SCOPUS 정보 검색 플랫폼

Volumn 9, Issue 8, 2014, Pages 1638-1654

The discovery and development of the N-substituted trans-3,4-dimethyl-4-(3- hydroxyphenyl)piperidine class of pure opioid receptor antagonists

(2) Carroll, F Ivy a Dolle, Roland E b

a RTI INTERNATIONAL (United States)

b CUBIST PHARMACEUTICALS INC (United States)

Author keywords

alvimopan; drug design; JDTic; medicinal chemistry; opioid antagonists

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ALVIMOPAN; KAPPA OPIATE RECEPTOR ANTAGONIST; LY 255582; NALTREXONE; OPIATE ANTAGONIST; UNCLASSIFIED DRUG; NARCOTIC ANTAGONIST; OPIATE RECEPTOR; PIPERIDINE DERIVATIVE; PROTEIN BINDING;

ANASTOMOSIS; ANXIETY; BINDING AFFINITY; CRYSTAL STRUCTURE; DEPRESSION; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG DESIGN; DRUG DOSE; DRUG SCREENING; DRUG SYNTHESIS; GASTROINTESTINAL TRACT FUNCTION; HUMAN; INTESTINE FUNCTION; INTESTINE RESECTION; NONHUMAN; OBESITY; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; STRUCTURE ACTIVITY RELATION; SUBSTANCE ABUSE; UPPER GASTROINTESTINAL TRACT; X RAY CRYSTALLOGRAPHY; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HUMANS; NARCOTIC ANTAGONISTS; PIPERIDINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905259899 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201402142 Document Type: Review

Times cited : (19)

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