메뉴 건너뛰기




Volumn 47, Issue 3, 2009, Pages 275-287

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions

Author keywords

Comprehensive phenotyping; Dipeptidyl peptidase 4; Inhibitors; Neuropeptide Y

Indexed keywords

AMINOTRANSFERASE; CORTICOTROPIN; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; GLUCAGON LIKE PEPTIDE 1; INTERLEUKIN 10; INTERLEUKIN 6; LEPTIN; TRIACYLGLYCEROL;

EID: 63849165577     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.064     Document Type: Article
Times cited : (32)

References (51)
  • 1
    • 3843072211 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitors for the treatment of diabetes
    • Weber AE. Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. J Med Chem 2004;47:4135-41.
    • (2004) J Med Chem , vol.47 , pp. 4135-4141
    • Weber, A.E.1
  • 2
    • 0141956543 scopus 로고    scopus 로고
    • Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences
    • Karl T, Hoffmann T, Pabst R, von Horsten S. Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences. Physiol Behav 2003;80:123-34.
    • (2003) Physiol Behav , vol.80 , pp. 123-134
    • Karl, T.1    Hoffmann, T.2    Pabst, R.3    von Horsten, S.4
  • 3
    • 0043027007 scopus 로고    scopus 로고
    • Behavioral phenotyping of mice in pharmacological and toxicological research
    • Karl T, Pabst R, von Horsten S. Behavioral phenotyping of mice in pharmacological and toxicological research. Exp Toxicol Pathol 2003;55:69-83.
    • (2003) Exp Toxicol Pathol , vol.55 , pp. 69-83
    • Karl, T.1    Pabst, R.2    von Horsten, S.3
  • 4
    • 0141938104 scopus 로고    scopus 로고
    • Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (Dipeptidyl-peptidase IV; CD26) gene in rats
    • Karl T, Chwalisz WT, Wedekind D, Hedrich HJ, Hoffmann T, Jacobs R, et al. Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (Dipeptidyl-peptidase IV; CD26) gene in rats. Regul Pept 2003;115:81-90.
    • (2003) Regul Pept , vol.115 , pp. 81-90
    • Karl, T.1    Chwalisz, W.T.2    Wedekind, D.3    Hedrich, H.J.4    Hoffmann, T.5    Jacobs, R.6
  • 5
    • 0142106481 scopus 로고    scopus 로고
    • Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity
    • Karl T, Hoffmann T, Pabst R, von Horsten S. Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity. Pharmacol Biochem Behav 2003;75:869-79.
    • (2003) Pharmacol Biochem Behav , vol.75 , pp. 869-879
    • Karl, T.1    Hoffmann, T.2    Pabst, R.3    von Horsten, S.4
  • 8
    • 0026439102 scopus 로고
    • An active-site mutation (Gly633→Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum
    • Tsuji E, Misumi Y, Fujiwara T, Takami N, Ogata S, Ikehara Y. An active-site mutation (Gly633→Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum. Biochemistry 1992;31:11921-7.
    • (1992) Biochemistry , vol.31 , pp. 11921-11927
    • Tsuji, E.1    Misumi, Y.2    Fujiwara, T.3    Takami, N.4    Ogata, S.5    Ikehara, Y.6
  • 10
    • 1842484788 scopus 로고    scopus 로고
    • Laboratory animals: The Renaissance rat
    • Abbott A. Laboratory animals: the Renaissance rat. Nature 2004;428:464-6.
    • (2004) Nature , vol.428 , pp. 464-466
    • Abbott, A.1
  • 11
    • 0036250938 scopus 로고    scopus 로고
    • Rat genetics: Attaching physiology and pharmacology to the genome
    • Jacob HJ, Kwitek AE. Rat genetics: attaching physiology and pharmacology to the genome. Nat Rev Genet 2002; 3:33-42.
    • (2002) Nat Rev Genet , vol.3 , pp. 33-42
    • Jacob, H.J.1    Kwitek, A.E.2
  • 12
    • 33750210519 scopus 로고    scopus 로고
    • Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease
    • Nguyen HP, Kobbe P, Rahne H, Worpel T, Jager B, Stephan M, et al. Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease. Hum Mol Genet 2006;15:3177-94.
    • (2006) Hum Mol Genet , vol.15 , pp. 3177-3194
    • Nguyen, H.P.1    Kobbe, P.2    Rahne, H.3    Worpel, T.4    Jager, B.5    Stephan, M.6
  • 14
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept 1999;85: 9-24.
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 16
