Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of μ-opioid receptor antagonists

Journal of Medicinal Chemistry

Volumn 49, Issue 25, 2006, Pages 7278-7289

  Le Bourdonnec, Bertrand ^a   Goodman, Allan J ^a   Michaut, Mathieu ^a   Ye, Hai Fen ^a   Graczyk, Thomas M ^a   Belanger, Serge ^a   Herbertz, Torsten ^a   Yap, Glenn P A ^b   DeHaven, Robert N ^a   Dolle, Roland E ^a  

^a ADOLOR CORPORATION   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1,2 DIMETHYL 7 PHENYLOCTAHYDRO 1H QUINOLIZIN 2 YL)PHENOL; 3 (2,3 DIMETHYL 7 PHENYLOCTAHYDRO 1H QUINOLIZIN 2 YL)PHENOL; ETHYLENE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; N PHENETHYL 3,4 DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE; NALOXONE; NALTREXONE; PHENYL GROUP; PIPERIDINE DERIVATIVE; QUINOLIZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IN VITRO STUDY; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845477636     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060486f     Document Type: Article

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