Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis

Journal of Antibiotics

Volumn 67, Issue 1, 2014, Pages 71-76

  Song, Lijiang ^a   Laureti, Luisa ^b,c,d   Corre, Christophe ^a   Leblond, Pierre ^b,c   Aigle, Bertrand ^b,c   Challis, Gregory L ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Acyl carrier protein; Cytochrome P450; Hydroxylation; Macrolactonization; Polyketide synthase; Streptomyces ambofaciens; Thioesterase

Indexed keywords

CYTOCHROME P450; MACROLIDE; POLYKETIDE; POLYKETIDE SYNTHASE; STAMBOMYCIN A; STAMBOMYCIN B; STAMBOMYCIN C; STAMBOMYCIN D; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG SYNTHESIS; GENE CLUSTER; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HOMOLOGOUS RECOMBINATION; MACROLACTONIZATION; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES AMBOFACIENS;

ANTIBIOTICS, ANTINEOPLASTIC; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; MACROLIDES; POLYKETIDES;

EID: 84893151829     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.119     Document Type: Article

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