Down-regulation of the P-glycoprotein relevant for multidrug resistance by intracellular acidification through the crosstalk of MAPK signaling pathways

International Journal of Biochemistry and Cell Biology

Volumn 54, Issue , 2014, Pages 111-121

  Jin, Weina ^a,b   Lu, Ying ^a,c   Li, Qinghua ^a   Wang, Jian ^a   Zhang, Hongju ^a   Chang, Guoqiang ^a   Lin, Yani ^a   Pang, Tianxiang ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

Intracellular acidification; Intracellular pH; Mitogen activated protein kinase; Multidrug resistance; P glycoprotein

Indexed keywords

CARIPORIDE; CYCLOHEXIMIDE; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN; STRESS ACTIVATED PROTEIN KINASE; ACID; ANTINEOPLASTIC ANTIBIOTIC; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; MULTIDRUG RESISTANCE PROTEIN 1; SMALL INTERFERING RNA;

ACIDIFICATION; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HL 60 CELL LINE; HUMAN; HUMAN CELL; K562 CELL LINE; LEUKEMIA CELL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN STABILITY; PROTEIN SYNTHESIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL FUNCTION; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; METABOLISM; MULTIDRUG RESISTANCE; PH; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE SILENCING; PH MEASUREMENT;

ACIDS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; CELL PHYSIOLOGICAL PHENOMENA; CELL PROLIFERATION; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HL-60 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; P-GLYCOPROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84905196280     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.06.016     Document Type: Article

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