The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes

FEBS Journal

Volumn 281, Issue 15, 2014, Pages 3433-3445

  Zhu, Jing ^a   Yan, Jenny ^a,b   Thornhill, William B ^a  

^a FORDHAM UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

astrocyte; endoplasmic reticulum; Golgi; potassium channel; subcellular localization

Indexed keywords

BREFELDIN A; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.6;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DEATH; CELL DENSITY; CELL MIGRATION; CELL STRUCTURE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HALF LIFE TIME; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TRANSPORT; RAT; SIALYLATION;

ASTROCYTE; ENDOPLASMIC RETICULUM; GOLGI; POTASSIUM CHANNEL; SUBCELLULAR LOCALIZATION;

ANIMALS; ASTROCYTES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; GLYCOSYLATION; GOLGI APPARATUS; HUMANS; INTRACELLULAR MEMBRANES; KV1.3 POTASSIUM CHANNEL; KV1.6 POTASSIUM CHANNEL; MCF-7 CELLS; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEIN TRANSPORT; RATS;

EID: 84905182946     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12871     Document Type: Article

References (35)

1. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, et al,. (2003) International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev 55, 583-586.
2. Vacher H, Mohapatra DP, &, Trimmer JS, (2008) Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev 88, 1407-1447.
3. Verkhratsky A, &, Steinhäuser C, (2000) Ion channels in glial cells. Brain Res Rev 32, 380-412.
4. Hille B, (1992) Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA.
5. Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, &, Herculano-Houzel S, (2009) Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol 513, 532-541.
6. Herculano-Houzel S, &, Lent R, (2005) Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J Neurosci 25, 2518-2521.
7. Nedergaard M, Ransom B, &, Goldman SA, (2003) New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 26, 523-530.
8. Giaume C, Kirchhoff F, Matute C, Reichenbach A, &, Verkhratsky A, (2007) Glia: the fulcrum of brain diseases. Cell Death Differ 14, 1324-1335.
9. Fellin T, &, Carmignoto G, (2004) Neurone-to-astrocyte signalling in the brain represents a distinct multifunctional unit. J Physiol 559, 3-15.
10. Giaume C, Koulakoff A, Roux L, Holcman D, &, Rouach N, (2010) Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat Rev Neurosci 11, 87-99.
11. Smart SL, Bosma MM, &, Tempel BL, (1997) Identification of the delayed rectifier potassium channel, Kv1.6, in cultured astrocytes. Glia 20, 127-134.
12. Roy ML, Saal D, Perney T, Sontheimer H, Waxman SG, &, Kaczmarek LK, (1996) Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides. Glia 18, 177-184.
13. MacFarlane SN, &, Sontheimer H, (2000) Modulation of Kv1.5 currents by Src tyrosine phosphorylation: potential role in the differentiation of astrocytes. J Neurosci 20, 5245-5253.
14. Preussat K, Beetz C, Schrey M, Kraft R, Wölfl S, Kalff R, &, Patt S, (2003) Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. Neurosci Lett 346, 33-36.
15. Wang SY, Castle NA, &, Wang GK, (1992) Identification of RBK1 potassium channels in C6 astrocytoma cells. Glia 5, 146-153.
16. Akhtar S, McIntosh P, Bryan-Sisneros A, Barratt L, Robertson B, &, Dolly JO, (1999) A functional spliced-variant of beta 2 subunit of Kv1 channels in C6 glioma cells and reactive astrocytes from rat lesioned cerebellum. Biochemistry 38, 16984-16992.
17. Nebenführ A, Ritzenthaler C, &, Robinson DG, (2002) Brefeldin A: deciphering an enigmatic inhibitor of secretion. Plant Physiol 130, 1102-1108.
18. Seemann J, Jokitalo E, Pypaert M, &, Warren G, (2000) Matrix proteins can generate the higher order architecture of the Golgi apparatus. Nature 407, 1022-1026.
19. Zhu J, Yan J, &, Thornhill WB, (2012) N-glycosylation promotes the cell surface expression of Kv1.3 potassium channels. FEBS J 279, 2632-2644.
20. Chege NW, &, Pfeffer SR, (1990) Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network. J Cell Biol 111, 893-899.
21. Johnston PA, Stieber A, &, Gonatas NK, (1994) A hypothesis on the traffic of MG160, a medial Golgi sialoglycoprotein, from the trans-Golgi network to the Golgi cisternae. J Cell Sci 107, 529-537.
22. Larsson O, Carlberg M, &, Zetterberg A, (1993) Selective killing induced by an inhibitor of N-linked glycosylation. J Cell Sci 106, 299-307.
23. Duque A, Gazula VR, &, Kaczmarek LK, (2013) Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Dev Neurobiol 73, 841-855.
24. Doczi MA, Morielli AD, &, Damon DH, (2008) Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation. Am J Physiol Regul Integr Comp Physiol 295, R733-R740.
25. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, et al,. (2006) Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci USA 103, 17414-17419.
26. Banfield DK, (2011) Mechanisms of protein retention in the Golgi. Cold Spring Harb Perspect Biol 3, a005264.
27. Nilsson T, Slusarewicz P, Hoe MH, &, Warren G, (1993) Kin recognition. A model for the retention of Golgi enzymes. FEBS Lett 330, 1-4.
28. Linstedt AD, Mehta A, Suhan J, Reggio H, &, Hauri H, (1997) Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. Mol Biol Cell 8, 1073-1087.
29. Lai HC, &, Jan LY, (2006) The distribution and targeting of neuronal voltage-gated ion channels. Nat Rev Neurosci 7, 548-562.
30. Szabò I, Bock J, Jekle A, Soddemann M, Adams C, Lang F, Zoratti M, &, Gulbins E, (2005) A novel potassium channel in lymphocyte mitochondria. J Biol Chem 280, 12790-12798.
31. Szabõ I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, Zoratti M, &, Gulbins E, (2008) Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci USA 105, 14861-14866.
32. Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, &, Szabò I, (2012) Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med 4, 577-593.
33. Banerjee D, Das S, Molina SA, Madgwick D, Katz MR, Jena S, Bossmann LK, Pal D, &, Takemoto DJ, (2011) Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43. J Biol Chem 286, 24519-24533.
34. + channels. Ann N Y Acad Sci 868, 233-285.
35. + channel alpha- and beta-subunit polypeptides. Neuropharmacology 35, 851-865.