Automated phenotyping and advanced data mining exemplified in rats transgenic for Huntington's disease

Journal of Neuroscience Methods

Volumn 234, Issue , 2014, Pages 38-53

  Urbach, Yvonne K ^a   Raber, Kerstin A ^a   Canneva, Fabio ^a   Plank, Anne C ^a   Andreasson, Theresa ^b   Ponten, Henrik ^b   Kullingsjö, Johan ^b   Nguyen, Huu Phuc ^c   Riess, Olaf ^c   von Hörsten, Stephan ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b NeuroSearch   (Sweden)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Automated phenotyping; Data mining; Huntington's disease; Transgenic rats

Indexed keywords

ACCELEROD TEST; ADULT; ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; CAGE; CALORIMETRY; COGNITION; CONTROLLED STUDY; DATA MINING; DISCRIMINANT ANALYSIS; DRINKING; EMOTIONALITY; ENERGY METABOLISM; ENVIRONMENT; EVALUATION STUDY; FEEDING; GENDER; GENOTYPE; GROUPS BY AGE; HUNTINGTON CHOREA; INTRA HOME CAGE SCREENING; JUVENILE; LEARNING; MALE; MASS SCREENING; METABOLISM; MOTOR COORDINATION; MULTIVARIATE ANALYSIS; NONHUMAN; OPERANT BEHAVIORAL TEST; PARTIAL LEAST SQUARES REGRESSION; PHENOTYPE; PHYSICAL ACTIVITY; PREPULSE INHIBITION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; RAT MODEL; REARING; SCREENING TEST; SOCIAL INTERACTION; STANDARDIZATION; STARTLE REFLEX; TASK PERFORMANCE; TRANSGENIC RAT; TWO-WAY ACTIVE AVOIDANCE TEST; WEIGHT GAIN; ANIMAL; COMPLICATION; DEVICES; DISEASE MODEL; GENETICS; HUNTINGTON DISEASE; INFORMATION PROCESSING; MUTATION; PHYSIOLOGIC MONITORING; PROCEDURES; SPRAGUE DAWLEY RAT;

HUNTINGTON PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMALS; AUTOMATIC DATA PROCESSING; DATA MINING; DISCRIMINANT ANALYSIS; DISEASE MODELS, ANIMAL; HUNTINGTON DISEASE; MONITORING, PHYSIOLOGIC; MULTIVARIATE ANALYSIS; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC;

EID: 84905405065     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2014.06.017     Document Type: Article

References (38)