    • 0842324615 scopus 로고    scopus 로고
    • Chemokines: Multiple levels of leukocyte migration control
    • Moser B, Wolf M, Walz A, Loetscher P. Chemokines: multiple levels of leukocyte migration control. Trends Immunol 2004;25:75-84.
    • (2004) Trends Immunol , vol.25 , pp. 75-84
    • Moser, B.1    Wolf, M.2    Walz, A.3    Loetscher, P.4
  • 17
    • 33846670732 scopus 로고    scopus 로고
    • Finding new treatments for diabetes - how many, how fast how good?
    • Nathan DM. Finding new treatments for diabetes - how many, how fast how good? N Engl J Med 2007;356: 437-40.
    • (2007) N Engl J Med , vol.356 , pp. 437-440
    • Nathan, D.M.1
  • 18
    • 0027176647 scopus 로고
    • Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides
    • Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach FH. Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides. Am J Physiol 1993;265:G81-9.
    • (1993) Am J Physiol , vol.265
    • Tiruppathi, C.1    Miyamoto, Y.2    Ganapathy, V.3    Leibach, F.H.4
  • 19
    • 33846691234 scopus 로고    scopus 로고
    • Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4
    • Frerker N, Wagner L, Wolf R, Heiser U, Hoffmann T, Rahfeld JU, et al. Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4. Peptides 2007;28:257-68.
    • (2007) Peptides , vol.28 , pp. 257-268
    • Frerker, N.1    Wagner, L.2    Wolf, R.3    Heiser, U.4    Hoffmann, T.5    Rahfeld, J.U.6
  • 22
    • 10644246130 scopus 로고    scopus 로고
    • In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats
    • Brabant G, Nave H, Horn R, Anderwald C, Muller G, Roden M. In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats. Eur J Clin Invest 2004;34:831-7.
    • (2004) Eur J Clin Invest , vol.34 , pp. 831-837
    • Brabant, G.1    Nave, H.2    Horn, R.3    Anderwald, C.4    Muller, G.5    Roden, M.6
  • 24
    • 0035181853 scopus 로고    scopus 로고
    • Factors influencing behavior of group-housed male rats in the social interaction test: Focus on cohort removal
    • Kask A, Nguyen HP, Pabst R, von Horsten S. Factors influencing behavior of group-housed male rats in the social interaction test: focus on cohort removal. Physiol Behav 2001;74:277-82.
    • (2001) Physiol Behav , vol.74 , pp. 277-282
    • Kask, A.1    Nguyen, H.P.2    Pabst, R.3    von Horsten, S.4
  • 25
    • 0033777937 scopus 로고    scopus 로고
    • Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay
    • Straub RH, Schaller T, Miller LE, von Horsten S, Jessop DS, Falk W, et al. Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay. J Neurochem 2000;75:2464-71.
    • (2000) J Neurochem , vol.75 , pp. 2464-2471
    • Straub, R.H.1    Schaller, T.2    Miller, L.E.3    von Horsten, S.4    Jessop, D.S.5    Falk, W.6
  • 26
    • 0036568525 scopus 로고    scopus 로고
    • Kinetics of the early recruitment of leukocyte subsets at the sites of tumor cells in the lungs: Natural killer (NK) cells rapidly attract monocytes but not lymphocytes in the surveillance of micrometastasis
    • Shingu K, Helfritz A, Kuhlmann S, Zielinska-Skowronek M, Jacobs R, Schmidt RE, et al. Kinetics of the early recruitment of leukocyte subsets at the sites of tumor cells in the lungs: natural killer (NK) cells rapidly attract monocytes but not lymphocytes in the surveillance of micrometastasis. Int J Cancer 2002;99:74-81.
    • (2002) Int J Cancer , vol.99 , pp. 74-81
    • Shingu, K.1    Helfritz, A.2    Kuhlmann, S.3    Zielinska-Skowronek, M.4    Jacobs, R.5    Schmidt, R.E.6
  • 27
    • 0032493673 scopus 로고    scopus 로고
    • Modulation of innate immune functions by intracerebroventricularly applied neuropeptide Y: Dose and time dependent effects
    • von Horsten S, Ballof J, Helfritz F, Nave H, Meyer D, Schmidt RE, et al. Modulation of innate immune functions by intracerebroventricularly applied neuropeptide Y: dose and time dependent effects. Life Sci 1998;63: 909-22.
    • (1998) Life Sci , vol.63 , pp. 909-922
    • von Horsten, S.1    Ballof, J.2    Helfritz, F.3    Nave, H.4    Meyer, D.5    Schmidt, R.E.6
