메뉴 건너뛰기




Volumn 35, Issue 6, 2014, Pages 1379-1388

Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD PROTEIN; TRANSCRIPTION FACTOR SIX1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; HOMEODOMAIN PROTEIN; SIX1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 84905373495     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu050     Document Type: Article
Times cited : (31)

References (49)
  • 1
    • 84873931378 scopus 로고    scopus 로고
    • Targeted treatments for cervical cancer: a review
    • Peralta-Zaragoza, O. et al. (2012) Targeted treatments for cervical cancer: a review. Onco. Targets. Ther., 5, 315-328.
    • (2012) Onco. Targets. Ther , vol.5 , pp. 315-328
    • Peralta-Zaragoza, O.1
  • 2
    • 84860818533 scopus 로고    scopus 로고
    • American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    • Saslow, D. et al.; ACS-ASCCP-ASCP Cervical Cancer Guideline Committee. (2012) American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Cancer J. Clin., 62, 147-172.
    • (2012) Cancer J. Clin , vol.62 , pp. 147-172
    • Saslow, D.1
  • 3
    • 0023683216 scopus 로고
    • Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA
    • Pirisi, L. et al. (1988) Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis, 9, 1573-1579.
    • (1988) Carcinogenesis , vol.9 , pp. 1573-1579
    • Pirisi, L.1
  • 4
    • 0023152810 scopus 로고
    • Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA
    • Pirisi, L. et al. (1987) Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol., 61, 1061-1066.
    • (1987) J. Virol , vol.61 , pp. 1061-1066
    • Pirisi, L.1
  • 5
    • 43949111007 scopus 로고    scopus 로고
    • Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer
    • Wan, F. et al. (2008) Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer. Int. J. Cancer, 123, 32-40.
    • (2008) Int. J. Cancer , vol.123 , pp. 32-40
    • Wan, F.1
  • 6
    • 0041326752 scopus 로고    scopus 로고
    • The role of Six1 in mammalian auditory system development
    • Zheng, W. et al. (2003) The role of Six1 in mammalian auditory system development. Development, 130, 3989-4000.
    • (2003) Development , vol.130 , pp. 3989-4000
    • Zheng, W.1
  • 7
    • 77958481255 scopus 로고    scopus 로고
    • Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development
    • Ikeda, K. et al. (2010) Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int. J. Dev. Biol., 54, 1453-1464.
    • (2010) Int. J. Dev. Biol , vol.54 , pp. 1453-1464
    • Ikeda, K.1
  • 8
    • 0041853845 scopus 로고    scopus 로고
    • Six1 is required for the early organogenesis of mammalian kidney
    • Xu, P.X. et al. (2003) Six1 is required for the early organogenesis of mammalian kidney. Development, 130, 3085-3094.
    • (2003) Development , vol.130 , pp. 3085-3094
    • Xu, P.X.1
  • 9
    • 42049120053 scopus 로고    scopus 로고
    • Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation
    • Coletta, R.D. et al. (2008) Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation. Cancer Res., 68, 2204-2213.
    • (2008) Cancer Res , vol.68 , pp. 2204-2213
    • Coletta, R.D.1
  • 10
    • 34248162523 scopus 로고    scopus 로고
    • Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival
    • Behbakht, K. et al. (2007) Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Res., 67, 3036-3042.
    • (2007) Cancer Res , vol.67 , pp. 3036-3042
    • Behbakht, K.1
  • 11
    • 85026153280 scopus 로고    scopus 로고
    • Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues
    • Zheng, X.H. et al. (2010) Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues. Int. J. Gynecol. Cancer, 20, 1587-1592.
    • (2010) Int. J. Gynecol. Cancer , vol.20 , pp. 1587-1592
    • Zheng, X.H.1
  • 12
    • 77954709872 scopus 로고    scopus 로고
    • Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1
    • Ng, K.T. et al. (2010) Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1. Int. J. Cancer, 127, 859-872.
