Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2- a]pyrazine as μ-opioid receptor antagonists

Journal of Medicinal Chemistry

Volumn 49, Issue 25, 2006, Pages 7290-7306

  Le Bourdonnec, Bertrand ^a   Goodman, Allan J ^a   Graczyk, Thomas M ^a   Belanger, Serge ^a   Seida, Pamela R ^a   Dehaven, Robert N ^a   Dolle, Roland E ^a  

^a ADOLOR CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [7,8 DIMETHYL 2 (2 CHLOROBENZYL)OCTAHYDRO 1H PYRIDO[1,2 A]PYRAZIN 8 YL]PHENOL; 3,4 DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; NALTREXONE; OCTAHYDRO 1H PYRIDO[1,2 A]PYRAZINE; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; QUINOLIZIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIGANDS; MOLECULAR STRUCTURE; PYRAZINES; PYRIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845472620     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0604878     Document Type: Article

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