  • 28
    • 0026518369 scopus 로고
    • Calculation of lytic units for the expression of cell-mediated cytotoxicity
    • Bryant J, Day R, Whiteside TL, Herberman RB. Calculation of lytic units for the expression of cell-mediated cytotoxicity. J Immunol Methods 1992;146:91-103.
    • (1992) J Immunol Methods , vol.146 , pp. 91-103
    • Bryant, J.1    Day, R.2    Whiteside, T.L.3    Herberman, R.B.4
  • 29
    • 25844459084 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: Potential importance of selectivity over dipeptidyl peptidases 8 and 9
    • Lankas GR, Leiting B, Roy RS, Eiermann GJ, Beconi MG, Biftu T, et al. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 2005;54:2988-94.
    • (2005) Diabetes , vol.54 , pp. 2988-2994
    • Lankas, G.R.1    Leiting, B.2    Roy, R.S.3    Eiermann, G.J.4    Beconi, M.G.5    Biftu, T.6
  • 30
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 2003;52: 741-50.
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3    Ehses, J.A.4    Pamir, N.5    Lynn, F.C.6
  • 31
    • 0034666562 scopus 로고    scopus 로고
    • Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice
    • Ahren B, Holst JJ, Martensson H, Balkan B. Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. Eur J Pharmacol 2000; 404:239-45.
    • (2000) Eur J Pharmacol , vol.404 , pp. 239-245
    • Ahren, B.1    Holst, J.J.2    Martensson, H.3    Balkan, B.4
  • 32
    • 0037974604 scopus 로고    scopus 로고
    • Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
    • Conarello SL, Li Z, Ronan J, Roy RS, Zhu L, Jiang G, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci USA 2003;100:6825-30.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6825-6830
    • Conarello, S.L.1    Li, Z.2    Ronan, J.3    Roy, R.S.4    Zhu, L.5    Jiang, G.6
  • 34
    • 3242779514 scopus 로고    scopus 로고
    • Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice
    • Ruter J, Hoffmann T, Demuth HU, Moschansky P, Klapp BF, Hildebrandt M. Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice. Biol Chem 2004;385:537-41.
    • (2004) Biol Chem , vol.385 , pp. 537-541
    • Ruter, J.1    Hoffmann, T.2    Demuth, H.U.3    Moschansky, P.4    Klapp, B.F.5    Hildebrandt, M.6
  • 35
    • 6044261454 scopus 로고    scopus 로고
    • Role of dipeptidyl peptidase IV in regulating activity of Naq/Hq exchanger isoform NHE3 in proximal tubule cells
    • Girardi AC, Knauf F, Demuth HU, Aronson PS. Role of dipeptidyl peptidase IV in regulating activity of Naq/Hq exchanger isoform NHE3 in proximal tubule cells. Am J Physiol Cell Physiol 2004;287:C1238-45.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Girardi, A.C.1    Knauf, F.2    Demuth, H.U.3    Aronson, P.S.4
  • 36
    • 0025137029 scopus 로고
    • Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains
    • Tiruppathi C, Miyamoto Y, Ganapathy V, Roesel RA, Whitford GM, Leibach FH. Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains. J Biol Chem 1990;265:1476-83.
    • (1990) J Biol Chem , vol.265 , pp. 1476-1483
    • Tiruppathi, C.1    Miyamoto, Y.2    Ganapathy, V.3    Roesel, R.A.4    Whitford, G.M.5    Leibach, F.H.6
  • 37
    • 0026794360 scopus 로고
    • Biosynthesis and degradation of altered immature forms of intestinal dipeptidyl peptidase IV in a rat strain lacking the enzyme
    • Erickson RH, Suzuki Y, Sedlmayer A, Kim YS. Biosynthesis and degradation of altered immature forms of intestinal dipeptidyl peptidase IV in a rat strain lacking the enzyme. J Biol Chem 1992;267:21623-9.
    • (1992) J Biol Chem , vol.267 , pp. 21623-21629
    • Erickson, R.H.1    Suzuki, Y.2    Sedlmayer, A.3    Kim, Y.S.4
  • 38
    • 34548437672 scopus 로고    scopus 로고
    • AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis
    • Broxmeyer HE, Hangoc G, Cooper S, Campbell T, Ito S, Mantel C. AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis. Ann NY Acad Sci 2007;1006:1-19.
    • (2007) Ann NY Acad Sci , vol.1006 , pp. 1-19
    • Broxmeyer, H.E.1    Hangoc, G.2    Cooper, S.3    Campbell, T.4    Ito, S.5    Mantel, C.6