    • (2010) Int. J. Cancer , vol.127 , pp. 859-872
    • Ng, K.T.1
  • 13
    • 56849100883 scopus 로고    scopus 로고
    • The six family of homeobox genes in development and cancer
    • Christensen, K.L. et al. (2008) The six family of homeobox genes in development and cancer. Adv. Cancer Res., 101, 93-126.
    • (2008) Adv. Cancer Res , vol.101 , pp. 93-126
    • Christensen, K.L.1
  • 14
    • 78650359160 scopus 로고    scopus 로고
    • Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth
    • Micalizzi, D.S. et al. (2010) Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res., 70, 10371-10380.
    • (2010) Cancer Res , vol.70 , pp. 10371-10380
    • Micalizzi, D.S.1
  • 15
    • 70349213381 scopus 로고    scopus 로고
    • The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
    • Micalizzi, D.S. et al. (2009) The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J. Clin. Invest., 119, 2678-2690.
    • (2009) J. Clin. Invest , vol.119 , pp. 2678-2690
    • Micalizzi, D.S.1
  • 16
    • 85027953636 scopus 로고    scopus 로고
    • Expression and significance of Six1 and Ezrin in cervical cancer tissue
    • Tan, J. et al. (2011) Expression and significance of Six1 and Ezrin in cervical cancer tissue. Tumour Biol., 32, 1241-1247.
    • (2011) Tumour Biol , vol.32 , pp. 1241-1247
    • Tan, J.1
  • 17
    • 12344330424 scopus 로고    scopus 로고
    • limmaGUI: a graphical user interface for linear modeling of microarray data
    • Wettenhall, J.M. et al. (2004) limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics, 20, 3705-3706.
    • (2004) Bioinformatics , vol.20 , pp. 3705-3706
    • Wettenhall, J.M.1
  • 18
    • 35748949257 scopus 로고    scopus 로고
    • A comparison of background correction methods for two-colour microarrays
    • Ritchie, M.E. et al. (2007) A comparison of background correction methods for two-colour microarrays. Bioinformatics, 23, 2700-2707.
    • (2007) Bioinformatics , vol.23 , pp. 2700-2707
    • Ritchie, M.E.1
  • 19
    • 0000128027 scopus 로고    scopus 로고
    • Dpc4 transcriptional activation and dysfunction in cancer cells
    • Dai, J.L. et al. (1998) Dpc4 transcriptional activation and dysfunction in cancer cells. Cancer Res., 58, 4592-4597.
    • (1998) Cancer Res , vol.58 , pp. 4592-4597
    • Dai, J.L.1
  • 20
    • 0036439238 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial morphogenesis
    • Schock, F. et al. (2002) Molecular mechanisms of epithelial morphogenesis. Annu. Rev. Cell Dev. Biol., 18, 463-493.
    • (2002) Annu. Rev. Cell Dev. Biol , vol.18 , pp. 463-493
    • Schock, F.1
  • 21
    • 79952725039 scopus 로고    scopus 로고
    • Involvement of the TGF-beta and betacatenin pathways in pelvic lymph node metastasis in early-stage cervical cancer
    • Noordhuis, M.G. et al. (2011) Involvement of the TGF-beta and betacatenin pathways in pelvic lymph node metastasis in early-stage cervical cancer. Clin. Cancer Res., 17, 1317-1330.
    • (2011) Clin. Cancer Res , vol.17 , pp. 1317-1330
    • Noordhuis, M.G.1
  • 22
    • 84884326165 scopus 로고    scopus 로고
    • TGF-β regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes
    • Kowli, S. et al. (2013) TGF-β regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes. Virology, 447, 63-73.
    • (2013) Virology , vol.447 , pp. 63-73
    • Kowli, S.1
  • 23
    • 75649088874 scopus 로고    scopus 로고
    • Mechanisms of the epithelial-mesenchymal transition by TGF-beta
    • Wendt, M.K. et al. (2009) Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncol., 5, 1145-1168.
