARRIER; NANOSTRUCTURED LIPID CARRIER; POLOXAMER; ROPINIROLE; UNCLASSIFIED DRUG; ANTIPARKINSON AGENT; DRUG CARRIER; GEL; INDOLE DERIVATIVE; NANOMATERIAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; COMPARATIVE STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUTION; DRUG TARGETING; DRUG TOLERABILITY; DRUG UPTAKE; GEL; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY; TRANSITION TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BLOOD; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; SURFACE PROPERTY; WISTAR RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIPARKINSON AGENTS; BRAIN; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; GELS; INDOLES; LIPIDS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOSTRUCTURES; NASAL MUCOSA; PARTICLE SIZE; RATS, WISTAR; SURFACE PROPERTIES;

EID: 84905454963     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.07.025     Document Type: Article

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