Polymorphic behaviour of Compritol®888 ATO as bulk lipid and as SLN and NLC

Journal of Microencapsulation

Volumn 23, Issue 4, 2006, Pages 417-433

  Souto, E B ^a   Mehnert, W ^a   Muller R H ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

tocopherol; Compritol 888 ATO; DSC; Ketoconazole; Lipid polymorphism; NLC; SLN; X ray diffraction

Indexed keywords

ALPHA TOCOPHEROL; COSURFACTANT; DEOXYCHOLATE SODIUM; DRUG CARRIER; GLYCEROL BEHENATE; KETOCONAZOLE; NANOSTRUCTURED LIPID CARRIER; OIL; POLOXAMER; SOLID LIPID NANOPARTICLE; SURFACTANT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; EXCIPIENT; FATTY ACID; LIPID; NANOMATERIAL; NANOPARTICLE;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG IMPURITY; DRUG MIXTURE; HIGH TEMPERATURE PROCEDURES; LASER DIFFRACTION; LIPOPHILICITY; MASS RADIOGRAPHY; PHOTON CORRELATION SPECTROSCOPY; PHYSICAL CHEMISTRY; SHELF LIFE; SOLUBILITY; SYNTHESIS; X RAY DIFFRACTION; CHEMISTRY; DRUG STABILITY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; EXCIPIENTS; FATTY ACIDS; KETOCONAZOLE; LIPIDS; NANOPARTICLES; NANOSTRUCTURES; X-RAY DIFFRACTION;

EID: 33746537717     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040600612439     Document Type: Article

References (26)

1. Bunjes, H and Koch, MHJ and Westesen, K. (2000) Effect of particle size on colloidal size solid triglycerides Langmuir, 16, pp. 5234-5241.
2. Freitas, C.(1998) Feste Lipid Nanopartikel (SLN): Mechanismen der physikalischen Destabilisierung und Stabilisierung. In. Berlin: Freie Universität Berlin.
3. Freitas, C and M̈ller, RH. (1999) Correlation between log-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase European Journal of Pharmaceutics & Biopharmaceutics, 47, pp. 125-132.
4. Garti, N.(1988) Effects of surfactants on crystallization and polymorphic transformation of fats and fatty acids. In Crystallization and polymorphism of fats and fatty acids. (pp. 267-303). New York: Marcel Dekker Inc.
5. Hagemann, JW.(1988) Thermal behaviour and polymorphism of acylglycerides. In Crystallization and polymorphism of fats and fatty acids. (pp. 9-96). New York: Marcel Dekker Inc.
6. Jenning, V and Thünemann, AF and Gohla, SH. (2000) Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids International Journal of Pharmaceutics, 199, pp. 167-177.
7. Müller, RH and M̈der, K and Gohla, S. (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of art European Journal of Pharmaceutics & Biopharmaceutics, 50, pp. 161-177.
8. Müller, RH and Mäder, K and Lippacher, A and Jenning, V.(1998) Fest-flüssig (halbfeste) Lipidpartikel und Verfahren zur Herstellung hochkonzentrierter Lipidpartikeldispersionen. In. PCT application PCT/EP00/04565
9. Müller, RH and Mehnert, W and Souto, EB.(2005) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for dermal delivery. In Percutaneous absorption. (pp. 719-738). New York: Marcel Dekker, Inc.
10. Ninomiya, R and Matsuoka, K and Moroi, Y. (2003) Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: Comparison with other unconjugated bile salts Biochimica et Biophysica Acta, 1643, pp. 116-125.
11. Precht, D.(1988) Fat crystal structure in cream and butter. In Crystallization and polymorphism of fats and fatty acids. (pp. 305-355). New York: Marcel Dekker Inc.
12. Runge, S.(1998) Feste Lipidnanopartikel (SLNR®) als kolloidaler Arzneistoffträger für die orale Applikation von Ciclosporin A. In. Berlin: Freie Universität Berlin.
13. Sato, K.(1988) Crystallization of fats and fatty acids. In Crystallization and polymorphism of fats and fatty acids. Surfactant science series. (pp. 267-303). New York: Marcel Dekker Inc.
14. Sato, K and Ueno, S and Yano, J. (1999) Molecular interactions and kinetic properties of fats Proceedings of Lipid Research, 38, pp. 91-116.
15. Siekmann, B.(1995) Untersuchungen zur Herstellung und zum Rekristallisationsverhalten schmelzemulgierter intravenös applizierbarer Glyceridnanopartikel. Naturwissenschaftliche Fakultät der Technischen Universität Braunschweig. In. Braunschweig
16. Siekmann, B and Westesen, K. (1992) Submicronized parenteral carrier systems based on solid lipids Pharmaceutics & Pharmacology Letters, 1, pp. 123-126.
17. Siekmann, B and Westesen, K. (1994) Melt-homogenized solid lipid nanoparticles stabilized by the nonionic surfactant tyloxapol. I. Preparation and particle size determination Pharmaceutics & Pharmacology Letters, 3, pp. 194-197.
18. Siekmann, B and Westesen, K. (1995) Preparation and physicochemical characterization of aqueous dispersions of coenzyme Q10 nanoparticles Pharmaceutical Research, 12, pp. 201-208.
19. Souto, EB.(2005) SLN and NLC for topical delivery of antifungals. In. Berlin: Freie Universität Berlin.
20. Souto, EB and Müller, RH. (2006) Investigation of the factors influencing the incorporation of clotrimazole-loaded lipid nanoparticles prepared by hot high-pressure homogenization Journal of Microencapsulation. in press
21. Thoma, K and Serno, P and Precht, D. (1983) Röntgendiffraktometrischer Nachweis der Polymorphie Pharmaceutical Industry, 45, pp. 420-425.
22. Langevelde, A and van Malssen, K and Hollander, F and Peschar, R and Schenk, H. (1999) Structure of mono-acid even-numbered beta-triacylglycerols Acta Crytallographica, B55, pp. 114-122.
23. Westesen, K and Siekmann, B. (1994) Comparison of parenteral lipid emulsions and solid lipid nanoparticles European Journal of Pharmaceutics & Biopharmaceutics, 40(suppl.), pp. 35S.
24. Westesen, K and Siekmann, B. (1997) Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles International Journal of Pharmaceutics, 151, pp. 35-45.
25. Westesen, K and Siekmann, B and Koch, MHJ. (1993) Investigations on the physical state of lipid nanoparticles by synchroton radiation X-ray diffraction International Journal of Pharmaceutics, 93, pp. 189-199.
26. Mühlen, A.(1996) Feste Lipid - Nanopartikel mit prolongierter Wirkstoffliberation: Herstellung, Langzeitsabilität, Charakterisierung, Freisetzungsverhalten und Mechanismen. In. Berlin: Freie Universität Berlin.