    • (2009) Future Oncol , vol.5 , pp. 1145-1168
    • Wendt, M.K.1
  • 24
    • 78649982907 scopus 로고    scopus 로고
    • The dynamic roles of TGF-β in cancer
    • Meulmeester, E. et al. (2011) The dynamic roles of TGF-β in cancer. J. Pathol., 223, 205-218.
    • (2011) J. Pathol , vol.223 , pp. 205-218
    • Meulmeester, E.1
  • 25
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-beta signaling
    • Zhang, Y.E. (2009) Non-Smad pathways in TGF-beta signaling. Cell Res., 19, 128-139.
    • (2009) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 26
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani, S.A. et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 27
    • 84872877297 scopus 로고    scopus 로고
    • CD44+/CD24-ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival
    • Meng, E. et al. (2012) CD44+/CD24-ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival. Clin. Exp. Metastasis, 29, 939-948.
    • (2012) Clin. Exp. Metastasis , vol.29 , pp. 939-948
    • Meng, E.1
  • 28
    • 33751346643 scopus 로고    scopus 로고
    • CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    • Sheridan, C. et al. (2006) CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res., 8, R59.
    • (2006) Breast Cancer Res , vol.8 , pp. R59
    • Sheridan, C.1
  • 29
    • 81155130805 scopus 로고    scopus 로고
    • Silencing oncogene expression in cervical cancer stemlike cells inhibits their cell growth and self-renewal ability
    • Gu, W. et al. (2011) Silencing oncogene expression in cervical cancer stemlike cells inhibits their cell growth and self-renewal ability. Cancer Gene Ther., 18, 897-905.
    • (2011) Cancer Gene Ther , vol.18 , pp. 897-905
    • Gu, W.1
  • 30
    • 84873034242 scopus 로고    scopus 로고
    • Expression and functional role of ALDH1 in cervical carcinoma cells
    • Rao, Q.X. et al. (2012) Expression and functional role of ALDH1 in cervical carcinoma cells. Asian Pac. J. Cancer Prev., 13, 1325-1331.
    • (2012) Asian Pac. J. Cancer Prev , vol.13 , pp. 1325-1331
    • Rao, Q.X.1
  • 31
    • 80051565199 scopus 로고    scopus 로고
    • The expression of ALDH1 in cervical carcinoma
    • Yao, T. et al. (2011) The expression of ALDH1 in cervical carcinoma. Med. Sci. Monit., 17, HY21-HY26.
    • (2011) Med. Sci. Monit , vol.17 , pp. HY21-HY26
    • Yao, T.1
  • 32
    • 2342590630 scopus 로고    scopus 로고
    • The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1
    • Coletta, R.D. et al. (2004) The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. Proc. Natl Acad. Sci. USA, 101, 6478-6483.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6478-6483
    • Coletta, R.D.1
  • 33
    • 84875205667 scopus 로고    scopus 로고
    • Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression
    • Li, Z. et al. (2013) Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression. PLoS One, 8, e59203.
    • (2013) PLoS One , vol.8
    • Li, Z.1
  • 34
    • 34548555679 scopus 로고    scopus 로고
    • Overexpression of VEGF and TGF-beta1 mRNA in Pap smears correlates with progression of cervical intraepithelial neoplasia to cancer: implication of YY1 in cervical tumorigenesis and HPV infection
    • Baritaki, S. et al. (2007) Overexpression of VEGF and TGF-beta1 mRNA in Pap smears correlates with progression of cervical intraepithelial neoplasia to cancer: implication of YY1 in cervical tumorigenesis and HPV infection. Int. J. Oncol., 31, 69-79.
    • (2007) Int. J. Oncol , vol.31 , pp. 69-79
    • Baritaki, S.1
  • 35
    • 0035861541 scopus 로고    scopus 로고
    • Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
    • Bhowmick, N.A. et al. (2001) Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J. Biol. Chem., 276, 46707-46713.