1. Balci F., Oakeshott S., Shamy J.L., El-Khodor B.F., Filippov I., Mushlin R., et al. High-throughput automated phenotyping of two genetic mouse models of Huntington's disease. PLoS Curr 2013, 5.
2. Bode F.J., Stephan M., Suhling H., Pabst R., Straub R.H., Raber K.A., et al. Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Hum Mol Genet 2008, 17:2595-2609.
3. Bode F.J., Stephan M., Wiehager S., Nguyen H.P., Bjorkqvist M., von Horsten S., et al. Increased numbers of motor activity peaks during light cycle are associated with reductions in adrenergic alpha(2)-receptor levels in a transgenic Huntington's disease rat model. Behav Brain Res 2009, 205:175-182.
4. Bogo V., Hill T.A., Young R.W. Comparison of accelerod and rotarod sensitivity in detecting ethanol- and acrylamide-induced performance decrement in rats: review of experimental considerations of rotating rod systems. Neurotoxicology 1981, 2:765-787.
5. Brooks S., Fielding S., Dobrossy M., von Horsten S., Dunnett S. Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Res Bull 2009, 79:310-315.
6. Casaca Carreira J.J.A, Zeef D., Kocabicak E., Vlamings R., von Hörsten S., Temel Y. Transgenic rat models of Huntington's disease. Curr Topics Behav Neurosci 2013, (epub ahead of print).
7. Crabbe J.C., Wahlsten D., Dudek B.C. Genetics of mouse behavior: interactions with laboratory environment. Science 1999, 284:1670-1672.
8. Crawley J.N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 1999, 835:18-26.
9. Crawley J.N., Belknap J.K., Collins A., Crabbe J.C., Frankel W., Henderson N., et al. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) 1997, 132:107-124.
10. Crawley J.N., Paylor R. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm Behav 1997, 31:197-211.
11. de Visser L., van den Bos R., Kuurman W.W., Kas M.J., Spruijt B.M. Novel approach to the behavioural characterization of inbred mice: automated home cage observations. Genes Brain Behav 2006, 5:458-466.
12. Eagle D.M., Humby T., Dunnett S.B., Robbins T.W. Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behav Neurosci 1999, 113:718-731.
13. File S.E., Hyde J.R. Can social interaction be used to measure anxiety?. Br J Pharmacol 1978, 62:19-24.
14. File S.E., Mahal A., Mangiarini L., Bates G.P. Striking changes in anxiety in Huntington's disease transgenic mice. Brain Res 1998, 805:234-240.
15. Frerker N., Raber K., Bode F., Skripuletz T., Nave H., Klemann C., et al. Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions. Clin Chem Lab Med 2009, 47:275-287.
16. 2+ in transgenic Huntington disease rats. J Biol Chem 2008, 283:30715-30724.
17. Gerlai R. Phenomics: fiction or the future?. Trends Neurosci 2002, 25:506-509.
18. Jackson J.E. A User's Guide To Principle Component 1991, John Wiley and Sons, New York.
19. Jhuang H., Garrote E., Mutch J., Yu X., Khilnani V., Poggio T., et al. Automated home-cage behavioural phenotyping of mice. Nat Commun 2010, 1:68.
20. Jones B.J., Roberts D.J. The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J Pharm Pharmacol 1968, 20:302-304.
21. Karl T., Hoffmann T., Pabst R., von Horsten S. Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity. Pharmacol Biochem Behav 2003, 75:869-879.
22. Karl T., Hoffmann T., Pabst R., von Horsten S. Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences. Physiol Behav 2003, 80:123-134.
23. Karl T., Pabst R., von Horsten S. Behavioral phenotyping of mice in pharmacological and toxicological research. Exp Toxicol Pathol 2003, 55:69-83.
24. Kas M.J., Van Ree J.M. Dissecting complex behaviours in the post-genomic era. Trends Neurosci 2004, 27:366-369.
25. Koch M., Fendt M., Kretschmer B.D. Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats. Behav Brain Res 2000, 117:153-162.
26. Krackow S., Vannoni E., Codita A., Mohammed A.H., Cirulli F., Branchi I., et al. Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage. Genes Brain Behav 2010, 9:722-731.
27. McIlwain K.L., Merriweather M.Y., Yuva-Paylor L.A., Paylor R. The use of behavioral test batteries: effects of training history. Physiol Behav 2001, 73:705-717.
28. Nguyen H.P., Kobbe P., Rahne H., Worpel T., Jager B., Stephan M., et al. Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease. Hum Mol Genet 2006, 15:3177-3194.
29. Rehbinder C., Baneux P., Forbes D., van Herck H., Nicklas W., Rugaya Z., et al. FELASA recommendations for the health monitoring of mouse, rat, hamster, gerbil, guinea pig and rabbit experimental units. Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Animal Health accepted by the FELASA Board of Management, November 1995. Lab Anim 1996, 30:193-208.
30. Stiedl O., Jansen R.F., Pieneman A.W., Ogren S.O., Meyer M. Assessing aversive emotional states through the heart in mice: implications for cardiovascular dysregulation in affective disorders. Neurosci Biobehav Rev 2009, 33:181-190.
31. Swerdlow N.R., Geyer M.A., Braff D.L. Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) 2001, 156:194-215.
32. Tecott L.H., Nestler E.J. Neurobehavioral assessment in the information age. Nat Neurosci 2004, 7:462-466.
33. Urbach Y.K., Bode F.J., Nguyen H.P., Riess O., von Horsten S. Neurobehavioral tests in rat models of degenerative brain diseases. Methods Mol Biol 2010, 597:333-356.
34. van der Staay F.J., Steckler T. Behavioural phenotyping of mouse mutants. Behav Brain Res 2001, 125:3-12.
35. von Horsten S., Schmitt I., Nguyen H.P., Holzmann C., Schmidt T., Walther T., et al. Transgenic rat model of Huntington's disease. Hum Mol Genet 2003, 12:617-624.
36. Wahlsten D., Rustay N.R., Metten P., Crabbe J.C. In search of a better mouse test. Trends Neurosci 2003, 26:132-136.
37. Wallace D.L., Han M.H., Graham D.L., Green T.A., Vialou V., Iniguez S.D., et al. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci 2009, 12:200-209.
38. Wold S. Crossvalidatory estimation of the number of components in factor and principal components models. Technometrics 1978, 20:397-405.