Investigation of the N-substituent conformation governing potency and μ receptor subtype-selectivity in (+)-(3R,4R)-dimethyl-4-(3- hydroxyphenyl)piperidine opioid antagonists

Journal of Medicinal Chemistry

Volumn 41, Issue 11, 1998, Pages 1980-1990

  Thomas, James B ^a   Wayne Mascarella, S ^a   Rothman, Richard B ^b   Partilla, John S ^b   Xu, Heng ^a,b   McCullough, Karen B ^b   Dersch, Christina M ^b   Cantrell, Buddy E ^c   Zimmerman, Dennis M ^c   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

^b NIDA Addiction Research Center   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONAL GROUP; N (4 PHENYL 2 BUTENYL)DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE FUMARATE; N [(2 CHLOROPHENYL) 2 BUTENYL]DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE FUMARATE; OPIATE ANTAGONIST; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BRAIN; CRYSTALLOGRAPHY, X-RAY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; MOLECULAR CONFORMATION; NARCOTIC ANTAGONISTS; PIPERIDINES; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 15444345625     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980063g     Document Type: Article

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