    • (2001) J. Biol. Chem , vol.276 , pp. 46707-46713
    • Bhowmick, N.A.1
  • 36
    • 34248584887 scopus 로고    scopus 로고
    • Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    • Galliher, A.J. et al. (2007) Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer Res., 67, 3752-3758.
    • (2007) Cancer Res , vol.67 , pp. 3752-3758
    • Galliher, A.J.1
  • 37
    • 33847770211 scopus 로고    scopus 로고
    • TGF-beta signaling in breast cancer
    • Buck, M.B. et al. (2006) TGF-beta signaling in breast cancer. Ann. N. Y. Acad. Sci., 1089, 119-126.
    • (2006) Ann. N. Y. Acad. Sci , vol.1089 , pp. 119-126
    • Buck, M.B.1
  • 38
    • 0037093203 scopus 로고    scopus 로고
    • Fibronectin-and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation
    • Jiang, F. et al. (2002) Fibronectin-and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation. Blood, 99, 3579-3584.
    • (2002) Blood , vol.99 , pp. 3579-3584
    • Jiang, F.1
  • 39
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin, M. et al. (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell, 11, 259-273.
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1
  • 40
    • 33747086130 scopus 로고    scopus 로고
    • Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells
    • Galliher, A.J. et al. (2006) Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Breast Cancer Res., 8, R42.
    • (2006) Breast Cancer Res , vol.8 , pp. R42
    • Galliher, A.J.1
  • 41
    • 0029786329 scopus 로고    scopus 로고
    • Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
    • Lavoie, J.N. et al. (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem., 271, 20608-20616.
    • (1996) J. Biol. Chem , vol.271 , pp. 20608-20616
    • Lavoie, J.N.1
  • 42
    • 34547673869 scopus 로고    scopus 로고
    • Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
    • Yoshino, Y. et al. (2006) Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. Int. J. Oncol., 29, 981-987.
    • (2006) Int. J. Oncol , vol.29 , pp. 981-987
    • Yoshino, Y.1
  • 43
    • 0141482096 scopus 로고    scopus 로고
    • p38 kinase is a key signaling molecule for H-Rasinduced cell motility and invasive phenotype in human breast epithelial cells
    • Kim, M.S. et al. (2003) p38 kinase is a key signaling molecule for H-Rasinduced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res., 63, 5454-5461.
    • (2003) Cancer Res , vol.63 , pp. 5454-5461
    • Kim, M.S.1
  • 44
    • 71549116718 scopus 로고    scopus 로고
    • Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells
    • Chen, L. et al. (2009) Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells. Cancer Res., 69, 8853-8861.
    • (2009) Cancer Res , vol.69 , pp. 8853-8861
    • Chen, L.1
  • 45
    • 84869778648 scopus 로고    scopus 로고
    • Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27
    • Lin, S.P. et al. (2012) Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS One, 7, e49605.
    • (2012) PLoS One , vol.7
    • Lin, S.P.1
  • 46
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • Wagner, E.F. et al. (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer, 9, 537-549.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1
  • 47
    • 13444268127 scopus 로고    scopus 로고
    • Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
    • Minn, A.J. et al. (2005) Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J. Clin. Invest., 115, 44-55.
    • (2005) J. Clin. Invest , vol.115 , pp. 44-55
    • Minn, A.J.1
  • 48
    • 34147211281 scopus 로고    scopus 로고
    • Lung metastasis genes couple breast tumor size and metastatic spread
    • Minn, A.J. et al. (2007) Lung metastasis genes couple breast tumor size and metastatic spread. Proc. Natl Acad. Sci. USA, 104, 6740-6745.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6740-6745
    • Minn, A.J.1
  • 49
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos, P.D. et al. (2009) Genes that mediate breast cancer metastasis to the brain. Nature, 459, 1005-1009.
    • (2009) Nature , vol.459 , pp. 1005-1009
    • Bos, P.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.