  • 39
    • 0035796779 scopus 로고    scopus 로고
    • Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: Mobilization of B-1-like B-lymphocytes and activated monocytes
    • Bedoui S, Kuhlmann S, Nave H, Drube J, Pabst R, von Horsten S. Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: mobilization of B-1-like B-lymphocytes and activated monocytes. J Neuroimmunol 2001;117:125-32.
    • (2001) J Neuroimmunol , vol.117 , pp. 125-132
    • Bedoui, S.1    Kuhlmann, S.2    Nave, H.3    Drube, J.4    Pabst, R.5    von Horsten, S.6
  • 40
    • 0038759066 scopus 로고    scopus 로고
    • Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen
    • Yan S, Marguet D, Dobers J, Reutter W, Fan H. Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen. Eur J Immunol 2003;33:1519-27.
    • (2003) Eur J Immunol , vol.33 , pp. 1519-1527
    • Yan, S.1    Marguet, D.2    Dobers, J.3    Reutter, W.4    Fan, H.5
  • 42
    • 33947686803 scopus 로고    scopus 로고
    • TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
    • Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, et al. TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J Immunol 2007; 178:4632-40.
    • (2007) J Immunol , vol.178 , pp. 4632-4640
    • Preller, V.1    Gerber, A.2    Wrenger, S.3    Togni, M.4    Marguet, D.5    Tadje, J.6
  • 43
    • 0030744259 scopus 로고    scopus 로고
    • Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells
    • Reinhold D, Bank U, Buhling F, Lendeckel U, Faust J, Neubert K, et al. Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells. Immunology 1997; 91:354-60.
    • (1997) Immunology , vol.91 , pp. 354-360
    • Reinhold, D.1    Bank, U.2    Buhling, F.3    Lendeckel, U.4    Faust, J.5    Neubert, K.6
  • 44
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic {beta}-cell mass and function in a rodent model of type 2 diabetes
    • Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic {beta}-cell mass and function in a rodent model of type 2 diabetes. Diabetes 2006;55:1695-704.
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3    Roy, R.S.4    Li, Z.5    Zycband, E.6
  • 46
    • 31044444463 scopus 로고    scopus 로고
    • Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
    • Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005;115:3579-86.
    • (2005) J Clin Invest , vol.115 , pp. 3579-3586
    • Rosenbaum, M.1    Goldsmith, R.2    Bloomfield, D.3    Magnano, A.4    Weimer, L.5    Heymsfield, S.6
  • 47
    • 33846817119 scopus 로고    scopus 로고
    • Jarmolowska B, Bielikowicz K, Iwan M, Sidor K, Kostyra E, Kaczmarski M. Serum activity of dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) in breast-fed infants with symptoms of allergy. Peptides 2007;28:678-82.
    • Jarmolowska B, Bielikowicz K, Iwan M, Sidor K, Kostyra E, Kaczmarski M. Serum activity of dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) in breast-fed infants with symptoms of allergy. Peptides 2007;28:678-82.
  • 49
    • 0033732324 scopus 로고    scopus 로고
    • Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
    • horsell A, Michalkiewicz M, Dumont Y, Quirion R, Caberlotto L, Rimondini R, et al. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc Natl Acad Sci USA 2000;97:12852-7.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12852-12857
    • horsell, A.1    Michalkiewicz, M.2    Dumont, Y.3    Quirion, R.4    Caberlotto, L.5    Rimondini, R.6
  • 50
  • 51
    • 0036341096 scopus 로고    scopus 로고
    • Effect of neuropeptide Y on inflammatory paw edema in the rat: Involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)
    • Dimitrijevic M, Stanojevic S, Vujic V, Kovacevic-Jovanovic V, Beck-Sickinger A, Demuth H, et al. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). J Neuroimmunol 2002;129:35-42.
    • (2002) J Neuroimmunol , vol.129 , pp. 35-42
    • Dimitrijevic, M.1    Stanojevic, S.2    Vujic, V.3    Kovacevic-Jovanovic, V.4    Beck-Sickinger, A.5    Demuth, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.