Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells

Journal of the American Chemical Society

Volumn 136, Issue 30, 2014, Pages 10777-10782

  Kambe, Tohru ^a   Correia, Bruno E ^a   Niphakis, Micah J ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONDENSATION REACTIONS; CYTOLOGY; MASS SPECTROMETRY; MOLECULES; PROBES; PROTEINS;

BIOCHEMICAL PATHWAY; BIOLOGICAL PROCESS; PHENOTYPIC SCREENING; PROTEIN INTERACTION; SCAFFOLDING PROTEINS; STRUCTURAL DIVERSITY; STRUCTURE ACTIVITY RELATIONSHIPS; TARGET IDENTIFICATION;

SCAFFOLDS (BIOLOGY);

ALKYNE; AZIDE; AZIRINE DERIVATIVE; ENZYME; PROTEASOME; PROTEOME; RIBOSOME PROTEIN; SCAFFOLD PROTEIN; DIAZOMETHANE; MOLECULAR LIBRARY; MOLECULAR PROBE; PROTEIN;

ARTICLE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR LIBRARY; PEPTIDE MAPPING; PHENOTYPE; POLYMERIZATION; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN TARGETING; SYNTHESIS; CELL LINE; CHEMISTRY; METABOLISM; MOLECULAR PROBE; PROCEDURES; PROTEIN ANALYSIS;

ALKYNES; CELL LINE; DIAZOMETHANE; HUMANS; MOLECULAR PROBES; PROTEIN INTERACTION MAPPING; PROTEINS; PROTEOME; SMALL MOLECULE LIBRARIES;

EID: 84905233588     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja505517t     Document Type: Article

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