The structure of a transient complex of a nonribosomal peptide synthetase and a cytochromep450 monooxygenase

Angewandte Chemie - International Edition

Volumn 53, Issue 32, 2014, Pages 8518-8522

  Haslinger, Kristina ^a   Brieke, Clara ^a   Uhlmann, Stefanie ^b   Sieverling, Lina ^a   Süssmuth, Roderich D ^b   Cryle, Max J ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

bioorganic chemistry; biosynthesis; metalloenzymes; protein protein interactions; structural biology

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; PROTEINS;

BIOORGANIC CHEMISTRY; HYDROPHOBIC INTERACTIONS; METALLOENZYMES; NONRIBOSOMAL PEPTIDE SYNTHETASES; PEPTIDYL CARRIER PROTEINS; PROTEIN-PROTEIN INTERACTIONS; SECONDARY METABOLITES; STRUCTURAL BIOLOGY;

ENZYMES;

CYTOCHROME P450; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE SYNTHASE;

CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE;

CYTOCHROME P-450 ENZYME SYSTEM; MOLECULAR STRUCTURE; PEPTIDE SYNTHASES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY;

EID: 84905443941     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201404977     Document Type: Article

References (24)

1. J. E. Baldwin, E. Abraham, Nat. Prod. Rep. 1988, 5, 129-145.
2. K. M. G. O'Connell, J. T. Hodgkinson, H. F. Sore, M. Welch, G. P. C. Salmond, D. R. Spring, Angew. Chem. 2013, 125, 10904-10932
3. Angew. Chem. Int. Ed. 2013, 52, 10706-10733.
4. M. A. Fischbach, C. T. Walsh, Chem. Rev. 2006, 106, 3468-3496.
5. G. H. Hur, C. R. Vickery, M. D. Burkart, Nat. Prod. Rep. 2012, 29, 1074-1098.
6. S. Pohle, C. Appelt, M. Roux, H.-P. Fiedler, R. D. Süssmuth, J. Am. Chem. Soc. 2011, 133, 6194-6205.
7. V. Schubert, F. DiMeo, P.-L. Saaidi, S. Bartoschek, H.-P. Fiedler, P. Trouillas, R. D. Süssmuth, Chem. Eur. J. 2014, 20, 4948-4955.
8. S. Uhlmann, R. D. Süssmuth, M. J. Cryle, ACS Chem. Biol. 2013, 8, 2586-2596.
9. M. J. Cryle, C. Brieke, K. Haslinger, Oxidative Transformations of Amino Acids and Peptides Catalysed by Cytochromes P450, Vol.39 (Eds.:, E. Farkas, M. Ryadnov,), The Royal Society of Chemistry, London, 2014, pp. 1-36.
10. T. Weber, R. Baumgartner, C. Renner, M. A. Marahiel, T. A. Holak, Structure 2000, 8, 407-418.
11. M. J. Cryle, A. Meinhart, I. Schlichting, J. Biol. Chem. 2010, 285, 24562-24574.
12. Cytochrome P450. Structure, Mechanism and Biochemistry (Ed.:, P.R. OrtizdeMontellano,), Kluwer Academics/Plenum, New York, 2005.
13. J. Crosby, M. P. Crump, Nat. Prod. Rep. 2012, 29, 1111-1137.
14. J. Bogomolovas, B. Simon, M. Sattler, G. Stier, Protein Expression Purif. 2009, 64, 16-23.
15. Y. Liu, T. Zheng, S. D. Bruner, Chem. Biol. 2011, 18, 1482-1488.
16. J. A. Sundlov, C. Shi, D. J. Wilson, C. C. Aldrich, A. M. Gulick, Chem. Biol. 2012, 19, 188-198.
17. N. Mast, W. Zheng, C. D. Stout, I. A. Pikuleva, J. Biol. Chem. 2013, 288, 4613-4624.
18. M. J. Cryle, I. Schlichting, Proc. Natl. Acad. Sci. USA 2008, 105, 15696-15701.
19. A. Tanovic, S. A. Samel, L.-O. Essen, M. A. Marahiel, Science 2008, 321, 659-663.
20. M. Mocibob, N. Ivic, M. Luic, I. Weygand-Durasevic, Structure 2013, 21, 614-626.
21. J. G. McCoy, H. D. Johnson, S. Singh, C. A. Bingman, I.-K. Lei, J. S. Thorson, G. N. Phillips, Jr., Proteins 2009, 74, 50-60.
22. L. Song, L. Laureti, C. Corre, P. Leblond, B. Aigle, G. L. Challis, J. Antibiot. 2014, 67, 71-76.
23. D. Bischoff, S. Pelzer, B. Bister, G. J. Nicholson, S. Stockert, M. Schirle, W. Wohlleben, G. Jung, R. D. Süssmuth, Angew. Chem. 2001, 113, 4824-4827
24. Angew. Chem. Int. Ed. 2001, 40, 4688-4691.